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Lonapegsomatropin-tcgd (tradename: Skytrofa^TM) is the first long-acting new drug approved by FDA for the treatment of growth hormone deficiency in children. It can continuously release growth hormone and needs to be injected for only once a week. Lonapegsomatropin-tcpd improves patient compliance by reducing dosing frequency compared to traditional daily somatropin injection therapy. Clinical studies confirmed that weekly treatment of lonapegsomatropin-tcpd showed a higher annual growth velocity at week 52 compared with somatropin. In this article, the mechanism, pharmacokinetics, pharmacodynamics, clinical evaluation, safety, drug interaction and storage of lonapegsomatropin-tcpd are reviewed.

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lonapegsomatropin-tcgd（商品名：Skytrofa^TM）是美国FDA批准的第1款用于儿童生长激素缺乏症治疗的长效制剂，可在1周内持续释放生长激素，每周仅需注射1次。与传统的每日注射生长激素疗法相比，lonapegsomatropin-tcpd可通过降低给药频次提升患者依从性，从而改善治疗效果。临床研究证实，与生长激素相比，每周1次的lonapegsomatropin-tcpd在第52周显示出更高的年化身高增长速率。本文就lonapegsomatropin-tcgd的作用机制、药动学、临床疗效、安全性、药物相互作用等方面进行述评。

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秦硕，男，药师，主要从事临床药动学研究。联系电话：(010)69156513，E-mail: shuoshuo2003@163.com。

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秦硕，男，药师，主要从事临床药动学研究。联系电话：(010)69156513，E-mail: shuoshuo2003@163.com。

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