Article(id=1321425634178482275, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425597998420385, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.08.012, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1769961600000, acceptedDateStr=2026-02-02, onlineDate=1792982022089, onlineDateStr=2026-10-26, pubDate=1777478400000, pubDateStr=2026-04-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982022089, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982022089, creator=13701087609, updateTime=1792982022089, updator=13701087609, issue=Issue{id=1321425597998420385, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='8', pageStart='785', pageEnd='896', issueExtLink='null', onlineDate='null', pubDate='1777478400000', pubDateStr='2026-04-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982013463, creator='13701087609', updateTime=1792983113439, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321430211678290797, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425597998420385, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321430211678290798, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425597998420385, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=875, endPage=881, ext={EN=ArticleExt(id=1321425634396586084, articleId=1321425634178482275, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Memory T cells biodistribution in NCG mice, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To systematically investigate the dynamic tissue distribution and tumor-targeting characteristics of memory T cells in non-tumor-bearing and tumor-bearing NCG mouse models using validated qPCR and in vivo imaging techniques.
Methods: A total of 144 NCG mice were randomly divided into non-tumor-bearing control, tumor-bearing control, non-tumor-bearing treatment, and tumor-bearing treatment groups. The treatment groups received a single intravenous injection of 1×107 memory T cells per mouse, while the control groups received vehicle only. In vivo imaging was performed on days 1, 3, 7, 14, 21, and 28 post-administration. Tissues and body fluids were collected at the same time points, and the genomic distribution of memory T cells was quantified by qPCR.
Results: In non-tumor-bearing mice, memory T cells were initially (day 1~3) distributed mainly in highly perfused organs such as the lung, spleen, and liver, followed by a rapid decline and near clearance by day 14. In tumor-bearing mice, the early distribution pattern resembled that in non-tumor-bearing animals; however, starting from day 14 onward, significant tumor enrichment was observed and persisted until day 28, accompanied by a concurrent decrease in cell concentrations in non-target tissues.
Conclusion: Memory T cells demonstrate a trend of rapid clearance in the absence of antigenic stimulation, whereas in the presence of tumor, they exhibit antigen-driven tumor homing and long-term persistence capabilities.
, authors=Xiao-jin QIN
1, 2, Cai-ling DAI
2, Yu-ying WEN
2, Jian-min GUO
2, Xiao-qun DUAN
1, *, Wei YANG
1, 2, *, authorsList=Xiao-jin QIN, Cai-ling DAI, Yu-ying WEN, Jian-min GUO, Xiao-qun DUAN, Wei YANG, authorCompany=null, correspAuthors=Xiao-qun DUAN, Wei YANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425634983788645, articleId=1321425634178482275, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=记忆T细胞在NCG小鼠体内的生物分布研究, columnId=1236330556003242277, journalTitle=中国新药杂志, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的： 利用经方法学验证的qPCR技术及活体成像技术，系统研究记忆T细胞在非移植瘤与移植瘤NCG小鼠模型中的动态组织分布及其肿瘤靶向特性。
方法： 取144只NCG小鼠，随机分为移植瘤与非移植瘤阴性对照组及记忆T细胞注射液组，给药组给予记忆T细胞1×107 cells·只-1，阴性对照组不给药。于给药后1、3、7、14、21及28 d进行活体成像，并于各时间点采集各组织或体液，通过qPCR定量分析记忆T细胞基因组分布。
结果： 非移植瘤小鼠中，记忆T细胞早期（1~3 d）主要分布于肺脏、脾脏、肝脏等高血流灌注器官，随后逐渐减少，d 14基本清除。移植瘤组早期分布与非移植瘤组相似，d 14后出现的显著肿瘤富集持续至d 28，非靶组织细胞浓度同步下降。
结论： 记忆T细胞在无抗原刺激下呈快速清除趋势，而在肿瘤存在时则表现出抗原驱动性肿瘤归巢与长期驻留能力。
, authors=秦筱津
1, 2, 代彩玲
2, 温玉莹
2, 郭健敏
2, 段小群
1, *, 杨威
1, 2, *, authorsList=秦筱津, 代彩玲, 温玉莹, 郭健敏, 段小群, 杨威, authorCompany=null, correspAuthors=段小群, 杨威, authorNote=
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1, 2, address=
1School of Pharmacy, Guilin Medical University, Guilin 541199, China
2Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-clinical Evaluation and Research, Non-clinical Evaluation Sub-center for Traditional Chinese Medicine of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Conghua District Anti-infective Drug Research and Evaluation Engineering and Technology Research Center, Guangzhou 510990, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425637131272305, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425634178482275, authorId=1321425636942528621, language=CN, stringName=秦筱津, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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1桂林医科大学药学院，桂林 541199
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秦筱津，女，硕士研究生，主要从事细胞药物研究。E-mail: 1608830324@qq.com。
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秦筱津，女，硕士研究生，主要从事细胞药物研究。E-mail: 1608830324@qq.com。
