Article(id=1236678240631312534, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236678235866583092, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1665072000000, acceptedDateStr=2022-10-07, onlineDate=1772776668936, onlineDateStr=2026-03-06, pubDate=1688054400000, pubDateStr=2023-06-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772776668936, onlineIssueDateStr=2026-03-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772776668936, creator=13701087609, updateTime=1772776668936, updator=13701087609, issue=Issue{id=1236678235866583092, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='12', pageStart='1177', pageEnd='1280', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772776667801, creator=13701087609, updateTime=1772776891082, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236679172442092503, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236678235866583092, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236679172442092504, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236678235866583092, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1275, endPage=1280, ext={EN=ArticleExt(id=1236678240882970781, articleId=1236678240631312534, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Risperidone-associated venous thromboembolism in the treatment of schizophrenia: a case report and literature review, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To study venous thromboembolism associated with risperidone in the treatment of schizophrenia, so as to provide references for future clinical rational drug use.
Methods: A case of risperidone-associated pulmonary thromboembolism was presented and the cases of risperidone-associated venous thromboembolism, deep vein thrombosis and pulmonary thromboembolism were collected from Chinese VIP journal database, Wanfang and PubMed database and analyzed.
Results: A total of 13 cases were retrieved. Risperidone-induced venous thromboembolism has been reported in all age groups, and the dose ranged from 1 to 6 mg. Adverse reactions occurred within 2 months after the medication (10/13 cases), and the clinical manifestations were mainly respiratory symptoms or symptoms related to lower limb venous thromboembolism, such as lower limb edema and pain. Severe cases led to syncope, cardiopulmonary arrest or even death.
Conclusion: Clinicians and pharmacists should be familiarized with the characteristics of pulmonary thromboembolism associated with risperidone, weigh the advantages and disadvantages, and use it with caution. To reduce the occurrence of adverse reactions, coagulation function monitoring and venous ultrasound examination of lower limbs should be strengthened, and CT pulmonary angiography should be performed if necessary.
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目的： 探究抗精神病药物利培酮治疗精神分裂症相关的静脉血栓栓塞症的发生情况以及临床特点，为临床合理用药提供参考。
方法： 介绍临床药师参与的1例服用利培酮相关肺血栓栓塞症的严重不良反应病例，并以利培酮、静脉血栓栓塞症、深静脉血栓形成和肺血栓栓塞症为关键词，检索维普中文科技期刊数据库、万方数据库以及PubMed数据库等多个数据库收载的相关研究报道，并进行统计分析。
结果： 共检索到13例相关个案报道，利培酮导致的静脉血栓栓塞症从青年到老年都有报道，用药剂量1~6 mg，不良反应发生时间集中在用药后的2个月内（10/13例），临床主要表现为肺血栓栓塞以及下肢静脉血栓形成相关的呼吸系统症状和下肢水肿、疼痛，严重病例可致晕厥、心肺骤停乃至死亡。
结论： 临床医师、药师应了解利培酮相关患者肺血栓栓塞症的规律和特点，权衡利弊、谨慎使用，并加强凝血功能和下肢静脉超声检查，必要时完善CT肺动脉造影等检查，以减少不良反应的发生。
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1浙江大学医学院附属邵逸夫医院药学部，杭州 310016, bio={"content":"
吴圣洁，男，硕士研究生，主管药师，主要从事呼吸与危重症医学科临床药学工作。联系电话：(0571)87887507，E-mail: wushengjie@zju.edu.cn。
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吴圣洁，男，硕士研究生，主管药师，主要从事呼吸与危重症医学科临床药学工作。联系电话：(0571)87887507，E-mail: wushengjie@zju.edu.cn。
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