Article(id=1236678328736862557, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236678328279683421, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1665072000000, acceptedDateStr=2022-10-07, onlineDate=1772776689942, onlineDateStr=2026-03-06, pubDate=1686758400000, pubDateStr=2023-06-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772776689942, onlineIssueDateStr=2026-03-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772776689942, creator=13701087609, updateTime=1772776689942, updator=13701087609, issue=Issue{id=1236678328279683421, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='11', pageStart='1073', pageEnd='1176', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772776689834, creator=13701087609, updateTime=1772776816684, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236678860406837840, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236678328279683421, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236678860406837841, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236678328279683421, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1163, endPage=1170, ext={EN=ArticleExt(id=1236678330297143647, articleId=1236678328736862557, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Preparation and evaluation of polymer micellar thermosensitive gel of Chinese medicinal chrysanthemum volatile oil, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To prepare and evaluate the polymer micellar thermosensitive gel of Chinese medicine chrysanthemum volatile oil.
Methods: The polymer micelles were prepared by the ethanol injection method, and the preparation process was optimized by orthogonal experiments. The morphology, particle size and zeta potential of the polymer micelles were evaluated. The thermosensitive gel was further prepared using poloxamer 407 and poloxamer 188 as the matrix. The rheological properties of the thermosensitive gel were measured by a flat plate rheometer, the irritability of the thermosensitive gel to rabbit eyes was investigated using Draize eye irritation score, and eye tissues were examined by pathological examination.
Results: The optimal preparation process of Chinese medicine chrysanthemum volatile oil polymer micelles thermosensitive gel was as follows: the concentration of chrysanthemum volatile oil was 15 μL·mL-1, the mass ratio of surfactant (TPGS∶phospholipid) was 3∶2, the concentration of surfactant was 37.5 mg·mL-1, and the mass ratio of phospholipids (HSPC∶DSPE-PEG2000) was 1∶1. The polymer micelles were closely arranged, spherical or quasi-spherical with the average particle size of (58.60±2.37) nm and zeta potential of (0.197±0.045) mV. The thermosensitive gel prepared with 21% mass fraction of poloxamer 407 and 3% mass fraction of poloxamer 188 was a pseudoplastic fluid with good rheological properties. The gel was basically non-irritating to rabbit eyes and had no irreversible tissue damage.
Conclusion: The prepared TCM chrysanthemum volatile oil polymer micelle thermosensitive gel has little irritation and good stability.
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目的： 制备中药菊花挥发油聚合物胶束温敏凝胶并进行评价。
方法： 采用乙醇注入法制备聚合物胶束，以正交实验优化制备工艺，对聚合物胶束形态特征、粒径和Zeta电位进行评价；以泊洛沙姆407和泊洛沙姆188为基质进一步制备温敏凝胶。采用平形板型流变仪对温敏凝胶的流变学性质进行测定；采用Draize眼部刺激评分考察温敏凝胶对家兔眼的刺激性，并对眼组织进行病理检查。
结果： 中药菊花挥发油聚合物胶束温敏凝胶最佳制备工艺为菊花挥发油浓度15 μL·mL-1，表面活性剂［聚乙二醇1000维生素E琥珀酸酯（TPGS）∶磷脂］质量比3∶2，表面活性剂的浓度为37.5 mg·mL-1，磷脂［高纯氢化大豆磷脂酰胆碱（HSPC）∶二硬脂酰基磷脂酰乙醇胺-聚乙二醇2000（DSPE-PEG2000）］质量比1∶1，该处方下聚合物胶束分子排列紧密，呈球形或类球形，平均粒径为（58.60±2.37） nm，Zeta电位为（0.197±0.045） mV。以21%质量分数的泊洛沙姆407和3%质量分数的泊洛沙姆188制得的温敏凝胶呈假塑性流体，具有良好的流变学性质。该凝胶对家兔眼基本无刺激且无不可逆性组织损伤。
结论： 制备的中药菊花挥发油聚合物胶束温敏凝胶刺激性小，稳定性好。
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1江西中医药大学 中药固体制剂制造技术国家工程研究中心，南昌 330004, bio={"content":"
万安平，女，硕士研究生，主要从事中药学研究。联系电话：(0791)87119661，E-mail: 2824511606@qq.cm。
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万安平，女，硕士研究生，主要从事中药学研究。联系电话：(0791)87119661，E-mail: 2824511606@qq.cm。
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1National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China
2Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236678332092305817, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236678328736862557, authorId=1236678331920339346, language=CN, stringName=何瑶, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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1江西中医药大学 中药固体制剂制造技术国家工程研究中心，南昌 330004
2江西中医药大学 现代中药制剂教育部重点实验室，南昌 330004, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236678330729156963, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236678328736862557, xref=1, ext=[AuthorCompanyExt(id=1236678330737545572, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236678328736862557, companyId=1236678330729156963, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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