Article(id=1321425598547874209, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425597998420385, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.08.001, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1749398400000, acceptedDateStr=2025-06-09, onlineDate=1792982013593, onlineDateStr=2026-10-26, pubDate=1777478400000, pubDateStr=2026-04-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982013593, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982013593, creator=13701087609, updateTime=1792982013593, updator=13701087609, issue=Issue{id=1321425597998420385, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='8', pageStart='785', pageEnd='896', issueExtLink='null', onlineDate='null', pubDate='1777478400000', pubDateStr='2026-04-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982013463, creator='13701087609', updateTime=1792983113439, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321430211678290797, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425597998420385, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321430211678290798, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425597998420385, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=785, endPage=794, ext={EN=ArticleExt(id=1321425598736617890, articleId=1321425598547874209, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Advances in surface-functionalized brain-targeted nano-drug delivery systems, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Central nervous system (CNS) diseases have become a major global public health challenge. With the extension of human lifespan and the intensification of population aging, the incidence of these diseases has shown a significant upward trend, yet their clinical treatment still faces critical technological bottlenecks. The presence of the blood-brain barrier (BBB) hinders the delivery of over 98% of small-molecule drugs and nearly all macromolecular drugs into the brain, rendering conventional drug administration methods unable to achieve effective therapeutic concentrations. In recent years, brain-targeted nano-drug delivery systems based on nanotechnology have demonstrated breakthrough potential: nanocarriers can improve the efficiency of drug crossing the BBB through size effects; surface functional modifications enable precise drug delivery to the brain. This article describes the composition and function of the BBB, the types of nanocarriers, and brain-targeting strategies via functional group modifications, aiming to provide theoretical foundations and technical references for developing safe and efficient brain-targeted nano-drug delivery systems.

, authors=Yu ZHANG¹, Sheng-nan LU², Jun-li ZHANG¹, Yao-yao ZHANG³, Ling CHENG³, Jing LI³, Ying LI², Feng SU^{1, 2, 3, *}, Guang-wei HE^{1, 2, 3, *}, authorsList=Yu ZHANG, Sheng-nan LU, Jun-li ZHANG, Yao-yao ZHANG, Ling CHENG, Jing LI, Ying LI, Feng SU, Guang-wei HE, authorCompany=null, correspAuthors=Feng SU, Guang-wei HE, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425599021830564, articleId=1321425598547874209, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=功能基修饰的脑靶向纳米递药系统研究进展, columnId=1321425598828892579, journalTitle=中国新药杂志, columnName=靶向纳米递药系统研究进展, runingTitle=null, highlight=null, articleAbstract=

中枢神经系统疾病已成为当今全球公共卫生领域的重大挑战。随着人类寿命延长和人口老龄化加剧，该类疾病的发病率呈显著上升趋势，但其临床治疗仍面临关键性技术瓶颈。由于血脑屏障的存在，阻碍了超过98%的小分子药物和几乎所有大分子药物的脑内递送，导致常规给药方式难以达到有效治疗浓度。近年来，基于纳米技术构建的脑靶向纳米递药系统展现出突破性潜力：纳米载体可通过尺寸效应提高药物跨越血脑屏障的效率；通过表面功能基修饰可实现脑部精准递送。本文描述了血脑屏障的组成及作用、纳米载体的类型和功能基修饰的脑靶向策略，旨在为开发安全、高效的脑靶向纳米递药系统提供理论依据和技术参考。

, authors=张宇¹, 鲁胜男², 张俊丽¹, 张瑶瑶³, 程玲³, 李静³, 李颖², 苏峰^{1, 2, 3, *}, 何广卫^{1, 2, 3, *}, authorsList=张宇, 鲁胜男, 张俊丽, 张瑶瑶, 程玲, 李静, 李颖, 苏峰, 何广卫, authorCompany=null, correspAuthors=苏峰, 何广卫, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=vVCD42eSAZvJrq4UP1pXqg==, magXml=VjvxY6fNBDK//SxBMfkcYw==, pdfUrl=null, pdf=K8RrbVJ8shkitQ6HMy53hg==, pdfFileSize=2068227, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=9JksLue2bTccCTfO9q7rRw==, mapNumber=null, fund=null)}, authors=[Author(id=1321425601131565488, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=1531144270@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425601207062962, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, authorId=1321425601131565488, language=EN, stringName=Yu ZHANG, firstName=Yu, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=¹School of Pharmaceutical Sciences, Anhui Medical University, Hefei 230032, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425601278366131, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, authorId=1321425601131565488, language=CN, stringName=张宇, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=¹安徽医科大学药学科学学院，合肥 230032, bio={"content":"

张宇，男，硕士研究生，主要从事新剂型与新技术研究。E-mail: 1531144270@qq.com。

"}, bioImg=null, bioContent=

张宇，男，硕士研究生，主要从事新剂型与新技术研究。E-mail: 1531144270@qq.com。

