Article(id=1236687126780236615, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236687122619495346, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1655568000000, acceptedDateStr=2022-06-19, onlineDate=1772778787559, onlineDateStr=2026-03-06, pubDate=1682784000000, pubDateStr=2023-04-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772778787559, onlineIssueDateStr=2026-03-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772778787559, creator=13701087609, updateTime=1772778787559, updator=13701087609, issue=Issue{id=1236687122619495346, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='8', pageStart='761', pageEnd='864', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772778786568, creator=13701087609, updateTime=1772779118928, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236688516713861515, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236687122619495346, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236688516713861516, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236687122619495346, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=799, endPage=805, ext={EN=ArticleExt(id=1236687128642507614, articleId=1236687126780236615, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Research progress in chemical composition, pharmacological effects, toxicology of Dictamni cortex and predictive analysis of its quality markers, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Dictamni cortex is the dried root bark of the Dictamnus L. in the Rutaceae family. It contains alkaloids, limonoids, phenylpropanoids, flavonoids, et al. Based on summarization of its chemical components, pharmacological effects and toxicity, and according to the concept of traditional Chinese medicine quality marker (Q-marker), the Q-markers of Dictamni cortex were predicted from the aspects of genetic relationship and measurability of components, traditional efficacy, traditional property, different producing areas and collecting periods, and component contents under different ultraviolet radiation intensities. γ-fagarine, limonin, dictamnine, obacunone and fraxinellone can be used as Q-markers of Dictamni cortex, which provide a scientific reference for the establishment of quality standards.

, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Xin-yue LIU, Le-le CHEN, Peng SUN, Zhao-shuang ZHAN, Jia-feng WANG), CN=ArticleExt(id=1236687128885777253, articleId=1236687126780236615, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=白鲜皮化学成分、药理作用和毒性研究进展及质量标志物预测分析, columnId=1236330553964810454, journalTitle=中国新药杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

白鲜皮为芸香科白鲜属植物白鲜(Dictamnus dasycarpus Turcz.)的干燥根皮,已发现含有生物碱类、柠檬苦素类、苯丙素类、黄酮类等成分。本文在对白鲜皮化学成分、药理作用和毒性进行综述的基础上,围绕中药质量标志物(Q-marker)概念,从植物亲缘学和成分可测性、传统药效、传统药性、产地和采收时期及不同紫外辐射强度下成分含量等方面对白鲜皮Q-marker成分进行预测分析,发现γ-崖椒碱、柠檬苦素、白鲜碱、黄柏酮和梣酮可作为白鲜皮Q-marker指标,以期为白鲜皮科学质量标准的建立提供参考。

, correspAuthors=null, authorNote=null, correspAuthorsNote=
展照双,女,硕士生导师,副教授,主要从事温病理论与临床研究。联系电话:(0531)89628527,E-mail:
王加锋,男,博士生导师,教授,主要从事中药药性理论与应用研究。联系电话:(0531)89628527,E-mail:
, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=cOn2edrhn/YnZFxRLAuc6Q==, magXml=0lIJBh/tisle6uggFispsA==, pdfUrl=null, pdf=zVGxZVmbv0HtarmJ2fQOKg==, pdfFileSize=5211220, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=LVvJfWHc9D3ob1OI71kXmQ==, mapNumber=null, authorCompany=null, fund=null, authors=

刘新月,女,硕士研究生,主要从事中药药性理论与应用研究。E-mail:

, authorsList=刘新月, 陈乐乐, 孙鹏, 展照双, 王加锋)}, authors=[Author(id=1236687468565688475, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=2460169059@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236687468662157469, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, authorId=1236687468565688475, language=EN, stringName=Xin-yue LIU, firstName=Xin-yue, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Shandong University of Traditional Chinese Medicine, Jinan 250355, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236687468741849246, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, authorId=1236687468565688475, language=CN, stringName=刘新月, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=山东中医药大学,济南 250355, bio={"content":"

刘新月,女,硕士研究生,主要从事中药药性理论与应用研究。E-mail:

"}, bioImg=null, bioContent=

刘新月,女,硕士研究生,主要从事中药药性理论与应用研究。E-mail:

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236687468481802391, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, xref=null, ext=[AuthorCompanyExt(id=1236687468490191000, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, companyId=1236687468481802391, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Shandong University of Traditional Chinese Medicine, Jinan 250355, China), AuthorCompanyExt(id=1236687468498579609, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, companyId=1236687468481802391, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=山东中医药大学,济南 250355)])]), Author(id=1236687468821541024, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236687469060616354, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, authorId=1236687468821541024, language=EN, stringName=Le-le CHEN, firstName=Le-le, middleName=null, lastName=CHEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Shandong University of Traditional Chinese Medicine, Jinan 250355, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236687469161279651, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, authorId=1236687468821541024, language=CN, stringName=陈乐乐, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=山东中医药大学,济南 250355, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236687468481802391, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, xref=null, ext=[AuthorCompanyExt(id=1236687468490191000, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, companyId=1236687468481802391, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Shandong University of Traditional Chinese Medicine, Jinan 250355, China), AuthorCompanyExt(id=1236687468498579609, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, companyId=1236687468481802391, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=山东中医药大学,济南 250355)])]), Author(id=1236687469228388517, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236687469312274599, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, authorId=1236687469228388517, language=EN, stringName=Peng SUN, firstName=Peng, middleName=null, lastName=SUN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Shandong University of Traditional Chinese Medicine, Jinan 250355, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236687469568127146, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, authorId=1236687469228388517, language=CN, stringName=孙鹏, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=山东中医药大学,济南 250355, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236687468481802391, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, xref=null, ext=[AuthorCompanyExt(id=1236687468490191000, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, companyId=1236687468481802391, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Shandong University of Traditional Chinese Medicine, Jinan 250355, China), AuthorCompanyExt(id=1236687468498579609, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, companyId=1236687468481802391, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=山东中医药大学,济南 250355)])]), Author(id=1236687471002579120, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=zzshuang2000@126.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236687471094853811, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, authorId=1236687471002579120, language=EN, stringName=Zhao-shuang ZHAN, firstName=Zhao-shuang, middleName=null, lastName=ZHAN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Shandong University of Traditional Chinese Medicine, Jinan 250355, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236687471182934201, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, authorId=1236687471002579120, language=CN, stringName=展照双, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=山东中医药大学,济南 250355, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236687468481802391, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, xref=null, ext=[AuthorCompanyExt(id=1236687468490191000, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, companyId=1236687468481802391, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Shandong University of Traditional Chinese Medicine, Jinan 250355, China), AuthorCompanyExt(id=1236687468498579609, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, companyId=1236687468481802391, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=山东中医药大学,济南 250355)])]), Author(id=1236687471333929149, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=wjfeng2000@126.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236687471438786755, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, authorId=1236687471333929149, language=EN, stringName=Jia-feng WANG, firstName=Jia-feng, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Shandong University of Traditional Chinese Medicine, Jinan 250355, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236687471510089927, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, authorId=1236687471333929149, language=CN, stringName=王加锋, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=山东中医药大学,济南 250355, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236687468481802391, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, xref=null, ext=[AuthorCompanyExt(id=1236687468490191000, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, companyId=1236687468481802391, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Shandong University of Traditional Chinese Medicine, Jinan 250355, China), AuthorCompanyExt(id=1236687468498579609, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, companyId=1236687468481802391, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=山东中医药大学,济南 250355)])])], keywords=[Keyword(id=1236687471694639310, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, language=EN, orderNo=1, keyword=Dictamni cortex), Keyword(id=1236687471753359571, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, language=EN, orderNo=2, keyword=chemical composition), Keyword(id=1236687471824662745, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, language=EN, orderNo=3, keyword=pharmacological effects), Keyword(id=1236687471933714655, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, language=EN, orderNo=4, keyword=quality marker), Keyword(id=1236687472038572265, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, language=EN, orderNo=5, keyword=predictive analysis), Keyword(id=1236687472151818479, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, language=CN, orderNo=1, keyword=白鲜皮), Keyword(id=1236687472252481783, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, language=CN, orderNo=2, keyword=化学成分), Keyword(id=1236687472378310913, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, language=CN, orderNo=3, keyword=药理作用), Keyword(id=1236687472541888783, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, language=CN, orderNo=4, keyword=质量标志物), Keyword(id=1236687472642552086, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, language=CN, orderNo=5, keyword=预测分析)], refs=null, funds=[Fund(id=1236687472856461598, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, awardId=null, language=CN, fundingSource=齐鲁医派中医学术流派传承项目(齐鲁道地药材炮制存性特色技术), fundOrder=null, country=null), Fund(id=1236687473007456547, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, awardId=null, language=CN, fundingSource=齐鲁医派中医学术流派传承项目(齐鲁温病流派通腑辨治热病中医药特色技术), fundOrder=null, country=null), Fund(id=1236687473137479974, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, awardId=SDYKC21047, language=CN, fundingSource=山东省研究生教育质量提升计划(SDYKC21047), fundOrder=null, country=null), Fund(id=1236687473326223657, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, awardId=2019-0042, language=CN, fundingSource=山东省中医药科技发展计划项目(2019-0042), fundOrder=null, country=null), Fund(id=1236687473460441393, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, awardId=2015-513, language=CN, fundingSource=山东省中医药科技发展计划项目(2015-513), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1236687468481802391, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, xref=null, ext=[AuthorCompanyExt(id=1236687468490191000, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, companyId=1236687468481802391, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Shandong