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2-anilinoquinoline is a characteristic structure of anticancer drugs, which can regulate various molecular targets related to tumor proliferation, differentiation, migration and apoptosis. Studies found that modifying the C-3, C-4, C-5 positions on the 2-anilinoquinoline ring and the aminobenzene ring to connect them with different groups, such as alkoxy, amide, carbonyl etc., can improve the targeting effect of drugs and enhance cytotoxicity. This review focuses on the structural modification and research progress of 2-anilinoquinoline derivatives as antitumor drugs in recent years to provide reference for future research.

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2-苯氨基喹啉是抗肿瘤药的特征结构，能够调控与肿瘤增殖、分化、迁移、凋亡有关的各种分子靶标。研究发现，对2-苯氨基喹啉环上C-3，C-4，C-5位以及氨基苯环进行修饰，将其与不同的基团连接，例如烷氧基、酰胺基、羰基等，可以提高药物的靶向性，增强抗肿瘤活性。本文重点介绍近年来2-苯氨基喹啉衍生物作为抗肿瘤类药物的结构修饰及研究进展，为之后的研究提供借鉴。

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李凤凤，女，硕士研究生，研究方向：新药的研究与开发。E-mail: 1974487569@qq.com。

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李凤凤，女，硕士研究生，研究方向：新药的研究与开发。E-mail: 1974487569@qq.com。

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