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425599218962853, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, xref=1, ext=[AuthorCompanyExt(id=1321425599235740070, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425599218962853, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹School of Pharmaceutical Sciences, Anhui Medical University, Hefei 230032, China), AuthorCompanyExt(id=1321425599244128679, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425599218962853, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹安徽医科大学药学科学学院，合肥 230032)])]), Author(id=1321425601387418037, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425601471304119, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, authorId=1321425601387418037, language=EN, stringName=Sheng-nan LU, firstName=Sheng-nan, middleName=null, lastName=LU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=²Hefei Industrial Pharmaceutical Institute Co., Ltd., Anhui Provincial Key Laboratory of Drug Innovation and Advanced Pharmaceuticals, Hefei 230088, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425601550995896, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, authorId=1321425601387418037, language=CN, stringName=鲁胜男, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=²合肥医工医药股份有限公司，安徽省药物创新与高端制剂重点实验室，合肥 230088, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425600896684457, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, xref=2, ext=[AuthorCompanyExt(id=1321425600909267370, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425600896684457, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²Hefei Industrial Pharmaceutical Institute Co., Ltd., Anhui Provincial Key Laboratory of Drug Innovation and Advanced Pharmaceuticals, Hefei 230088, China), AuthorCompanyExt(id=1321425600917655979, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425600896684457, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²合肥医工医药股份有限公司，安徽省药物创新与高端制剂重点实验室，合肥 230088)])]), Author(id=1321425601622299066, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425601697796540, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, authorId=1321425601622299066, language=EN, stringName=Jun-li ZHANG, firstName=Jun-li, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=¹School of Pharmaceutical Sciences, Anhui Medical University, Hefei 230032, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425601777488317, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, authorId=1321425601622299066, language=CN, stringName=张俊丽, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=¹安徽医科大学药学科学学院，合肥 230032, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425599218962853, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, xref=1, ext=[AuthorCompanyExt(id=1321425599235740070, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425599218962853, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹School of Pharmaceutical Sciences, Anhui Medical University, Hefei 230032, China), AuthorCompanyExt(id=1321425599244128679, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425599218962853, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹安徽医科大学药学科学学院，合肥 230032)])]), Author(id=1321425601861374399, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425601957843393, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, authorId=1321425601861374399, language=EN, stringName=Yao-yao ZHANG, firstName=Yao-yao, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=³, address=³School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425602020757954, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, authorId=1321425601861374399, language=CN, stringName=张瑶瑶, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=³, address=³中国药科大学药学院，南京 211198, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425601060262316, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, xref=3, ext=[AuthorCompanyExt(id=1321425601068650925, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425601060262316, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=³School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China), AuthorCompanyExt(id=1321425601077039534, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425601060262316, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=³中国药科大学药学院，南京 211198)])]), Author(id=1321425602092061124, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425602171752902, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, authorId=1321425602092061124, language=EN, stringName=Ling CHENG, firstName=Ling, middleName=null, lastName=CHENG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=³, address=³School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425602243056071, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, authorId=1321425602092061124, language=CN, stringName=程玲, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=³, address=³中国药科大学药学院，南京 211198, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425601060262316, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, xref=3, ext=[AuthorCompanyExt(id=1321425601068650925, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425601060262316, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=³School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China), AuthorCompanyExt(id=1321425601077039534, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425601060262316, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=³中国药科大学药学院，南京 211198)])]), Author(id=1321425602310164937, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425602402439627, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, authorId=1321425602310164937, language=EN, stringName=Jing LI, firstName=Jing, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=³, address=³School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425602490520012, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, authorId=1321425602310164937, language=CN, stringName=李静, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=³, address=³中国药科大学药学院，南京 