University of Traditional Chinese Medicine, Jinan 250355, China), AuthorCompanyExt(id=1236687468498579609, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126780236615, companyId=1236687468481802391, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=山东中医药大学,济南 250355)])], figs=null, attaches=null, journal=Journal(id=1235980159023624194, delFlag=0, nameCn=中国新药杂志, nameEn=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, issn=1003-3734, eissn=null, cn=11-2850/R, coden=ZXZHA6, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of New Drugs, journalRemark=null, publicationField=null, createdTime=1772610233314, updatedTime=1772610649152, createdBy=18614031015, updatedBy=13701087609, firstLetterCn=C, firstLetterEn=C, subjectCode=Life Sciences, subjectName=null, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=ohPEEN//Vz1tDT3ZBNTp4Q==, picEn=f9WK9bvTM4guTmS/iGhOMg==, jcr=null, cjcr=null, exts=[JournalExt(id=1235981903275290962, language=CN, name=中国新药杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1772610649174, updatedTime=1772610649174, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1235981903338205523, language=EN, name=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1772610649189, updatedTime=1772610649189, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1235980733773295621, websiteList=[Website(id=1235982099191222761, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/CN, language=CN, createTime=1772610695884, createBy=18614031015, updateTime=1772610860397, updateBy=18614031015, name=中国新药杂志-中文, tplId=1146099689490845704, title=中国新药杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983918629966444, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=articleTextType, value=kx, createTime=1772611129672, updateTime=1772611129672, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918604800617, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=banner, value=null, createTime=1772611129666, updateTime=1772611129666, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918655132271, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=grayFlag, value=0, createTime=1772611129678, updateTime=1772611129678, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918596412008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611129664, updateTime=1772611129664, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918667715185, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=minRunFlag, value=0, createTime=1772611129681, updateTime=1772611129681, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918617383531, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic, createTime=1772611129669, updateTime=1772611129669, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918659326576, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=silenceFlag, value=0, createTime=1772611129679, updateTime=1772611129679, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918613189226, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1772611129668, updateTime=1772611129668, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918634160749, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeColor, value=null, createTime=1772611129673, updateTime=1772611129673, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918646743662, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeStyle, value=null, createTime=1772611129676, updateTime=1772611129676, creator=18614031015, updator=18614031015)]), Website(id=1235982099270914542, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/EN, language=EN, createTime=1772610695903, createBy=18614031015, updateTime=1772610875891, updateBy=18614031015, name=中国新药杂志-英文, tplId=1146101810881728533, title=Chinese Journal of New Drugs, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983955829248630, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=articleTextType, value=kx, createTime=1772611138541, updateTime=1772611138541, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955804082803, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=banner, value=null, createTime=1772611138535, updateTime=1772611138535, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955854414457, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=grayFlag, value=0, createTime=1772611138547, updateTime=1772611138547, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955795694194, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611138533, updateTime=1772611138533, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955866997371, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=minRunFlag, value=0, createTime=1772611138550, updateTime=1772611138550, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955820860021, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic, createTime=1772611138539, updateTime=1772611138539, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955862803066, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=silenceFlag, value=0, createTime=1772611138549, updateTime=1772611138549, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955812471412, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1772611138537, updateTime=1772611138537, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955837637239, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeColor, value=null, createTime=1772611138543, updateTime=1772611138543, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955846025848, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeStyle, value=null, createTime=1772611138545, updateTime=1772611138545, creator=18614031015, updator=18614031015)])], journalTitle=中国新药杂志, weixinUrl=null, journalUrl=http://www.newdrug.cn/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of New Drugs, journalPhotoCn=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPhotoEn=f9WK9bvTM4guTmS/iGhOMg==, journalFirstLetter=C, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/Y2023/V32/I8/799, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/Y2023/V32/I8/799, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/PDF/Y2023/V32/I8/799, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/PDF/Y2023/V32/I8/799, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, reference=null)
收藏切换
白鲜皮化学成分、药理作用和毒性研究进展及质量标志物预测分析
收藏切换
PDF下载
刘新月 , 陈乐乐 , 孙鹏 , 展照双 , 王加锋
中国新药杂志 | 综述 2023,32(8): 799-805
收起
收藏切换
中国新药杂志 | 综述 2023, 32(8): 799-805
白鲜皮化学成分、药理作用和毒性研究进展及质量标志物预测分析
全屏
刘新月 , 陈乐乐, 孙鹏, 展照双 , 王加锋
作者信息
  • 山东中医药大学,济南 250355
  • 刘新月,女,硕士研究生,主要从事中药药性理论与应用研究。E-mail:

