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Mobocertinib succinate is a novel and potent tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR). On September 15, 2021, it was approved by U.S. FDA for the first time, and the brand name is Exkivity. It is indicated for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with EGFR exon 20 insertion mutation, whose disease has progressed on or after platinum-based chemotherapy. This article introduces the drug's mechanism of action, pharmacokinetics, pharmacodynamics, clinical evaluation studies, and safety.

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琥珀酸莫博替尼是一种新型、强效的表皮生长因子受体（EGFR）酪氨酸激酶抑制剂。2021年9月15日，美国FDA首次批准琥珀酸莫博替尼上市（商品名：Exkivity），用于治疗携带EGFR 20外显子插入突变的局部晚期或转移性非小细胞肺癌成人患者，其疾病在铂类化疗期间或之后进展。本文对该药物的作用机制、药动学、药效学、临床研究评价、安全性等进行介绍。

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熊志翔，男，硕士研究生，研究方向：药物制剂新技术与新药研发。E-mail: 1523881732@qq.com。

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熊志翔，男，硕士研究生，研究方向：药物制剂新技术与新药研发。E-mail: 1523881732@qq.com。

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