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2′,4′-dihydroxy-6′-methoxy-3′,5′-dimethylchalcone (DMC) is a natural product of chalcone type isolated from diverse plants with a variety of great pharmacological properties. This article reviews the research progress from physicochemical properties, sources, extraction and detection, chemical synthesis, and pharmacological activities, in order to provide a theoretical basis for the development or prodrug design of DMC.

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2′，4′-二羟基-6′-甲氧基-3′，5′-二甲基查耳酮（DMC）是一种来源于多种植物的查尔酮类天然产物，具有良好的药理活性。本文从理化性质、来源、提取与检测、化学合成、药理活性等方面对DMC的国内外研究进展进行综述，为DMC的前药设计和开发提供参考依据。

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李旭，男，硕士在读，研究方向：心血管药理学与新药研发。E-mail: 1961123364@qq.com。

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李旭，男，硕士在读，研究方向：心血管药理学与新药研发。E-mail: 1961123364@qq.com。

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