Article(id=1321425589999874648, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425569611362746, articleNumber=null, orderNo=null, doi=10.20251/j.cnki.1003-3734.2026.07.010, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1750953600000, acceptedDateStr=2025-06-27, onlineDate=1792982011556, onlineDateStr=2026-10-26, pubDate=1776182400000, pubDateStr=2026-04-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792982011556, onlineIssueDateStr=2026-10-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792982011556, creator=13701087609, updateTime=1792982011556, updator=13701087609, issue=Issue{id=1321425569611362746, tenantId=1146029695717560320, journalId=1235980733773295621, year='2026', volume='35', issue='7', pageStart='673', pageEnd='784', issueExtLink='null', onlineDate='null', pubDate='1776182400000', pubDateStr='2026-04-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1792982006695, creator='13701087609', updateTime=1792983136833, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1321430309837587328, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425569611362746, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1321430309837587329, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1321425569611362746, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=741, endPage=748, ext={EN=ArticleExt(id=1321425592105415261, articleId=1321425589999874648, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Exploring the therapeutic effects and underlying mechanisms of Tibetan medicine Xiaoboyuganzi decoction on type 2 diabetes mellitus via network pharmacology, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To investigate the potential active ingredients and mechanism of action of Xiaobo Yuganzi Ddecoction in the treatment of type 2 diabetes mellitus (T2DM).
Methods: UPLC-Q-Exactive Orbitrap MS was employed to characterize the chemical constituents of Xiaobo Yuganzi Decoction. Potential targets of these chemical constituents and known T2DM-related targets were retrieved from public databases, and their overlapping targets were identified. A protein-protein interaction network was constructed to screen for core targets, followed by gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis. Cytoscape 3.9.1 software was utilized to construct a ‘drug-constituent-target-pathway’ network, and molecular docking was performed between chemical constituents and key targets to screen for potential active ingredients. Western blotting was employed to investigate the effects of Xiaobo Yuganzi Decoction on the expression levels of proteins related to the PI3K/AKT pathway in HepG2 cells.
Results: A total of 39 chemical constituents were identified in Xiaobo Yuganzi Decoction, and 443 intersecting targets were obtained. These targets were primarily involved in biological processes such as protein phosphorylation. Molecular docking results indicated that jatrorrhizine, berberine, ellagic acid, bufotenidine, bufotenine, and palmatine exhibited good binding affinities to key protein receptors. Compared with the model group, Xiaobo Yuganzi Decoction significantly upregulated the expression of p-PI3K/PI3K and p-AKT/AKT proteins in HepG2 cells (P<0.05), consistent with the predictions from network pharmacology.
Conclusion: Potential active ingredients in Xiaobo Yuganzi Decoction, such as jatrorrhizine and ellagic acid, may target core proteins including SRC, HSP90AA1, and STAT3, thereby modulating the PI3K/AKT signaling pathway to exert therapeutic effects on T2DM.
, authors=Mei-gui TIAN
1, Yi ZONG
2, Jia-yan PENG
2, Xue-mei HUANG
2, Shuang-feng XIONG
2, Jing ZHANG
2, Gang FAN
2, *, authorsList=Mei-gui TIAN, Yi ZONG, Jia-yan PENG, Xue-mei HUANG, Shuang-feng XIONG, Jing ZHANG, Gang FAN, authorCompany=null, correspAuthors=Gang FAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1321425592948470367, articleId=1321425589999874648, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=利用网络药理学探索藏药小檗余甘子汤治疗2型糖尿病的作用及相关机制, columnId=1236330556003242277, journalTitle=中国新药杂志, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的： 探究小檗余甘子汤治疗2型糖尿病（type 2 diabetes mellitus, T2DM）的潜在活性成分及作用机制。
方法： 采用超高效液相色谱-四极杆-静电场轨道阱质谱（UPLC-Q-Exactive Orbitrap MS）技术鉴定小檗余甘子汤所含化学成分。利用数据库获取化学成分与疾病靶点，合并收集交集靶点。构建蛋白互作网络，筛选核心靶点，并对潜在靶点进行基因本体（gene ontology, GO）和京都基因与基因组百科全书（Kyoto encyclopedia of genes and genomes, KEGG）富集分析。采用Cytoscape 3.9.1软件构建“药物-成分-靶点-通路”网络，将化学成分与关键靶点进行分子对接，筛选潜在活性成分。采用Western blotting研究小檗余甘子汤对HepG2细胞PI3K/AKT通路相关蛋白表达的影响。
结果： 小檗余甘子汤共鉴定39个化学成分，得到交集靶点443个，主要参与蛋白磷酸化等生物过程。分子对接结果发现，药根碱、小檗碱、鞣花酸、蟾蜍特尼定、蟾毒色胺和巴马汀与关键蛋白受体结合较优。与模型组相比，小檗余甘子汤能显著上调HepG2细胞p-PI3K/PI3K和p-AKT/AKT蛋白的表达（P<0.05），这与网络药理学预测结果相吻合。
结论： 小檗余甘子汤中药根碱、鞣花酸等潜在活性成分，可能作用于SRC、HSP90AA1、STAT3等核心靶点，通过调控PI3K/AKT信号通路发挥改善T2DM的作用。
, authors=田玫瑰
1, 宗毅
2, 彭家艳
2, 黄雪梅
2, 熊双凤
2, 张静
2, 范刚
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田玫瑰，女，学士，讲师，研究方向：中药质量控制及物质基础研究。E-mail: 158933248@qq.com。
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