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Article(id=1236678240799093034, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236678235866583092, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1659888000000, acceptedDateStr=2022-08-08, onlineDate=1772776668977, onlineDateStr=2026-03-06, pubDate=1688054400000, pubDateStr=2023-06-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772776668977, onlineIssueDateStr=2026-03-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772776668977, creator=13701087609, updateTime=1772776668977, updator=13701087609, issue=Issue{id=1236678235866583092, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='12', pageStart='1177', pageEnd='1280', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772776667801, creator=13701087609, updateTime=1772776891082, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236679172442092503, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236678235866583092, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236679172442092504, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236678235866583092, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1220, endPage=1227, ext={EN=ArticleExt(id=1236678241033974070, articleId=1236678240799093034, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Research progress of calcium nanoparticles in tumor immunotherapy, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Tumor immunotherapy holds immense potential for tumor treatment because it can utilize the patient's immune system to eradicate tumors and prevent tumor recurrence. Nanoparticles are expected to be the optimal carrier for tumor immunotherapy due to their unique advantages. Ca2+, as the second messenger in cells, plays an important role in regulating the immune response in vivo. Recent studies have shown that calcium nanoparticles, such as calcium peroxide (CaO2) nanoparticles, calcium phosphate (CaP) nanoparticles, calcium hydride (CaH2) nanoparticles and calcium carbonate (CaCO3) nanoparticles, can activate anti-tumor immune responses through a variety of mechanisms. In addition, calcium nanoparticles can also be used in combination with other therapies such as photothermal therapy (PTT), sonodynamic therapy (SDT), chemotherapy and radiotherapy to synergically fight tumors to exert the "immune+" anti-tumor effect. In this article, we reviewed the recent research progress of calcium nanoparticles in tumor immunotherapy, and looked forward to the challenges of this field.

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肿瘤免疫治疗因其可以利用患者的免疫系统根除肿瘤并防止复发，而成为一种极具潜力的肿瘤治疗方法。纳米粒因其独特的优势，有望成为实现肿瘤免疫治疗的最佳载体。钙离子（calcium ion, Ca2+）作为细胞内的第二信使，在调节体内免疫反应中发挥着重要作用。近些年的研究表明，钙纳米粒如过氧化钙（calcium peroxide, CaO2）纳米粒、磷酸钙（calcium phosphate, CaP）纳米粒、氢化钙（calcium hydride, CaH2）纳米粒和碳酸钙（calcium carbonate, CaCO3）纳米粒等，可以通过多种机制激活抗肿瘤免疫反应。此外，钙纳米粒还可以通过与其他疗法如光热疗法（phototherapy, PTT）、声动力疗法（sonodynamic therapy, SDT）、化学治疗和放射疗法等的联合使用，协同对抗肿瘤，发挥出“免疫+”的抗肿瘤效果。本文总结了近几年钙纳米粒在肿瘤免疫治疗中取得的研究进展，并对其面临的挑战进行了展望。

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黄胜楠，女，博士，研究方向：中药新剂型与新技术研究。E-mail: 。
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直炜炜，女，硕士研究生，研究方向：中药新剂型与新技术研究。E-mail: 。

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直炜炜，女，硕士研究生，研究方向：中药新剂型与新技术研究。E-mail: 。

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钙纳米粒在肿瘤免疫治疗应用中的研究进展
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直炜炜 1 , 祝侠丽 1 , 贾永艳 1 , 胥芷灵 1 , 李一菁 1 , 黄胜楠 2, 3
中国新药杂志 | 综述 2023,32(12): 1220-1227
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中国新药杂志 | 综述 2023, 32(12): 1220-1227
钙纳米粒在肿瘤免疫治疗应用中的研究进展
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直炜炜1 , 祝侠丽1, 贾永艳1, 胥芷灵1, 李一菁1, 黄胜楠2, 3
作者信息
  • 1河南中医药大学药学院，郑州 450046
  • 2河南中医药大学中医药科学院，郑州 450046
  • 3郑州大学药学院，河南省肿瘤重大疾病靶向治疗和诊断重点实验室，郑州 450001

    • 直炜炜，女，硕士研究生，研究方向：中药新剂型与新技术研究。E-mail: 。

通讯作者:

