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Recently, radioimmunotherapy (RIT) has attracted much attention because of its precision targeted therapy. It is a therapeutic mode with great clinical application value to select an appropriate target molecule for radioimmunotherapy. B7-H3, also known as CD276, is an immune checkpoint molecule belonging to the B7 immunoglobin superfamily, which makes it an ideal candidate for RIT agents due to its unique expression characteristics and biological functions. Herein, we summarize the expression characteristics and biological functions of B7-H3. We also review the latest developments in radioimmunotherapy targeting B7-H3 in the context of cancer therapeutic.

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近年来，放射免疫治疗（radioimmunotherapy, RIT）因其精准靶向治疗而备受关注。寻找特异性免疫治疗靶点分子用于放射免疫治疗是一种极具临床应用价值的治疗模式。B7-H3（CD276）是B7家族中的一种免疫检查点，因其独特的表达特性和生物学功能，成为RIT药物的一个理想候选分子。本文从B7-H3的表达特点及其生物学功能等方面进行综述，并总结了以B7-H3为靶点的放射免疫治疗最新研究进展。

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²Institute for Interdisciplinary Drug Research and Translational Sciences, College of Pharmaceutical Sciences, Suzhou University, Suzhou 215123, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236709400992346137, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236700469687537974, authorId=1236709400749076488, language=CN, stringName=郑梦, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=¹苏州大学附属第一医院临床药理实验室，苏州 215006
²苏州大学药学院药物研究与转化交叉研究所，苏州 215123, bio={"content":"

郑梦，女，博士，研究方向：分子影像与临床药学。E-mail: 20204026016@stu.suda.edu.cn。

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郑梦，女，博士，研究方向：分子影像与临床药学。E-mail: 20204026016@stu.suda.edu.cn。

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