Article(id=1236700467942707429, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236700465119949418, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1666195200000, acceptedDateStr=2022-10-20, onlineDate=1772781968341, onlineDateStr=2026-03-06, pubDate=1681488000000, pubDateStr=2023-04-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772781968341, onlineIssueDateStr=2026-03-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772781968341, creator=13701087609, updateTime=1772781968341, updator=13701087609, issue=Issue{id=1236700465119949418, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='7', pageStart='657', pageEnd='760', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772781967668, creator=13701087609, updateTime=1772782901622, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236704382474047808, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236700465119949418, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236704382474047809, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236700465119949418, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=676, endPage=686, ext={EN=ArticleExt(id=1236700468152422634, articleId=1236700467942707429, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Progress in the clinical study of antidepressant drugs with different mechanisms, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

At present, the listed antidepressants have certain limitations, and the different mechanisms of which are closely related to their efficacy and safety. Therefore, the discovery of antidepressants with novel mechanisms is an important research direction in the field of antidepressants. This paper reviews some major antidepressants currently under clinical research stage, and analyzes their mechanisms of action, so as to provide reference for the development of antidepressants with new mechanisms of action.

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目前上市的治疗抑郁症（major depressive disorder, MDD）药物存在一定的局限性，其不同的作用机制与药效及安全性密切相关，因此发现新作用机制的抗抑郁药为目前MDD治疗领域的重要研究方向。本文综述了目前处于临床研究阶段的部分主要抗抑郁药物，分析其作用机制，为研发新作用机制的抗抑郁药物提供参考。

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王慧莹，女，硕士研究生，研究方向：抗抑郁候选药物体内分析及药动学。E-mail: whywxying@163.com。

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王慧莹，女，硕士研究生，研究方向：抗抑郁候选药物体内分析及药动学。E-mail: whywxying@163.com。

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