通讯作者:

展照双,女,硕士生导师,副教授,主要从事温病理论与临床研究。联系电话:(0531)89628527,E-mail:
王加锋,男,博士生导师,教授,主要从事中药药性理论与应用研究。联系电话:(0531)89628527,E-mail:
Research progress in chemical composition, pharmacological effects, toxicology of Dictamni cortex and predictive analysis of its quality markers
Xin-yue LIU , Le-le CHEN, Peng SUN, Zhao-shuang ZHAN , Jia-feng WANG
Affiliations
  • Shandong University of Traditional Chinese Medicine, Jinan 250355, China
出版时间: 2023-04-30
文章导航
收藏切换

白鲜皮为芸香科白鲜属植物白鲜(Dictamnus dasycarpus Turcz.)的干燥根皮,已发现含有生物碱类、柠檬苦素类、苯丙素类、黄酮类等成分。本文在对白鲜皮化学成分、药理作用和毒性进行综述的基础上,围绕中药质量标志物(Q-marker)概念,从植物亲缘学和成分可测性、传统药效、传统药性、产地和采收时期及不同紫外辐射强度下成分含量等方面对白鲜皮Q-marker成分进行预测分析,发现γ-崖椒碱、柠檬苦素、白鲜碱、黄柏酮和梣酮可作为白鲜皮Q-marker指标,以期为白鲜皮科学质量标准的建立提供参考。

白鲜皮  /  化学成分  /  药理作用  /  质量标志物  /  预测分析

Dictamni cortex is the dried root bark of the Dictamnus L. in the Rutaceae family. It contains alkaloids, limonoids, phenylpropanoids, flavonoids, et al. Based on summarization of its chemical components, pharmacological effects and toxicity, and according to the concept of traditional Chinese medicine quality marker (Q-marker), the Q-markers of Dictamni cortex were predicted from the aspects of genetic relationship and measurability of components, traditional efficacy, traditional property, different producing areas and collecting periods, and component contents under different ultraviolet radiation intensities. γ-fagarine, limonin, dictamnine, obacunone and fraxinellone can be used as Q-markers of Dictamni cortex, which provide a scientific reference for the establishment of quality standards.

Dictamni cortex  /  chemical composition  /  pharmacological effects  /  quality marker  /  predictive analysis
刘新月, 陈乐乐, 孙鹏, 展照双, 王加锋. 白鲜皮化学成分、药理作用和毒性研究进展及质量标志物预测分析. 中国新药杂志, 2023 , 32 (8) : 799 -805 .
Xin-yue LIU, Le-le CHEN, Peng SUN, Zhao-shuang ZHAN, Jia-feng WANG. Research progress in chemical composition, pharmacological effects, toxicology of Dictamni cortex and predictive analysis of its quality markers[J]. Chinese Journal of New Drugs, 2023 , 32 (8) : 799 -805 .
  • 齐鲁医派中医学术流派传承项目(齐鲁道地药材炮制存性特色技术)
  • 齐鲁医派中医学术流派传承项目(齐鲁温病流派通腑辨治热病中医药特色技术)
  • 山东省研究生教育质量提升计划(SDYKC21047)
  • 山东省中医药科技发展计划项目(2019-0042)
  • 山东省中医药科技发展计划项目(2015-513)
2023年第32卷第8期
PDF下载
37
12
引用本文
BibTeX
文章信息
  • 首发时间:2026-03-06
  • 出版时间:2023-04-30
补充材料
相关文章
文章信息
作者
出版历史
  • 录用日期:2022-06-19
基金
齐鲁医派中医学术流派传承项目(齐鲁道地药材炮制存性特色技术)
齐鲁医派中医学术流派传承项目(齐鲁温病流派通腑辨治热病中医药特色技术)
山东省研究生教育质量提升计划(SDYKC21047)
山东省中医药科技发展计划项目(2019-0042)
山东省中医药科技发展计划项目(2015-513)
作者信息
    山东中医药大学,济南 250355

通讯作者:

展照双,女,硕士生导师,副教授,主要从事温病理论与临床研究。联系电话:(0531)89628527,E-mail:
王加锋,男,博士生导师,教授,主要从事中药药性理论与应用研究。联系电话:(0531)89628527,E-mail:
参考文献
分享链接
https://castjournals.cast.org.cn/joweb/zgxyzz/CN/1236687126780236615
分享至
全文二维码

扫描看全文

引用本文
BibTeX
本文的引用情况
2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