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Daridorexant is a dual orexin receptor antagonist (DORA), which was approved by the U.S. FDA on January 10, 2022 (trade name: Quviviq) for the treatment of adults with insomnia, characterized by diffculties with sleep onset and/or sleep maintenance. Unlike traditional sedative-hypnotic drugs, daridorexant inhibits the actions of the wake-promoting orexin neuropeptides, by specific binding to both orexin receptor．In this paper, the mechanism of action, pharmacodynamics, pharmacokinetics, safety, and clinical research of daridorexant are reviewed.

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daridorexant是一种双重食欲素受体拮抗剂（dual orexin receptor antagonist, DORA），于2022年1月10日被美国FDA批准上市（商品名：Quviviq），用于治疗以入睡困难和/或睡眠维持困难为特征的失眠症成人患者。与传统镇静类催眠药物不同，daridorexant通过与双重食欲素受体的特异性结合抑制觉醒食欲素神经肽的作用。本文对其作用机制、药效学、药动学、安全性及临床研究进行综述。

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⁴中国药科大学孟目的学院，南京 211198, bio={"content":"

王咏懿，女，本科，研究方向：基础药学。E-mail: 1760604026@qq.com。

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王咏懿，女，本科，研究方向：基础药学。E-mail: 1760604026@qq.com。

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