211198, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425601060262316, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, xref=3, ext=[AuthorCompanyExt(id=1321425601068650925, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425601060262316, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=³School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China), AuthorCompanyExt(id=1321425601077039534, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425601060262316, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=³中国药科大学药学院，南京 211198)])]), Author(id=1321425602557628878, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1321425602616349136, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, authorId=1321425602557628878, language=EN, stringName=Ying LI, firstName=Ying, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=²Hefei Industrial Pharmaceutical Institute Co., Ltd., Anhui Provincial Key Laboratory of Drug Innovation and Advanced Pharmaceuticals, Hefei 230088, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425602717012433, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, authorId=1321425602557628878, language=CN, stringName=李颖, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=²合肥医工医药股份有限公司，安徽省药物创新与高端制剂重点实验室，合肥 230088, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425600896684457, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, xref=2, ext=[AuthorCompanyExt(id=1321425600909267370, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425600896684457, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²Hefei Industrial Pharmaceutical Institute Co., Ltd., Anhui Provincial Key Laboratory of Drug Innovation and Advanced Pharmaceuticals, Hefei 230088, China), AuthorCompanyExt(id=1321425600917655979, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425600896684457, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²合肥医工医药股份有限公司，安徽省药物创新与高端制剂重点实验室，合肥 230088)])]), Author(id=1321425602805092819, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, orderNo=7, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=windycpu@sina.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1321425602897367511, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, authorId=1321425602805092819, language=EN, stringName=Feng SU, firstName=Feng, middleName=null, lastName=SU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2, 3, *}, address=¹School of Pharmaceutical Sciences, Anhui Medical University, Hefei 230032, China
²Hefei Industrial Pharmaceutical Institute Co., Ltd., Anhui Provincial Key Laboratory of Drug Innovation and Advanced Pharmaceuticals, Hefei 230088, China
³School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425602981253592, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, authorId=1321425602805092819, language=CN, stringName=苏峰, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2, 3, *}, address=¹安徽医科大学药学科学学院，合肥 230032
²合肥医工医药股份有限公司，安徽省药物创新与高端制剂重点实验室，合肥 230088
³中国药科大学药学院，南京 211198, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425599218962853, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, xref=1, ext=[AuthorCompanyExt(id=1321425599235740070, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425599218962853, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹School of Pharmaceutical Sciences, Anhui Medical University, Hefei 230032, China), AuthorCompanyExt(id=1321425599244128679, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425599218962853, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹安徽医科大学药学科学学院，合肥 230032)]), AuthorCompany(id=1321425600896684457, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, xref=2, ext=[AuthorCompanyExt(id=1321425600909267370, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425600896684457, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²Hefei Industrial Pharmaceutical Institute Co., Ltd., Anhui Provincial Key Laboratory of Drug Innovation and Advanced Pharmaceuticals, Hefei 230088, China), AuthorCompanyExt(id=1321425600917655979, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425600896684457, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²合肥医工医药股份有限公司，安徽省药物创新与高端制剂重点实验室，合肥 230088)]), AuthorCompany(id=1321425601060262316, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, xref=3, ext=[AuthorCompanyExt(id=1321425601068650925, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425601060262316, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=³School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China), AuthorCompanyExt(id=1321425601077039534, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425601060262316, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=³中国药科大学药学院，南京 211198)])]), Author(id=1321425603048362458, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, orderNo=8, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=hgwhipi@hotmail.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1321425603149025758, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, authorId=1321425603048362458, language=EN, stringName=Guang-wei HE, firstName=Guang-wei, middleName=null, lastName=HE, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2, 3, *}, address=¹School of Pharmaceutical Sciences, Anhui Medical University, Hefei 230032, China
²Hefei Industrial Pharmaceutical Institute Co., Ltd., Anhui Provincial Key Laboratory of Drug Innovation and Advanced Pharmaceuticals, Hefei 230088, China
³School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1321425603237106143, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, authorId=1321425603048362458, language=CN, stringName=何广卫, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2, 3, *}, address=¹安徽医科大学药学科学学院，合肥 230032
