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Article(id=1236678238689349763, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236678235866583092, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1669305600000, acceptedDateStr=2022-11-25, onlineDate=1772776668474, onlineDateStr=2026-03-06, pubDate=1688054400000, pubDateStr=2023-06-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772776668474, onlineIssueDateStr=2026-03-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772776668474, creator=13701087609, updateTime=1772776668474, updator=13701087609, issue=Issue{id=1236678235866583092, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='12', pageStart='1177', pageEnd='1280', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772776667801, creator=13701087609, updateTime=1772776891082, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236679172442092503, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236678235866583092, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236679172442092504, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236678235866583092, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1243, endPage=1252, ext={EN=ArticleExt(id=1236678240350294158, articleId=1236678238689349763, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Prediction of potential quality markers of Aurantii fructus immaturus based on chemical pattern recognition and network pharmacology, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective:

To analyse and predict the potential quality markers of Aurantii fructus immaturus which based on HPLC fingerprint, chemical pattern recognition, the "Five Principles" of quality markers and network pharmacology.

Methods:

The fingerprint of Aurantii fructus immaturus was established by HPLC; OPLS-DA was used to screen the main difference components among the common peak groups; the "active ingredient-target-pathway" network of differential components was constructed by network pharmacology method to further support its rationality as potential quality makers (Q-Marker) of Aurantii fructus immaturus.

Results:

The fingerprints of 22 batches of Aurantii fructus immaturus were established, and 36 common peaks were identified. Two different components of naringin and neohesperidin were screened by OPLS-DA analysis. Network pharmacology confirmed that naringin and neohesperidin can be used as potential Q-Markers of Aurantii fructus immaturus.

Conclusion:

The established HPLC fingerprint method is stable and feasible, and the two differential components of naringin and neohesperidin screened can be used as potential Q-Markers of Aurantii fructus immaturus, which provided reference for the quality control and pharmacological mechanism research of Aurantii fructus immaturus.

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目的：

本文基于HPLC指纹图谱、化学模式识别、质量标志物“五原则”和网络药理学，分析预测枳实药材潜在质量标志物（Q-Marker）。

方法：

运用高效液相色谱法建立枳实指纹图谱；利用OPLS-DA筛选共有峰组间主要差异成分；利用网络药理学方法构建差异成分“活性成分-靶点-通路”网络，进一步佐证其作为枳实药材潜在Q-Marker的合理性。

结果：

建立了22批枳实药材指纹图谱，确认了36个共有峰；经OPLS-DA分析，筛选出柚皮苷和新橙皮苷2个差异成分；通过网络药理学佐证了柚皮苷和新橙皮苷可作为枳实药材潜在Q-Marker。

结论：

建立的HPLC指纹图谱方法稳定可行，筛选的柚皮苷和新橙皮苷2个差异成分可作为枳实潜在Q-Marker，为枳实药材质量控制和药效机制研究提供了参考。

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周日宝，男，博士，教授，主要从事中药资源与质量评价研究。联系电话：(0731)88458233，E-mail: 。
刘湘丹，女，博士，副教授，主要从事中药资源与质量评价研究。联系电话：(0731)88458233，E-mail: 。
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李灿，女，硕士生，主要从事中药资源与质量评价研究。联系电话：(0731)88458233，E-mail: 。

, authorsList=李灿, 曾娟, 龙雨青, 曾梅, 周新茹, 杨敏, 周伊昀, 周日宝, 刘湘丹)}, authors=[Author(id=1236678241411453114, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236678238689349763, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=1179819916@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236678241600196811, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236678238689349763, authorId=1236678241411453114, language=EN, stringName=Can LI, firstName=Can, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, 2, address=1School of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha 410208, China
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2湖南中医药大学 湘产大宗道地药材种质资源及规范化种植重点研究室，长沙 410208, bio={"content":"

