Article(id=1236696520536412892, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236696515473895464, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1650816000000, acceptedDateStr=2022-04-25, onlineDate=1772781027205, onlineDateStr=2026-03-06, pubDate=1673712000000, pubDateStr=2023-01-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772781027205, onlineIssueDateStr=2026-03-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772781027205, creator=13701087609, updateTime=1772781027205, updator=13701087609, issue=Issue{id=1236696515473895464, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='1', pageStart='1', pageEnd='109', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772781025999, creator=13701087609, updateTime=1772782685740, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236703476982542786, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236696515473895464, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236703476982542787, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236696515473895464, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=24, endPage=29, ext={EN=ArticleExt(id=1236696520817431276, articleId=1236696520536412892, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Research progress on hepatotoxicity of nanodrugs and nanoparticles, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Nanotechnology has greatly promoted the research and development of nanodrugs and nanoparticles, providing new therapeutic options for many diseases. However, due to their special physical and chemical properties and its easy accumulation in the liver, nanodrugs and nanoparticles can also bring potential hepatotoxicity risks to the body. This review summarizes the research progress of hepatotoxicity induced by nanodrugs or nanoparticles in recent years from the following three aspects: liver accumulation and cell-nanodrug interaction, toxic mechanisms and influencing factors of toxicity. Also, we discuss the limitations of the previous studies. This paper aims to provide new insights and references for the related researches on hepatotoxicity and preclinical safety evaluation of nanodrugs and nanoparticles.

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纳米技术的发展极大程度推动了纳米药物及纳米颗粒的研发，为多种疾病的治疗提供了新的用药选择。但由于其理化性质特殊且容易在肝脏产生蓄积，纳米药物和纳米颗粒也给机体带来了潜在的肝毒性风险。本文从肝脏蓄积与细胞-纳米药物相互作用、毒性作用机制以及影响因素3个方面对近年来纳米药物或纳米颗粒肝毒性的研究概况进行综述，并对既往研究存在的局限性进行了分析讨论，旨在为纳米药物及纳米颗粒肝毒性和临床前安全性评价相关研究提供新的思路与参考。

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²National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, Beijing Key Laboratory for Nonclinical Safety Evaluation of Drugs, Beijing 100176, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236703336339140992, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236696520536412892, authorId=1236703336112648557, language=CN, stringName=孙百阳, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=¹中国医学科学院北京协和医学院，北京 100730
²中国食品药品检定研究院国家药物安全评价监测中心，药物非临床安全评价研究北京市重点实验室，北京 100176, bio={"content":"

孙百阳，男，博士研究生，研究方向：药物临床前安全性评价。E-mail: bysun94@163.com。

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孙百阳，男，博士研究生，研究方向：药物临床前安全性评价。E-mail: bysun94@163.com。

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