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Article(id=1321425657280713403, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425656810951355, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.10.006, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1756310400000, acceptedDateStr=2025-08-28, onlineDate=1792982027597, onlineDateStr=2026-10-26, pubDate=1780070400000, pubDateStr=2026-05-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982027597, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982027597, creator=13701087609, updateTime=1792982027597, updator=13701087609, issue=Issue{id=1321425656810951355, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='10', pageStart='1009', pageEnd='1120', issueExtLink='null', onlineDate='null', pubDate='1780070400000', pubDateStr='2026-05-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982027485, creator='13701087609', updateTime=1792983064574, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321430006727820106, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425656810951355, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321430006727820107, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425656810951355, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1046, endPage=1056, ext={EN=ArticleExt(id=1321425657448485564, articleId=1321425657280713403, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Study on identification of key quality control indicators of Crataegi Fructus slices based on “appearance characteristics-chemical composition” correlation model, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective:

To construct the correlation model of "appearance characteristics-chemical components" of Crataegi Fructus by integrating appearance characteristics (diameter, thickness and total mass) and internal quality indicators (water content, extract, total ash and HPLC characteristic spectrum) to identify the key quality control indicators of Crataegi Fructus.

Methods:

After measuring the indicators, principal component analysis (PCA), orthogonal partial least squares discriminant analysis (OPLS-DA), factor analysis (FA) and IQR variability analysis were used for data mining, and key indicators were determined by cross-validation of multiple methods.

Results:

PCA and OPLS-DA identified seven indicators, including water content, chlorogenic acid, cryptochlorogenic acid, et al. FA extracted cryptochlorogenic acid, hyperoside, and isoquercitrin. IQR analysis yielded 11 variability indicators. Overall, cryptochlorogenic acid and hyperoside were identified as core indicators across all three analytical methods.

Conclusion:

The correlation model of "appearance characteristics-chemical composition" of Crataegi Fructus was established, and the key quality control indexes were determined as cryptochlorogenic acid and hyperoside, which provided a new research method for the standardization of quality of Chinese herbal slices.

, authors=Fang LÜ1, Meng-yu SUN1, Wei LIU1, Jia-mu MA1, Chang-qi ZHAI2, 3, 4, Xiao-dan QI2, 3, 4, Feng ZHANG1, Ming-xia LI1, Le-tian YING1, Gai-mei SHE1, *, authorsList=Fang LÜ, Meng-yu SUN, Wei LIU, Jia-mu MA, Chang-qi ZHAI, Xiao-dan QI, Feng ZHANG, Ming-xia LI, Le-tian YING, Gai-mei SHE, authorCompany=null, correspAuthors=Gai-mei SHE, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425657687560893, articleId=1321425657280713403, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=基于“外观性状-化学成分”关联模型的山楂饮片质量控制关键指标辨识研究, columnId=1236330556003242277, journalTitle=中国新药杂志, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的：

基于19批山楂样品（SZ1~SZ19），通过整合外观性状（直径、厚度、总质量）与内在质量指标（水分、浸出物、总灰分、HPLC特征图谱），构建“外观性状-化学成分”关联模型，辨识山楂质量控制关键指标。

方法：

测定各项指标后，采用主成分分析（PCA）、正交偏最小二乘判别分析（OPLS-DA）、因子分析（FA）和IQR变异性分析进行数据挖掘，通过多方法结果交叉验证确定关键指标。

结果：

PCA分析和OPLS-DA分析筛选出水分、绿原酸、隐绿原酸等7个指标；FA提取出隐绿原酸、金丝桃苷和异槲皮苷；IQR分析获得11个变异性指标。综合发现隐绿原酸和金丝桃苷在3种分析方法中均被识别为核心指标。

结论：

建立山楂“外观性状-化学成分”关联模型，确定隐绿原酸和金丝桃苷为关键质量控制指标，为中药饮片质量标准化提供了新的研究方法。

, authors=吕芳1, 孙梦豫1, 刘薇1, 马嘉慕1, 翟昌琪2, 3, 4, 齐晓丹2, 3, 4, 张凤1, 黎明霞1, 应乐天1, 折改梅1, *, authorsList=吕芳, 孙梦豫, 刘薇, 马嘉慕, 翟昌琪, 齐晓丹, 张凤, 黎明霞, 应乐天, 折改梅, authorCompany=null, correspAuthors=折改梅, authorNote=

