Article(id=1321425606349279724, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425597998420385, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.08.013, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1750089600000, acceptedDateStr=2025-06-17, onlineDate=1792982015454, onlineDateStr=2026-10-26, pubDate=1777478400000, pubDateStr=2026-04-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982015454, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982015454, creator=13701087609, updateTime=1792982015454, updator=13701087609, issue=Issue{id=1321425597998420385, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='8', pageStart='785', pageEnd='896', issueExtLink='null', onlineDate='null', pubDate='1777478400000', pubDateStr='2026-04-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982013463, creator='13701087609', updateTime=1792983113439, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321430211678290797, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425597998420385, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321430211678290798, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425597998420385, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=882, endPage=888, ext={EN=ArticleExt(id=1321425606554800621, articleId=1321425606349279724, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Quality standard study of Qi Feng Er Teng Granules, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective:

To establish the identification and content determination methods of Qi Feng Er Teng Granules.

Methods:

TLC was used for identification and HPLC was used for content determination.

Results:

The TLC method allowed effective identification of all crude drugs in the formulation. The calibration curves of paeoniflorin, prim-O-glucosylcimifugin, calycosin-7-glucoside, 5-O-methylvisammioside, icariin, sinomenine, and astragaloside IV showed good linearity in the range of 9.01~45.1, 1.69~8.44, 1.04~5.20, 1.32~6.59, 4.35~21.7, 13.5~67.5, 101~506 μg·mL-1, respectively. The average recovery rate of sample addition was within the range of 95.0% to 105.0% (RSD<3.2%).

Conclusion:

The TLC and HPLC methods established in this study for Qi Feng Er Teng Granules have strong specificity, high sensitivity and good reproducibility, and can be used for the quality control of Qi Feng Er Teng Granules.

, authors=Pei-pei LIANG1, You-chen LI1, Xin-yu WANG1, Bin LIU1, 2, *, authorsList=Pei-pei LIANG, You-chen LI, Xin-yu WANG, Bin LIU, authorCompany=null, correspAuthors=Bin LIU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425606802264558, articleId=1321425606349279724, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=芪风二藤颗粒质量标准研究, columnId=1236330556003242277, journalTitle=中国新药杂志, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的:

建立芪风二藤颗粒的薄层鉴别与含量测定方法。

方法:

鉴别采用TLC法,含量测定采用HPLC法。

结果:

TLC鉴别方法能够有效鉴别处方中所有药材。HPLC法测定芍药苷、升麻素苷、毛蕊异黄酮苷、5-O-甲基维斯阿米醇苷、淫羊藿苷、青藤碱、黄芪甲苷质量浓度分别在9.01~45.1、1.69~8.44、1.04~5.20、1.32~6.59、4.35~21.7、13.5~67.5、101~506 μg·mL-1范围内线性关系良好;平均加样回收率均在95.0%~105.0%范围内(RSD<3.2%)。

结论:

本研究建立的薄层鉴别方法和含量测定方法均专属性强、重现性好,可用于芪风二藤颗粒的质量控制。

, authors=梁珮珮1, 李幼辰1, 王欣钰1, 刘斌1, 2, *, authorsList=梁珮珮, 李幼辰, 王欣钰, 刘斌, authorCompany=null, correspAuthors=刘斌, authorNote=

梁珮珮,女,硕士研究生,研究方向:中药(复方)有效成分(组分)发现与新药创制。E-mail: 。

, correspAuthorsNote=
* 刘斌,男,教授,博士生导师,研究方向:中药(复方)有效成分(组分)发现与新药创制。E-mail: 。
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梁珮珮,女,硕士研究生,研究方向:中药(复方)有效成分(组分)发现与新药创制。E-mail: 。

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梁珮珮,女,硕士研究生,研究方向:中药(复方)有效成分(组分)发现与新药创制。E-mail: 。

