Article(id=1321425620643459879, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425597998420385, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.08.010, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1761580800000, acceptedDateStr=2025-10-28, onlineDate=1792982018861, onlineDateStr=2026-10-26, pubDate=1777478400000, pubDateStr=2026-04-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982018861, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982018861, creator=13701087609, updateTime=1792982018861, updator=13701087609, issue=Issue{id=1321425597998420385, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='8', pageStart='785', pageEnd='896', issueExtLink='null', onlineDate='null', pubDate='1777478400000', pubDateStr='2026-04-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982013463, creator='13701087609', updateTime=1792983113439, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321430211678290797, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425597998420385, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321430211678290798, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425597998420385, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=861, endPage=868, ext={EN=ArticleExt(id=1321425621385851688, articleId=1321425620643459879, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Mechanism of action and clinical application of botulinum toxin type A in the treatment of hemifacial spasm, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Hemifacial spasm (HFS) is a movement disorder characterized by involuntary, paroxysmal contractions of the facial muscles, typically caused by compression or demyelination of the facial nerve. It is often associated with facial distortion and twitching, significantly affecting the patient's quality of life. Traditional pharmacological treatments, such as anticonvulsants, benzodiazepines, and muscle relaxants, can provide some symptom relief, but their efficacy is limited, and side effects are prominent. In recent years, botulinum toxin type A (BTX-A) has emerged as the first-line clinical treatment for HFS. BTX-A works by inhibiting acetylcholine release at the nerve terminal, blocking the signal transmission at the neuromuscular junction, and reducing muscle overactivity. Additionally, it modulates the excitability of the central nervous system and improves neural plasticity, facilitating the recovery of facial nerve function and further alleviating HFS symptoms. This article systematically reviews the mechanism of action and clinical research of BTX-A in the treatment of HFS, analyzes current challenges in its use, and explores its future prospects in the treatment of HFS, aiming to provide safer, more effective, and personalized treatment options for HFS patients.

, authors=Rui-bo WANG, Ji-ping ZHAO^*, authorsList=Rui-bo WANG, Ji-ping ZHAO, authorCompany=null, correspAuthors=Ji-ping ZHAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425621897556778, articleId=1321425620643459879, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=A型肉毒毒素制剂治疗面肌痉挛作用机制及临床应用研究, columnId=1236330553964810454, journalTitle=中国新药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

面肌痉挛（hemifacial spasm, HFS）是一种由面神经受压或脱髓鞘导致面部肌肉不自主、阵发性收缩的运动障碍性疾病，常伴有面部扭曲、抽动等症状，严重影响患者生活质量。传统药物治疗如抗癫痫药物、苯二氮[XCZHUOF.TIF]类药物及肌肉松弛剂能够一定程度上缓解症状，但疗效有限，且不良反应明显。近年来，A型肉毒毒素（botulinum toxin type A, BTX-A）成为HFS一线临床治疗方法，其通过抑制神经末梢乙酰胆碱释放，阻断神经-肌肉接头信号传递，减少肌肉过度收缩，还通过调节中枢神经系统兴奋性和改善神经可塑性，促进面神经功能恢复，进一步减轻HFS的症状。本文将重点对BTX-A制剂在治疗HFS中的作用机制及其临床应用研究进行系统综述，分析其当前应用存在的问题，并展望未来其在HFS治疗中的发展前景，以期为HFS患者提供更加安全、有效和个性化的治疗选择。

, authors=王瑞博, 赵吉平^*, authorsList=王瑞博, 赵吉平, authorCompany=null, correspAuthors=赵吉平, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=QuIToWSPVF/ZyEKFh7qtsg==, magXml=9eOrnZ4doC6/jOh7g9S8aw==, pdfUrl=null, pdf=mR0gTRAeqS040kzRbO5fZQ==, pdfFileSize=3352262, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=MkT79/aH/rMg3uWAsfABbw==, mapNumber=null, fund=null)}, authors=[Author(id=1321425623604638511, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425620643459879, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=wrbo1005@163.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425623684330289, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425620643459879, authorId=1321425623604638511, language=EN, stringName=Rui-bo WANG, firstName=Rui-bo, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Acupuncture and Moxibustion, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425623747244850, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425620643459879, authorId=1321425623604638511, language=CN, stringName=王瑞博, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=北京中医药大学东直门医院针灸科，北京 100700, bio={"content":"

王瑞博，女，硕士研究生，主要从事针药结合优势病种的研究。E-mail: wrbo1005@163.com。

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王瑞博，女，硕士研究生，主要从事针药结合优势病种的研究。E-mail: wrbo1005@163.com。

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