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Objective: To explore the clinical characteristics and treatment strategies of central nervous system adverse events induced by atezolizumab to provide reference for recognition and treatment of such events.
Methods: Non-review articles on central nervous system adverse events caused by atezolizumab were screened, and relevant cases were summarized and analyzed. Furthermore, a case of anti-SOX1 paraneoplastic neurological encephalitis induced by atezolizumab in our hospital were discussed in combination with literature.
Results: Atezolizumab-induced central nervous system adverse reactions have been reported, but anti-SOX1 paraneoplastic neurological encephalitis was reported for the first time. Autoimmune antibody test had reference value for clinical diagnosis of this case. And simultaneous steroid pulse therapy and plasmapheresis were performed, leading to ideal clinical outcome.
Conclusion: The nervous system manifestation of patients using atezolizumab should be closely monitored pre and post treatment and clinicians should be alert to the occurrence of paraneoplastic encephalitis. The relevant autoantibodies should be systematically evaluated in times of need.
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目的： 探讨atezolizumab致中枢神经系统不良事件的临床特征及治疗策略，为临床识别及治疗提供参考。
方法： 检索Pubmed，Webscience，CNKI，Wanfang datebase等中英文数据库，筛选atezolizumab导致中枢神经系统不良事件的非综述性文章，并对相关病例总结分析，结合文献对我院收治的atezolizumab致小细胞肺癌患者SOX1抗体阳性副肿瘤性脑炎病例进行讨论。
结果： atezolizumab致中枢神经系统不良反应案例已有报道，但以SOX1抗体阳性为特征的副肿瘤性脑炎为首例。自身抗体检测对本例临床诊断具有参考价值，及时的大剂量激素冲击疗法和血浆置换使本例患者得到较好的临床结局。
结论： atezolizumab治疗前及治疗期间应密切监测患者的神经系统表现，警惕副肿瘤性脑炎的发生，必要时应对相关自身抗体进行系统性评估。
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李潇，女，医学博士，主管药师，主要研究方向为临床药学。联系电话：(010)88196338， E-mail: lixiao19881030@126.com。
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李潇，女，医学博士，主管药师，主要研究方向为临床药学。联系电话：(010)88196338， E-mail: lixiao19881030@126.com。
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