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Tumor immunotherapy is a major breakthrough in the history of tumor therapy. New immunooncological drugs targeting PD-1/PD-L1 and CAR-T cells have achieved gratifying clinical efficacy. However, due to the complexity and particularity of tumor immune microenvironment, it is difficult for a single target treatment mode to achieve a lasting response. Recurrence, metastasis and resistance are still difficult for most advanced cancer patients to overcome. Recently, PD-(L)1/TGF-β bispecific antibodies have become a hot spot in the research of tumor immunomodulatory drugs, which contains two functional domains and interacts with PD-(L)1 and TGF-β simultaneously to restore the activity of T cells and enhance the immune response. This paper mainly analyzes the clinical research progress of PD-(L)1/TGF-β bifunctional antibodies, which have been developing rapidly in recent years. We further analyze the existing problems and make an outlook on the prospect of dual-target tumor immunotherapy, in order to provide basis and reference for bifunctional or multifunctional drugs.

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肿瘤免疫疗法是肿瘤治疗发展史的一项重大突破，程序性死亡受体1/程序性死亡配体1（PD-1/PD-L1）和嵌合抗原受体T细胞（CAR-T）等免疫疗法取得了令人欣喜的临床疗效，但由于肿瘤免疫微环境的复杂性和特殊性，单一靶点的治疗模式难以达到持久的应答，复发转移和耐药仍是大多数晚期癌症患者难以克服的问题。近年来，PD-（L）1/转化生长因子-β（TGF-β）双特异性抗体成为肿瘤免疫调节药物研发的一大热点，其包含2个功能结构域，能够同时与PD-（L）1和TGF-β结合，使T细胞恢复活性，增强免疫应答。本文主要分析近年发展较快的PD-（L）1/TGF-β双功能抗体的临床研究进展，并分析目前存在的问题，对双靶点肿瘤免疫治疗的前景做出展望，以期为双功能甚至多功能药物的研发和临床应用提供依据和参考。

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植丽敏，女，硕士研究生，研究方向：新药研发。E-mail: 1158401697@qq.com。

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植丽敏，女，硕士研究生，研究方向：新药研发。E-mail: 1158401697@qq.com。

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