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Glucagon-like peptide-1 (GLP-1) analogues have been widely used in the treatment of diabetes and obesity, and multi-receptor agonists that combine GLP-1 analogues with other intestinal hormones such as glucose-dependent insulin-stimulating peptide (GIP) and glucagon (GCG) are in clinical development. Compared with GLP-1 analogues, multi-receptor agonists can exert multiple physiological effects and have better effects in controlling blood glucose and reducing body weight with fewer side effects, which are expected to be a new therapy for diabetes and obesity. In this paper, we reviewed the development of intestinal hormone multi-receptor agonists, summarized their design ideas and clinical manifestations, and provided reference for the development of multi-receptor agonists.

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胰高血糖素样肽-1（glucagon-like peptide-1, GLP-1）类似物已广泛用于糖尿病和肥胖症的治疗，而将GLP-1类似物与其他肠道激素如葡萄糖依赖的促胰岛素肽、胰高血糖素结合的多受体激动剂正处于临床开发阶段。与GLP-1类似物相比，多受体激动剂可发挥多重生理效应、控制血糖和降低体重的效果更好、不良反应更小，有望成为糖尿病和肥胖症的新疗法。本文对在研的肠道激素类多受体激动剂进行综述，总结其设计思路及临床表现，为多受体激动剂类药物的开发提供参考。

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王媛，女，硕士研究生，研究方向：多肽与蛋白生物制剂。E-mail: wangyuancpu@163.com。

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