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芪风二藤颗粒质量标准研究
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梁珮珮 1 , 李幼辰 1 , 王欣钰 1 , 刘斌 1, 2, *
中国新药杂志 | 实验研究 2026,35(8): 882-888
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中国新药杂志 |实验研究 2026 , 35 (8) : 882 -888
芪风二藤颗粒质量标准研究
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梁珮珮1 , 李幼辰1, 王欣钰1, 刘斌1, 2, *
作者信息
  • 1北京中医药大学中药学院,北京 102488
  • 2国家中医药管理局中药经典名方有效物质发现重点研究室,北京 102488
通讯作者:
* 刘斌,男,教授,博士生导师,研究方向:中药(复方)有效成分(组分)发现与新药创制。E-mail: 。
作者简介:

梁珮珮,女,硕士研究生,研究方向:中药(复方)有效成分(组分)发现与新药创制。E-mail: 。

Quality standard study of Qi Feng Er Teng Granules
Pei-pei LIANG1 , You-chen LI1, Xin-yu WANG1, Bin LIU1, 2, *
Affiliations
  • 1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China
  • 2Key Laboratory of Discovery of Effective Substances in Classical Prescriptions of Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, Beijing 102488, China
出版时间: 2026-04-30 doi: 10.20251/j.cnki.1003-3734.2026.08.013
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目的:

建立芪风二藤颗粒的薄层鉴别与含量测定方法。

方法:

鉴别采用TLC法,含量测定采用HPLC法。

结果:

TLC鉴别方法能够有效鉴别处方中所有药材。HPLC法测定芍药苷、升麻素苷、毛蕊异黄酮苷、5-O-甲基维斯阿米醇苷、淫羊藿苷、青藤碱、黄芪甲苷质量浓度分别在9.01~45.1、1.69~8.44、1.04~5.20、1.32~6.59、4.35~21.7、13.5~67.5、101~506 μg·mL-1范围内线性关系良好;平均加样回收率均在95.0%~105.0%范围内(RSD<3.2%)。

结论:

本研究建立的薄层鉴别方法和含量测定方法均专属性强、重现性好,可用于芪风二藤颗粒的质量控制。

芪风二藤颗粒  /  TLC法  /  HPLC法  /  质量标准
Objective:

To establish the identification and content determination methods of Qi Feng Er Teng Granules.

Methods:

TLC was used for identification and HPLC was used for content determination.

Results:

The TLC method allowed effective identification of all crude drugs in the formulation. The calibration curves of paeoniflorin, prim-O-glucosylcimifugin, calycosin-7-glucoside, 5-O-methylvisammioside, icariin, sinomenine, and astragaloside IV showed good linearity in the range of 9.01~45.1, 1.69~8.44, 1.04~5.20, 1.32~6.59, 4.35~21.7, 13.5~67.5, 101~506 μg·mL-1, respectively. The average recovery rate of sample addition was within the range of 95.0% to 105.0% (RSD<3.2%).

Conclusion:

The TLC and HPLC methods established in this study for Qi Feng Er Teng Granules have strong specificity, high sensitivity and good reproducibility, and can be used for the quality control of Qi Feng Er Teng Granules.

Qi Feng Er Teng Granules  /  TLC method  /  HPLC method  /  quality standard
梁珮珮, 李幼辰, 王欣钰, 刘斌. 芪风二藤颗粒质量标准研究. 中国新药杂志, 2026 , 35 (8) : 882 -888 . DOI: 10.20251/j.cnki.1003-3734.2026.08.013
Pei-pei LIANG, You-chen LI, Xin-yu WANG, Bin LIU. Quality standard study of Qi Feng Er Teng Granules[J]. Chinese Journal of New Drugs, 2026 , 35 (8) : 882 -888 . DOI: 10.20251/j.cnki.1003-3734.2026.08.013

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2026年第35卷第8期
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doi: 10.20251/j.cnki.1003-3734.2026.08.013
  • 首发时间:2026-10-26
  • 出版时间:2026-04-30
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  • 录用日期:2025-06-17
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    1北京中医药大学中药学院,北京 102488
    2国家中医药管理局中药经典名方有效物质发现重点研究室,北京 102488

通讯作者:

* 刘斌,男,教授,博士生导师,研究方向:中药(复方)有效成分(组分)发现与新药创制。E-mail: 。
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2种不同金属材料的力学参数
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属
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species
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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