Article(id=1236678329110164007, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236678328279683421, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1665331200000, acceptedDateStr=2022-10-10, onlineDate=1772776690032, onlineDateStr=2026-03-06, pubDate=1686758400000, pubDateStr=2023-06-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772776690032, onlineIssueDateStr=2026-03-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772776690032, creator=13701087609, updateTime=1772776690032, updator=13701087609, issue=Issue{id=1236678328279683421, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='11', pageStart='1073', pageEnd='1176', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772776689834, creator=13701087609, updateTime=1772776816684, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236678860406837840, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236678328279683421, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236678860406837841, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236678328279683421, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1128, endPage=1131, ext={EN=ArticleExt(id=1236678330435564073, articleId=1236678329110164007, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=The effect of Wuzhi capsules on blood concentration and clinical efficacy of tacrolimus in patients with nephrotic syndrome: a literature analysis, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To analyze the effect of Wuzhi capsule on tacrolimus concentration and clinical efficacy.
Methods: The Chinese databases of Wanfang, CNKI and Weipu were searched to collect the relevant studies on the effect of Wuzhi capsule on the plasma concentration and clinical efficacy of tacrolimus in patients with nephrotic syndrome. The literatures that met the standards were included, and the effective data were extracted. SPSS 27.0 statistical software was applied for analysis.
Results: A total of 4 studies were included, and the statistical analysis results showed that Wuzhi capsule improved the plasma concentration of tacrolimus and standardized plasma concentration, and the difference was statistically significant (P<0.05). The 24-hour urine protein level in drug combination group was lower than that in single drug group, and the plasma albumin level was higher.
Conclusion: Wuzhi capsule can significantly improve the plasma concentration of tacrolimus and clinical efficacy in patients with nephrotic syndrome.
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目的： 分析五酯胶囊对他克莫司血药浓度及临床疗效的影响。
方法： 检索万方数据库、知网、维普中文数据库，收集五酯胶囊影响肾病综合征患者他克莫司血药浓度及临床疗效的相关研究，纳入符合标准的文献，提取有效数据，采用SPSS 27.0统计学软件进行分析，探索五酯胶囊对肾病综合征患者他克莫司血药浓度、临床疗效及安全性影响。
结果： 共纳入4篇文献，统计学分析结果显示五酯胶囊能提高他克莫司血药浓度及标准化血药浓度，差异具有统计学意义（P<0.05）。联合用药组24 h尿蛋白定量低于单独用药组，血浆白蛋白水平高于单独用药组。
结论： 五酯胶囊可显著提高肾病综合征患者他克莫司血药浓度及临床疗效。
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张春燕，女，硕士，主要从事临床药学、药动学等研究。E-mail: zhangchy66@163.com。
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张春燕，女，硕士，主要从事临床药学、药动学等研究。E-mail: zhangchy66@163.com。
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