Article(id=1236687126704747484, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236687122619495346, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1671552000000, acceptedDateStr=2022-12-21, onlineDate=1772778787541, onlineDateStr=2026-03-06, pubDate=1682784000000, pubDateStr=2023-04-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772778787541, onlineIssueDateStr=2026-03-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772778787541, creator=13701087609, updateTime=1772778787541, updator=13701087609, issue=Issue{id=1236687122619495346, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='8', pageStart='761', pageEnd='864', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772778786568, creator=13701087609, updateTime=1772779118928, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236688516713861515, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236687122619495346, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236688516713861516, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236687122619495346, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=835, endPage=839, ext={EN=ArticleExt(id=1236687129007419402, articleId=1236687126704747484, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Predictors of the clinical response to tofacitinib in rheumatoid arthritis, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To explore the predictors of the clinical response to tofacitinib in rheumatoid arthritis (RA).
Methods: The clinical data of a cohort of 256 RA patients regularly followed up at the Department of Rheumatology and Immunology, Peking University People's Hospital were analyzed, among whom 121 patients with DAS28-ESR≥3.2 were treated with tofacitinib. Data were collected from patients starting to receive tofacitinib and at 6-month follow-up to evaluate the remission rate and analyze the predictors for achieving Boolean 3v remission.
Results: Out of 121 patients treated with tofacitinib, 104 patients (86.0%) were treated with tofacitinib for more than 6 months and 17 patients changed medication within 6 months, including 10 patients (8.3%) due to poor efficacy and 7 patients (5.8%) for adverse effects. After 6 months of follow-up, the remission rates according to Boolean 3v, DAS28-ESR and CliDR were 72.8%, 57.0% and 44.7%, respectively. The EULAR response rate was 88.6%. Multivariable logistic regression analysis showed that gender, number of conventional synthetic DMARDs resistance and glucocorticoid combination were independent predictors for Boolean 3v remission after 6 months of tofacitinib treatment.
Conclusion: Female patients without glucocorticoids and a small number of conventional synthetic DMARDs resistance tend to get better response to tofacitinib.
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目的： 评价托法替布治疗类风湿关节炎（RA）的疗效预测因素。
方法： 回顾性分析在北京大学人民医院风湿免疫科规律随访的256例RA患者队列，其中基于ESR的28关节疾病活动度评分（DAS28-ESR）≥3.2并接受托法替布治疗的患者121例。收集患者开始接受托法替布治疗及6个月随访的临床资料，评价患者临床缓解率及欧洲抗风湿病联盟（EULAR）反应率，分析达到3变量-Boolean（Boolean-3v）缓解的预测因素。
结果： 121例托法替布治疗患者中，104例（86.0%）患者应用托法替布治疗6个月以上，17例在6个月内停药，其中因疗效不佳换药者10例（8.3%），因不良反应停药者7例（5.8%）。托法替布治疗6个月时，分别有72.8%，57.0%和44.7%患者达到Boolean-3v，DAS28-ESR及临床深度缓解（CliDR），EULAR反应率88.6%。多因素分析显示，女性、传统改善病情抗风湿药（DMARDs）抵抗数少以及不联合应用糖皮质激素是托法替布治疗6个月达到Boolean-3v缓解的独立预测因素。
结论： 女性、不联合糖皮质激素且传统DMARDs抵抗数少者应用托法替布更有助于疾病缓解。
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, authorsList=张立藩, 李敏, 孙兴, 李茹, 栗占国)}, authors=[Author(id=1236687473850503604, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126704747484, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=1810301243@pku.edu.cn, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236687473934389693, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236687126704747484, authorId=1236687473850503604, language=EN, stringName=Li-fan ZHANG, firstName=Li-fan, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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1北京大学人民医院风湿免疫科，北京 100044, bio={"content":"
张立藩，男，本科，主要从事自身免疫病发病机制及治疗研究。E-mail: 1810301243@pku.edu.cn。
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张立藩，男，本科，主要从事自身免疫病发病机制及治疗研究。E-mail: 1810301243@pku.edu.cn。
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