Article(id=1321425633058607722, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425625915707977, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.09.008, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1750089600000, acceptedDateStr=2025-06-17, onlineDate=1792982021821, onlineDateStr=2026-10-26, pubDate=1778774400000, pubDateStr=2026-05-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982021821, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982021821, creator=13701087609, updateTime=1792982021821, updator=13701087609, issue=Issue{id=1321425625915707977, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='9', pageStart='897', pageEnd='1008', issueExtLink='null', onlineDate='null', pubDate='1778774400000', pubDateStr='2026-05-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982020119, creator='13701087609', updateTime=1792983090252, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321430114441745406, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425625915707977, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321430114441745407, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425625915707977, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=951, endPage=959, ext={EN=ArticleExt(id=1321425633238962795, articleId=1321425633058607722, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Novel gamma-aminobutyric acid type A receptor modulators brexanolone and zuranolone: advances in postpartum depression treatment, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

The rapid and sustained antidepressant effects of brexanolone and zuranolone represent a breakthrough in the treatment of postpartum depression (PPD) fueling in-depth research into the antidepressant mechanisms of gamma-aminobutyric acid type A receptor (GABAAR) modulators. This article systematically reviews 14 clinical trials, and evaluates the clinical advantages and potential limitations of brexanolone and zuranolone though post-hoc analysis, providing valuable insights for clinical application. Additionally, based on recent mechanistic studies of brexanolone and its analogs, three hypotheses are proposed to explain their rapid and lasting antidepressant effects: the neuroendocrine hypothesis, neural oscillation hypothesis, and neurotrophic factor hypothesis, offering novel directions for development of drugs for PPD.

, authors=Ya-ting DENG¹, Yue-chi DAI¹, Yan ZHAO¹, Jun CHANG², Yan-yan CHE¹, Zi-yun DUAN^{3, *}, authorsList=Ya-ting DENG, Yue-chi DAI, Yan ZHAO, Jun CHANG, Yan-yan CHE, Zi-yun DUAN, authorCompany=null, correspAuthors=Zi-yun DUAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425633457066604, articleId=1321425633058607722, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=新型γ-氨基丁酸A型受体调节剂布瑞诺龙与舒拉诺龙的产后抑郁症治疗新进展, columnId=1236330553964810454, journalTitle=中国新药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

布瑞诺龙和舒拉诺龙的快速、持久抗抑郁疗效为产后抑郁症治疗带来突破，并推动了对γ-氨基丁酸A型受体（gamma-aminobutyric acid type A receptor, GABAAR）调节剂抗抑郁作用机制的深入研究。本文系统综述了14项临床试验，并采用事后分析方法，揭示了布瑞诺龙和舒拉诺龙的临床优势及潜在局限性，为临床应用提供参考。同时，基于布瑞诺龙及其类似物的机制研究进展，提出了3种可能解释其快速、持久抗抑郁作用的假说：神经内分泌学说、神经振荡学说和神经营养因子学说，以期为产后抑郁症药物的研发提供新思路。

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邓雅婷，女，副教授，主要从事抑郁症发病机制与治疗研究。E-mail: dengyating@xiyi.edu.cn。

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邓雅婷，女，副教授，主要从事抑郁症发病机制与治疗研究。E-mail: dengyating@xiyi.edu.cn。

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