黄胜楠，女，博士，研究方向：中药新剂型与新技术研究。E-mail: 。
Research progress of calcium nanoparticles in tumor immunotherapy
Wei-wei ZHI1 , Xia-li ZHU1, Yong-yan JIA1, Zhi-ling XU1, Yi-jing LI1, Sheng-nan HUANG2, 3
Affiliations
  • 1Pharmacy College, Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 2Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 3School of Pharmaceutical Sciences, Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases of Henan Province, Zhengzhou University, Zhengzhou 450001, China
出版时间: 2023-06-30
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摘要
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肿瘤免疫治疗因其可以利用患者的免疫系统根除肿瘤并防止复发，而成为一种极具潜力的肿瘤治疗方法。纳米粒因其独特的优势，有望成为实现肿瘤免疫治疗的最佳载体。钙离子（calcium ion, Ca2+）作为细胞内的第二信使，在调节体内免疫反应中发挥着重要作用。近些年的研究表明，钙纳米粒如过氧化钙（calcium peroxide, CaO2）纳米粒、磷酸钙（calcium phosphate, CaP）纳米粒、氢化钙（calcium hydride, CaH2）纳米粒和碳酸钙（calcium carbonate, CaCO3）纳米粒等，可以通过多种机制激活抗肿瘤免疫反应。此外，钙纳米粒还可以通过与其他疗法如光热疗法（phototherapy, PTT）、声动力疗法（sonodynamic therapy, SDT）、化学治疗和放射疗法等的联合使用，协同对抗肿瘤，发挥出“免疫+”的抗肿瘤效果。本文总结了近几年钙纳米粒在肿瘤免疫治疗中取得的研究进展，并对其面临的挑战进行了展望。

钙纳米粒  /  肿瘤免疫治疗  /  联合疗法  /  免疫+

Tumor immunotherapy holds immense potential for tumor treatment because it can utilize the patient's immune system to eradicate tumors and prevent tumor recurrence. Nanoparticles are expected to be the optimal carrier for tumor immunotherapy due to their unique advantages. Ca2+, as the second messenger in cells, plays an important role in regulating the immune response in vivo. Recent studies have shown that calcium nanoparticles, such as calcium peroxide (CaO2) nanoparticles, calcium phosphate (CaP) nanoparticles, calcium hydride (CaH2) nanoparticles and calcium carbonate (CaCO3) nanoparticles, can activate anti-tumor immune responses through a variety of mechanisms. In addition, calcium nanoparticles can also be used in combination with other therapies such as photothermal therapy (PTT), sonodynamic therapy (SDT), chemotherapy and radiotherapy to synergically fight tumors to exert the "immune+" anti-tumor effect. In this article, we reviewed the recent research progress of calcium nanoparticles in tumor immunotherapy, and looked forward to the challenges of this field.

calcium nanoparticles  /  tumor immunotherapy  /  combined therapy  /  immune+
直炜炜, 祝侠丽, 贾永艳, 胥芷灵, 李一菁, 黄胜楠. 钙纳米粒在肿瘤免疫治疗应用中的研究进展. 中国新药杂志, 2023 , 32 (12) : 1220 -1227 .
Wei-wei ZHI, Xia-li ZHU, Yong-yan JIA, Zhi-ling XU, Yi-jing LI, Sheng-nan HUANG. Research progress of calcium nanoparticles in tumor immunotherapy[J]. Chinese Journal of New Drugs, 2023 , 32 (12) : 1220 -1227 .
基金
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  • 国家自然科学基金项目(82003298)
  • 河南省博士后科研项目(201901025)
  • 河南省肿瘤重大疾病靶向治疗与诊断重点实验室开放基金项目(NMZL2020102)
  • 河南省科技攻关项目(232102310392)
  • 河南中医药大学科研创新项目(2022KYCX031)
2023年第32卷第12期
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  • 首发时间：2026-03-06
  • 出版时间：2023-06-30
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  • 录用日期：2022-08-08
基金
国家自然科学基金项目(82003298)
河南省博士后科研项目(201901025)
河南省肿瘤重大疾病靶向治疗与诊断重点实验室开放基金项目(NMZL2020102)
河南省科技攻关项目(232102310392)
河南中医药大学科研创新项目(2022KYCX031)
作者信息
    1河南中医药大学药学院，郑州 450046
    2河南中医药大学中医药科学院，郑州 450046
    3郑州大学药学院，河南省肿瘤重大疾病靶向治疗和诊断重点实验室，郑州 450001

通讯作者:

黄胜楠，女，博士，研究方向：中药新剂型与新技术研究。E-mail: 。
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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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