吕芳，女，硕士，主要从事中药化学成分研究。E-mail: 。

孙梦豫，女，硕士，主要从事中药化学成分研究。E-mail: 。

, correspAuthorsNote=
* 折改梅，女，博士，研究员，主要从事中（民族）药药效物质和新药创制研究。E-mail: 。
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孙梦豫，女，硕士，主要从事中药化学成分研究。E-mail: 。

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3Shandong Technology Innovation Center of Gelatin-based Traditional Chinese Medicine, Liaocheng 252200, China
4National Engineering Technology Research Center for Gelatin-based Traditional Chinese Medicine, Shandong Key Laboratory of Gelatine TCM Research and Development, Dong'e Ejiao Co., Ltd., Liaocheng 252200, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425661063975652, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425657280713403, authorId=1321425660900397791, language=CN, stringName=翟昌琪, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, 3, 4, address=2东阿阿胶股份有限公司，聊城 252200
3山东省胶类中药技术创新中心，聊城 252200
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3Shandong Technology Innovation Center of Gelatin-based Traditional Chinese Medicine, Liaocheng 252200, China
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基于“外观性状-化学成分”关联模型的山楂饮片质量控制关键指标辨识研究
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吕芳 1 , 孙梦豫 1 , 刘薇 1 , 马嘉慕 1 , 翟昌琪 2, 3, 4 , 齐晓丹 2, 3, 4 , 张凤 1 , 黎明霞 1 , 应乐天 1 , 折改梅 1, *
中国新药杂志 | 实验研究 2026,35(10): 1046-1056
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中国新药杂志 |实验研究 2026 , 35 (10) : 1046 -1056
基于“外观性状-化学成分”关联模型的山楂饮片质量控制关键指标辨识研究
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吕芳1 , 孙梦豫1 , 刘薇1, 马嘉慕1, 翟昌琪2, 3, 4, 齐晓丹2, 3, 4, 张凤1, 黎明霞1, 应乐天1, 折改梅1, *
作者信息
  • 1北京中医药大学中药学院，北京 100029
  • 2东阿阿胶股份有限公司，聊城 252200
  • 3山东省胶类中药技术创新中心，聊城 252200
  • 4东阿阿胶股份有限公司山东省胶类中药研究与开发重点实验室国家胶类中药工程技术研究中心，聊城 252200
通讯作者:
* 折改梅，女，博士，研究员，主要从事中（民族）药药效物质和新药创制研究。E-mail: 。
作者简介:

吕芳，女，硕士，主要从事中药化学成分研究。E-mail: 。

孙梦豫，女，硕士，主要从事中药化学成分研究。E-mail: 。

Study on identification of key quality control indicators of Crataegi Fructus slices based on “appearance characteristics-chemical composition” correlation model
Fang LÜ1 , Meng-yu SUN1 , Wei LIU1, Jia-mu MA1, Chang-qi ZHAI2, 3, 4, Xiao-dan QI2, 3, 4, Feng ZHANG1, Ming-xia LI1, Le-tian YING1, Gai-mei SHE1, *
Affiliations
  • 1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China
  • 2Dong'e Ejiao Co., Ltd., Liaocheng 252200, China
  • 3Shandong Technology Innovation Center of Gelatin-based Traditional Chinese Medicine, Liaocheng 252200, China
  • 4National Engineering Technology Research Center for Gelatin-based Traditional Chinese Medicine, Shandong Key Laboratory of Gelatine TCM Research and Development, Dong'e Ejiao Co., Ltd., Liaocheng 252200, China
出版时间: 2026-05-30 doi: 10.20251/j.cnki.1003-3734.2026.10.006
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摘要
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目的：