²合肥医工医药股份有限公司，安徽省药物创新与高端制剂重点实验室，合肥 230088
³中国药科大学药学院，南京 211198, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1321425599218962853, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, xref=1, ext=[AuthorCompanyExt(id=1321425599235740070, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425599218962853, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹School of Pharmaceutical Sciences, Anhui Medical University, Hefei 230032, China), AuthorCompanyExt(id=1321425599244128679, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425599218962853, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹安徽医科大学药学科学学院，合肥 230032)]), AuthorCompany(id=1321425600896684457, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, xref=2, ext=[AuthorCompanyExt(id=1321425600909267370, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425600896684457, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²Hefei Industrial Pharmaceutical Institute Co., Ltd., Anhui Provincial Key Laboratory of Drug Innovation and Advanced Pharmaceuticals, Hefei 230088, China), AuthorCompanyExt(id=1321425600917655979, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425600896684457, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²合肥医工医药股份有限公司，安徽省药物创新与高端制剂重点实验室，合肥 230088)]), AuthorCompany(id=1321425601060262316, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, xref=3, ext=[AuthorCompanyExt(id=1321425601068650925, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425601060262316, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=³School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China), AuthorCompanyExt(id=1321425601077039534, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425601060262316, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=³中国药科大学药学院，南京 211198)])])], keywords=[Keyword(id=1321425603350352352, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, language=EN, orderNo=1, keyword=nano-drug delivery system), Keyword(id=1321425603438432737, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, language=EN, orderNo=2, keyword=brain-targeting), Keyword(id=1321425603509735906, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, language=EN, orderNo=3, keyword=functional group ligand), Keyword(id=1321425603602010595, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, language=EN, orderNo=4, keyword=blood-brain barrier), Keyword(id=1321425603677508068, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, language=EN, orderNo=5, keyword=nanocarriers), Keyword(id=1321425603815920101, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, language=EN, orderNo=6, keyword=central nervous system), Keyword(id=1321425605434921446, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, language=CN, orderNo=1, keyword=纳米递药系统), Keyword(id=1321425605535584743, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, language=CN, orderNo=2, keyword=脑靶向), Keyword(id=1321425605623665128, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, language=CN, orderNo=3, keyword=功能基配体), Keyword(id=1321425605707551209, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, language=CN, orderNo=4, keyword=血脑屏障), Keyword(id=1321425605778854378, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, language=CN, orderNo=5, keyword=纳米载体), Keyword(id=1321425605858546155, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, language=CN, orderNo=6, keyword=中枢神经系统)], refs=null, funds=null, companyList=[AuthorCompany(id=1321425599218962853, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, xref=1, ext=[AuthorCompanyExt(id=1321425599235740070, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425599218962853, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹School of Pharmaceutical Sciences, Anhui Medical University, Hefei 230032, China), AuthorCompanyExt(id=1321425599244128679, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425599218962853, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹安徽医科大学药学科学学院，合肥 230032)]), AuthorCompany(id=1321425600896684457, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, xref=2, ext=[AuthorCompanyExt(id=1321425600909267370, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425600896684457, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²Hefei Industrial Pharmaceutical Institute Co., Ltd., Anhui Provincial Key Laboratory of Drug Innovation and Advanced Pharmaceuticals, Hefei 230088, China), AuthorCompanyExt(id=1321425600917655979, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425600896684457, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²合肥医工医药股份有限公司，安徽省药物创新与高端制剂重点实验室，合肥 230088)]), AuthorCompany(id=1321425601060262316, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, xref=3, ext=[AuthorCompanyExt(id=1321425601068650925, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425601060262316, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=³School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China), AuthorCompanyExt(id=1321425601077039534, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1321425598547874209, companyId=1321425601060262316, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=³中国药科大学药学院，南京 211198)])], figs=null, attaches=null, journal=Journal(id=1235980159023624194, delFlag=0, nameCn=中国新药杂志, nameEn=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, issn=1003-3734, eissn=null, cn=11-2850/R, coden=ZXZHA6, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of New