Article(id=1321425621142586358, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425597998420385, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.08.006, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1767715200000, acceptedDateStr=2026-01-07, onlineDate=1792982018981, onlineDateStr=2026-10-26, pubDate=1777478400000, pubDateStr=2026-04-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982018981, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982018981, creator=13701087609, updateTime=1792982018981, updator=13701087609, issue=Issue{id=1321425597998420385, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='8', pageStart='785', pageEnd='896', issueExtLink='null', onlineDate='null', pubDate='1777478400000', pubDateStr='2026-04-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982013463, creator='13701087609', updateTime=1792983113439, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321430211678290797, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425597998420385, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321430211678290798, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425597998420385, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=827, endPage=840, ext={EN=ArticleExt(id=1321425621327135735, articleId=1321425621142586358, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Evolution characteristics and influencing factors of new drug research and development collaboration network in China, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Based on the new drug research and development (R&D) cooperation data of different stages from 2015 to 2021, this study explored the heterogeneity in the composition of entities and spatial structure across different stages of new drug research and development by using social network analysis, negative binomial models and other methods. It identified various types of collaborations in new drug research and development and further discussed the main factors driving such collaborations in China. The main results are as follows: firstly, there are differences in actor composition across various stages of new drug R&D. Universities and research institutions are key actors in the pre-clinical trial phase, whereas enterprises play a dominant role during the clinical trial phase. Secondly, overall, the topological structure of China's new drug R&D collaboration network has evolved from a "dual-core" driven pattern to a "dual-core+multi-polar" driven pattern. The "dual-core" refers to Beijing and Shanghai, while the "multi-polar" nodes include cities such as Suzhou, Guangzhou, Chengdu, and Nanjing. Moreover, the spatial configuration of the collaboration network differs significantly between the pre-clinical and clinical trial phases. Thirdly, in the pre-clinical trial phase, urban R&D collaborations tend to shift from internal to external partnerships, whereas the direction of this shift is reversed during the clinical trial phase. Fourthly, geographical proximity plays a significant role in all stages of new drug R&D collaboration, while factors such as technological and institutional proximity exhibit certain phase-specific and stage-dependent variations.
, authors=Tang-wei TENG, Yi-lan YAN
*, authorsList=Tang-wei TENG, Yi-lan YAN, authorCompany=null, correspAuthors=Yi-lan YAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425621603959800, articleId=1321425621142586358, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=我国新药研发合作网络演化特征及影响因素识别, columnId=1236331162679955859, journalTitle=中国新药杂志, columnName=新药述评与论坛, runingTitle=null, highlight=null, articleAbstract=
选取我国2015—2021年新药研发合作数据,运用社会网络分析、负二项模型等方法,探索了新药研发不同环节在主体构成和空间结构上的分异性,识别城市新药研发合作的不同类型,进一步探讨了驱动我国新药研发合作的主要因素。研究发现:①新药研发各环节主体构成存在差异。大学和科研机构是临床前研究阶段的关键主体类型,企业在临床试验阶段占主导地位;②整体而言,我国新药研发合作网络拓扑结构由“双核”驱动向“双核+多极”驱动演化,其中“双核”指北京市与上海市,“多极”指苏州市、广州市、成都市、南京市等城市。而新药研发合作网络空间格局在临床前研究和临床试验阶段差异较大;③在临床前研究阶段,城市研发合作类型具有由内部转向外部合作的倾向,而临床试验阶段,新药研发合作类型转变方向相反;④地理邻近在新药研发合作的各环节均作用显著,而技术邻近、制度邻近等因素则表现出一定的阶段性差异与环节差异。
, authors=滕堂伟, 闫怡澜
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滕堂伟,男,博士,主要从事集群创新与区域经济发展研究。联系电话:(021)62233639,E-mail: twteng@re.ecnu.edu.cn。
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滕堂伟,男,博士,主要从事集群创新与区域经济发展研究。联系电话:(021)62233639,E-mail: twteng@re.ecnu.edu.cn。
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