基于19批山楂样品（SZ1~SZ19），通过整合外观性状（直径、厚度、总质量）与内在质量指标（水分、浸出物、总灰分、HPLC特征图谱），构建“外观性状-化学成分”关联模型，辨识山楂质量控制关键指标。

方法：

测定各项指标后，采用主成分分析（PCA）、正交偏最小二乘判别分析（OPLS-DA）、因子分析（FA）和IQR变异性分析进行数据挖掘，通过多方法结果交叉验证确定关键指标。

结果：

PCA分析和OPLS-DA分析筛选出水分、绿原酸、隐绿原酸等7个指标；FA提取出隐绿原酸、金丝桃苷和异槲皮苷；IQR分析获得11个变异性指标。综合发现隐绿原酸和金丝桃苷在3种分析方法中均被识别为核心指标。

结论：

建立山楂“外观性状-化学成分”关联模型，确定隐绿原酸和金丝桃苷为关键质量控制指标，为中药饮片质量标准化提供了新的研究方法。

山楂  /  关键指标  /  质量评价
Objective:

To construct the correlation model of "appearance characteristics-chemical components" of Crataegi Fructus by integrating appearance characteristics (diameter, thickness and total mass) and internal quality indicators (water content, extract, total ash and HPLC characteristic spectrum) to identify the key quality control indicators of Crataegi Fructus.

Methods:

After measuring the indicators, principal component analysis (PCA), orthogonal partial least squares discriminant analysis (OPLS-DA), factor analysis (FA) and IQR variability analysis were used for data mining, and key indicators were determined by cross-validation of multiple methods.

Results:

PCA and OPLS-DA identified seven indicators, including water content, chlorogenic acid, cryptochlorogenic acid, et al. FA extracted cryptochlorogenic acid, hyperoside, and isoquercitrin. IQR analysis yielded 11 variability indicators. Overall, cryptochlorogenic acid and hyperoside were identified as core indicators across all three analytical methods.

Conclusion:

The correlation model of "appearance characteristics-chemical composition" of Crataegi Fructus was established, and the key quality control indexes were determined as cryptochlorogenic acid and hyperoside, which provided a new research method for the standardization of quality of Chinese herbal slices.

Crataegi Fructus  /  key indicators  /  quality evaluation
吕芳, 孙梦豫, 刘薇, 马嘉慕, 翟昌琪, 齐晓丹, 张凤, 黎明霞, 应乐天, 折改梅. 基于“外观性状-化学成分”关联模型的山楂饮片质量控制关键指标辨识研究. 中国新药杂志, 2026 , 35 (10) : 1046 -1056 . DOI: 10.20251/j.cnki.1003-3734.2026.10.006
Fang LÜ, Meng-yu SUN, Wei LIU, Jia-mu MA, Chang-qi ZHAI, Xiao-dan QI, Feng ZHANG, Ming-xia LI, Le-tian YING, Gai-mei SHE. Study on identification of key quality control indicators of Crataegi Fructus slices based on “appearance characteristics-chemical composition” correlation model[J]. Chinese Journal of New Drugs, 2026 , 35 (10) : 1046 -1056 . DOI: 10.20251/j.cnki.1003-3734.2026.10.006
基金
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  • 中央引导地方科技发展资金资助项目(YDZX2023090)
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doi: 10.20251/j.cnki.1003-3734.2026.10.006
  • 首发时间：2026-10-26
  • 出版时间：2026-05-30
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  • 录用日期：2025-08-28
基金
中央引导地方科技发展资金资助项目(YDZX2023090)
作者信息
    1北京中医药大学中药学院，北京 100029
    2东阿阿胶股份有限公司，聊城 252200
    3山东省胶类中药技术创新中心，聊城 252200
    4东阿阿胶股份有限公司山东省胶类中药研究与开发重点实验室国家胶类中药工程技术研究中心，聊城 252200

通讯作者:

* 折改梅，女，博士，研究员，主要从事中（民族）药药效物质和新药创制研究。E-mail: 。
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https://castjournals.cast.org.cn/joweb/zgxyzz/CN/10.20251/j.cnki.1003-3734.2026.10.006
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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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