Drugs, journalRemark=null, publicationField=null, createdTime=1772610233314, updatedTime=1788948968376, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=ohPEEN//Vz1tDT3ZBNTp4Q==, picEn=f9WK9bvTM4guTmS/iGhOMg==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509780974924039, language=CN, name=中国新药杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948968404, updatedTime=1788948968404, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304509781025255688, language=EN, name=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948968416, updatedTime=1788948968416, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1235980733773295621, websiteList=[Website(id=1235982099191222761, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/CN, language=CN, createTime=1772610695884, createBy=18614031015, updateTime=1772610860397, updateBy=18614031015, name=中国新药杂志-中文, tplId=1146099689490845704, title=中国新药杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983918629966444, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=articleTextType, value=kx, createTime=1772611129672, updateTime=1772611129672, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918604800617, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=banner, value=null, createTime=1772611129666, updateTime=1772611129666, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918655132271, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=grayFlag, value=0, createTime=1772611129678, updateTime=1772611129678, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918596412008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611129664, updateTime=1772611129664, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918667715185, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=minRunFlag, value=0, createTime=1772611129681, updateTime=1772611129681, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918617383531, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic, createTime=1772611129669, updateTime=1772611129669, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918659326576, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=silenceFlag, value=0, createTime=1772611129679, updateTime=1772611129679, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918613189226, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1772611129668, updateTime=1772611129668, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918634160749, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeColor, value=null, createTime=1772611129673, updateTime=1772611129673, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918646743662, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeStyle, value=null, createTime=1772611129676, updateTime=1772611129676, creator=18614031015, updator=18614031015)]), Website(id=1235982099270914542, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/EN, language=EN, createTime=1772610695903, createBy=18614031015, updateTime=1772610875891, updateBy=18614031015, name=中国新药杂志-英文, tplId=1146101810881728533, title=Chinese Journal of New Drugs, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983955829248630, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=articleTextType, value=kx, createTime=1772611138541, updateTime=1772611138541, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955804082803, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=banner, value=null, createTime=1772611138535, updateTime=1772611138535, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955854414457, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=grayFlag, value=0, createTime=1772611138547, updateTime=1772611138547, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955795694194, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611138533, updateTime=1772611138533, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955866997371, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=minRunFlag, value=0, createTime=1772611138550, updateTime=1772611138550, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955820860021, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic, createTime=1772611138539, updateTime=1772611138539, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955862803066, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=silenceFlag, value=0, createTime=1772611138549, updateTime=1772611138549, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955812471412, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1772611138537, updateTime=1772611138537, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955837637239, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeColor, value=null, createTime=1772611138543, updateTime=1772611138543, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955846025848, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeStyle, value=null, createTime=1772611138545, updateTime=1772611138545, creator=18614031015, updator=18614031015)])], journalTitle=中国新药杂志, weixinUrl=null, journalUrl=http://www.newdrug.cn/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of New Drugs, journalPhotoCn=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPhotoEn=f9WK9bvTM4guTmS/iGhOMg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/10.20251/j.cnki.1003-3734.2026.08.001, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/10.20251/j.cnki.1003-3734.2026.08.001, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/PDF/10.20251/j.cnki.1003-3734.2026.08.001, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/PDF/10.20251/j.cnki.1003-3734.2026.08.001, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1777478400000, fullTextJson=null, articleText=null, reference=null)