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Patient-derived explants (PDEs) still lack a unified definition. Based on a comprehensive review of multiple studies, they are defined herein as "thin slices of tissue obtained from living tissues using tissue slicing techniques that retain cellular activity, intact tissue composition, and cellular distribution characteristics”. PDEs have been in existence for many years, but they have not yet been widely used in new drug research or clinical translational studies. Efforts to improve the culture system of PDEs and integrate more analytical techniques with the PDEs have enabled the detection of more markers using fewer tissues. As an undeconstructed ex vivo model, PDEs preserve the original tissue cell types, cellular distribution, and cellular activity and feature a high establishment rate and a short detection cycle, making them suitable for drug sensitivity testing and mechanism-related studies. In particular, they show great potential in tumour-related drug sensitivity assays and immunological studies. Therefore, PDEs represent powerful ex vivo models for disease research and new drug development.

, authors=Zi-tong LIU, Min-yu LIU^*, authorsList=Zi-tong LIU, Min-yu LIU, authorCompany=null, correspAuthors=Min-yu LIU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425656555094269, articleId=1321425656156635387, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=患者来源的外植体应用于疾病研究和新药研发研究, columnId=1236330553964810454, journalTitle=中国新药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

目前，患者来源的外植体（patient-derived explants, PDEs）仍缺乏统一的定义，综合多方研究，本文将其定义为“通过使用活组织切片技术从活组织中获得的保留了细胞活性、完整的组织成分和细胞分布特征的组织薄片”。PDEs技术已存在多年，但仍未在新药研究及临床转化研究中广泛应用；为了改善PDEs的培养体系，并将更多的分析技术与PDEs体系相结合，使其能够在较少组织条件下实现更多标志物的检测。PDEs作为一种未经解构的离体模型，可以保留原始组织细胞类型、细胞分布和细胞活性，且建成率高、检测周期短，适用于药敏测试和机制相关研究，特别是在肿瘤相关的药敏检测和免疫研究方面具有巨大潜力。因此，PDEs是疾病研究和新药研发的强大离体模型。

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刘姿彤，女，硕士研究生，主要从事代谢相关疾病的新药研究。E-mail: L1198946870@163.com。

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刘姿彤，女，硕士研究生，主要从事代谢相关疾病的新药研究。E-mail: L1198946870@163.com。

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