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2Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-clinical Evaluation and Research, Non-clinical Evaluation Sub-center for Traditional Chinese Medicine of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Conghua District Anti-infective Drug Research and Evaluation Engineering and Technology Research Center, Guangzhou 510990, China), AuthorCompanyExt(id=1321425636867031147, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425634178482275, companyId=1321425636846059625, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2广州湾区生物医药研究院/广东莱恩医药研究院有限公司/广东省药物非临床评价与研究重点实验室/国家中药现代化工程技术研究中心中药非临床评价分中心/广东省创新药物评价与研究工程技术研究中心/从化区抗感染药物研究与评价工程技术研究中心，广州 510990)])]), Author(id=1321425637219352691, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425634178482275, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425637299044469, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425634178482275, authorId=1321425637219352691, language=EN, stringName=Cai-ling DAI, firstName=Cai-ling, middleName=null, lastName=DAI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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2Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-clinical Evaluation and Research, Non-clinical Evaluation Sub-center for Traditional Chinese Medicine of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Conghua District Anti-infective Drug Research and Evaluation Engineering and Technology Research Center, Guangzhou 510990, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425637378736246, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425634178482275, authorId=1321425637219352691, language=CN, stringName=代彩玲, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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2广州湾区生物医药研究院/广东莱恩医药研究院有限公司/广东省药物非临床评价与研究重点实验室/国家中药现代化工程技术研究中心中药非临床评价分中心/广东省创新药物评价与研究工程技术研究中心/从化区抗感染药物研究与评价工程技术研究中心，广州 510990, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425636846059625, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425634178482275, xref=2, ext=[AuthorCompanyExt(id=1321425636854448234, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425634178482275, companyId=1321425636846059625, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-clinical Evaluation and Research, Non-clinical Evaluation Sub-center for Traditional Chinese Medicine of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Conghua District Anti-infective Drug Research and Evaluation Engineering and Technology Research Center, Guangzhou 510990, China), AuthorCompanyExt(id=1321425636867031147, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425634178482275, companyId=1321425636846059625, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2广州湾区生物医药研究院/广东莱恩医药研究院有限公司/广东省药物非临床评价与研究重点实验室/国家中药现代化工程技术研究中心中药非临床评价分中心/广东省创新药物评价与研究工程技术研究中心/从化区抗感染药物研究与评价工程技术研究中心，广州 510990)])]), Author(id=1321425637450039416, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425634178482275, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425637563285626, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425634178482275, authorId=1321425637450039416, language=EN, stringName=Yu-ying WEN, firstName=Yu-ying, middleName=null, lastName=WEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
2, address=
2Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-clinical Evaluation and Research, Non-clinical Evaluation Sub-center for Traditional Chinese Medicine of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Conghua District Anti-infective Drug Research and Evaluation Engineering and Technology Research Center, Guangzhou 510990, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425637638783099, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425634178482275, authorId=1321425637450039416, language=CN, stringName=温玉莹, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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2广州湾区生物医药研究院/广东莱恩医药研究院有限公司/广东省药物非临床评价与研究重点实验室/国家中药现代化工程技术研究中心中药非临床评价分中心/广东省创新药物评价与研究工程技术研究中心/从化区抗感染药物研究与评价工程技术研究中心，广州 510990, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425636846059625, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425634178482275, xref=2, ext=[AuthorCompanyExt(id=1321425636854448234, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425634178482275, companyId=1321425636846059625, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-clinical Evaluation and Research, Non-clinical Evaluation Sub-center for Traditional Chinese Medicine of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Conghua District Anti-infective Drug Research and Evaluation Engineering and Technology Research Center, Guangzhou 510990, China), AuthorCompanyExt(id=1321425636867031147, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425634178482275, companyId=1321425636846059625, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2广州湾区生物医药研究院/广东莱恩医药研究院有限公司/广东省药物非临床评价与研究重点实验室/国家中药现代化工程技术研究中心中药非临床评价分中心/广东省创新药物评价与研究工程技术研究中心/从化区抗感染药物研究与评价工程技术研究中心，广州 510990)])]), Author(id=1321425637714280573, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425634178482275, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425637802360959, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425634178482275, authorId=1321425637714280573, language=EN, stringName=Jian-min GUO, firstName=Jian-min, middleName=null, lastName=GUO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
2, address=
2Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-clinical Evaluation and Research, Non-clinical Evaluation Sub-center for Traditional Chinese Medicine of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Conghua District Anti-infective Drug Research and Evaluation Engineering and Technology Research Center, Guangzhou 510990, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425637865275520, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425634178482275, authorId=1321425637714280573, language=CN, stringName=郭健敏, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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