Article(id=1321425615958426563, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425597998420385, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.08.002, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1754841600000, acceptedDateStr=2025-08-11, onlineDate=1792982017744, onlineDateStr=2026-10-26, pubDate=1777478400000, pubDateStr=2026-04-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982017744, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982017744, creator=13701087609, updateTime=1792982017744, updator=13701087609, issue=Issue{id=1321425597998420385, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='8', pageStart='785', pageEnd='896', issueExtLink='null', onlineDate='null', pubDate='1777478400000', pubDateStr='2026-04-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982013463, creator='13701087609', updateTime=1792983113439, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321430211678290797, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425597998420385, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321430211678290798, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425597998420385, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=795, endPage=803, ext={EN=ArticleExt(id=1321425616117810116, articleId=1321425615958426563, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Design strategies of targeted nano-drug delivery systems and advances in tumor precision therapy, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Targeted nano-drug delivery systems (NDDS) have provided a new strategy for the precise therapy of tumor. NDDS, as novel modes of drug delivery, are capable of penetrating various biological barriers to deliver therapeutic agents precisely to tumor sites. By leveraging their unique size effect, controlled release, stimulation response, ease of modification and functionalization, these systems enhance drug stability and solubility, improve bioavailability, and reduce systemic toxicity and side effects. Consequently, they enable targeted drug delivery and theranostics, offering promising solutions to overcome the therapeutic limitations of conventional chemotherapeutic agents. This paper summarizes the advantages of NDDS, the classification, principles and targeted design strategies of nano-carriers, focuses on the types of commonly used targeting ligands and their mechanisms of action, analyzes the current developments and challenges in scalable production, in vivo transport, biocompatibility and clinical translation, and looks forward to the prospects of future applications, with the aim of providing references for the further development and clinical applications.

, authors=Yun ZHANG, Yu ZHENG, Ning XU, Ya-li ZHANG, Nan YANG, Bin-yu MA, authorsList=Yun ZHANG, Yu ZHENG, Ning XU, Ya-li ZHANG, Nan YANG, Bin-yu MA, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425616335913925, articleId=1321425615958426563, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=靶向纳米递药系统设计策略及其在肿瘤精准治疗中的研究进展, columnId=1321425598828892579, journalTitle=中国新药杂志, columnName=靶向纳米递药系统研究进展, runingTitle=null, highlight=null, articleAbstract=

靶向纳米递药系统为肿瘤的精准治疗提供了新策略，其作为一种新型给药方式，能够穿透各种生物屏障将药物精准递送至病灶部位，利用其独特的尺寸效应、控制释放、刺激响应、易修饰与功能化等优势，增加药物稳定性与溶解度，提高生物利用度，减少不良反应，实现药物的靶向递送与诊疗一体化，有望突破传统化疗药物的治疗瓶颈。本文总结纳米递药系统的优势以及纳米载体的分类、原理和靶向设计策略，重点探讨常用靶向配体的类型及其作用机制，剖析其在规模化生产、体内转运、生物相容性和临床转化等方面的发展现状与面临挑战，并展望了未来应用前景，旨在为纳米递药系统的深入开发及其临床应用提供参考。

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张韫，女，硕士，副教授，研究方向：新型纳米药物递送系统。E-mail: z1987730@163.com。

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张韫，女，硕士，副教授，研究方向：新型纳米药物递送系统。E-mail: z1987730@163.com。

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