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As the latest generation of sodium-glucose cotransporter-2 inhibitors (SGLT2i), ertugliflozin (ERT) has stable molecular structure, long half-life, significant hypoglycemic effect and good tolerance. It also has the protective effect of heart independent of its hypoglycemic activity. It is recommended as a priority treatment for the patients with type 2 diabetes mellitus (T₂DM) complicated with atherosclerotic cardiovascular disease (ASCVD) in China and abroad. In addition, ERT has a concrete effect on controlling the body weight of T₂DM patients, thus also has the value in the treatment of T₂DM patients with obesity. However, ERT is not recommended to be used in those T₂DM patients with renal insufficiency due to low safety profile.

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作为新一代钠-葡萄糖共转运体-2抑制剂，艾托格列净（ertugliflozin, ERT）分子结构更加稳定、半衰期更长、降糖效果显著、耐受性良好且具有独立于降糖作用的心血管保护作用，在国内外均被推荐用作治疗2型糖尿病（T₂DM）合并动脉粥样硬化性心血管疾病（ASCVD）的优先选择。此外，ERT对T₂DM患者的体重具有确切的控制效果，因此，ERT在T₂DM合并肥胖的患者中也具有一定使用价值。但在T₂DM合并肾功能不全患者中，ERT的安全性较低，不推荐使用。

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程钱，男，硕士，主管药师，研究方向：临床药学。E-mail: chengq_0713@163.com。

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程钱，男，硕士，主管药师，研究方向：临床药学。E-mail: chengq_0713@163.com。

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