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In the past two decades, the technology of compression-coated tablets has developed and progressed rapidly. Particularly, for the stepwise compression-coating technology, both the machine production capacity and the tablets quality have been greatly improved. And because the application of new excipients and new pharmaceutical technology, the prescription design ideas have been much optimized. Zero-order release tablets, pulsatile drug delivery tablets, floating drug delivery tablets, and colonic drug delivery tablets can be produced by compression coating technology, which can make blood drug concentrations more stable, improve the bioavailability of drugs or reduce adverse drug reactions, so the treatment of some diseases can be improved by these drug delivery tablets.

, authors=Xiu-yi CHEN^{1, 2, 3}, Wen ZHANG^{1, 2, 3}, Chao CHEN^{1, 2, 3}, Jing FENG^{1, 2, 3}, Jin-hu WANG^{1, 2}, Zhao-ming LI^{1, 2}, Da-wei LI^{1, 2, 3, *}, authorsList=Xiu-yi CHEN, Wen ZHANG, Chao CHEN, Jing FENG, Jin-hu WANG, Zhao-ming LI, Da-wei LI, authorCompany=null, correspAuthors=Da-wei LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425630642680675, articleId=1321425629749293920, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=压制包衣技术在缓控释制剂中的应用与研究进展, columnId=1236330553964810454, journalTitle=中国新药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

20多年以来，压制包衣技术飞速发展和进步，尤其是分步压制包衣技术，无论是设备生产能力还是其包芯片品质都有极大的改善，而且新辅料的应用也相应提高了处方设计水平。采用压制包衣技术可制备零级释药缓释片、择时脉冲释放片、胃漂浮缓释片和结肠定位释放片等，这对提高药物生物利用度、减少服药次数、降低不良反应、增加顺应性、提高节律性疾病或者胃肠道局部疾病的治疗水平都有非常重要的意义，值得进一步深入研究和产业化探索。

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陈修毅，男，副主任药师，研究方向：药物新制剂技术。E-mail: sdcxy@qq.com。

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