李灿，女，硕士生，主要从事中药资源与质量评价研究。联系电话：(0731)88458233，E-mail: 。

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李灿，女，硕士生，主要从事中药资源与质量评价研究。联系电话：(0731)88458233，E-mail: 。

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基于化学模式识别和网络药理学预测枳实潜在质量标志物
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李灿 1, 2 , 曾娟 1, 2 , 龙雨青 1, 2 , 曾梅 1, 2 , 周新茹 1, 2 , 杨敏 1, 2 , 周伊昀 3 , 周日宝 1, 2, 4 , 刘湘丹 1, 2, 4
中国新药杂志 | 实验研究 2023,32(12): 1243-1252
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中国新药杂志 | 实验研究 2023, 32(12): 1243-1252
基于化学模式识别和网络药理学预测枳实潜在质量标志物
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李灿1, 2 , 曾娟1, 2, 龙雨青1, 2, 曾梅1, 2, 周新茹1, 2, 杨敏1, 2, 周伊昀3, 周日宝1, 2, 4 , 刘湘丹1, 2, 4
作者信息
  • 1湖南中医药大学 药学院，长沙 410208
  • 2湖南中医药大学 湘产大宗道地药材种质资源及规范化种植重点研究室，长沙 410208
  • 3湖南华夏湘众有限公司，安仁 423600
  • 4湖南中医药大学湖南省普通高等学校中药现代化研究重点实验室，长沙 410208

    • 李灿，女，硕士生，主要从事中药资源与质量评价研究。联系电话：(0731)88458233，E-mail: 。

通讯作者:

周日宝，男，博士，教授，主要从事中药资源与质量评价研究。联系电话：(0731)88458233，E-mail: 。
刘湘丹，女，博士，副教授，主要从事中药资源与质量评价研究。联系电话：(0731)88458233，E-mail: 。
Prediction of potential quality markers of Aurantii fructus immaturus based on chemical pattern recognition and network pharmacology
Can LI1, 2 , Juan ZENG1, 2, Yu-qing LONG1, 2, Mei ZENG1, 2, Xin-ru ZHOU1, 2, Min YANG1, 2, Yi-yun ZHOU3, Ri-bao ZHOU1, 2, 4 , Xiang-dan LIU1, 2, 4
Affiliations
  • 1School of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha 410208, China
  • 2Key Laboratory of Germplasm Resources and Standardized Planting of Bulk Authentic Medicinal Materials, Hunan University of Traditional Chinese Medicine, Changsha 410208, China
  • 3Hunan Huaxia Xiangzhong Co., Ltd., Anren 423600, China
  • 4Hunan Provincial Key Laboratory of Traditional Chinese Medicine Modernization Research in Colleges and Universities, Hunan University of Traditional Chinese Medicine, Changsha 410208, China
出版时间: 2023-06-30
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摘要
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目的：

本文基于HPLC指纹图谱、化学模式识别、质量标志物“五原则”和网络药理学，分析预测枳实药材潜在质量标志物（Q-Marker）。

方法：

运用高效液相色谱法建立枳实指纹图谱；利用OPLS-DA筛选共有峰组间主要差异成分；利用网络药理学方法构建差异成分“活性成分-靶点-通路”网络，进一步佐证其作为枳实药材潜在Q-Marker的合理性。

结果：

建立了22批枳实药材指纹图谱，确认了36个共有峰；经OPLS-DA分析，筛选出柚皮苷和新橙皮苷2个差异成分；通过网络药理学佐证了柚皮苷和新橙皮苷可作为枳实药材潜在Q-Marker。

结论：

建立的HPLC指纹图谱方法稳定可行，筛选的柚皮苷和新橙皮苷2个差异成分可作为枳实潜在Q-Marker，为枳实药材质量控制和药效机制研究提供了参考。

枳实  /  质量标志物  /  指纹图谱  /  OPLS-DA  /  网络药理学  /  柚皮苷  /  新橙皮苷
Objective:

To analyse and predict the potential quality markers of Aurantii fructus immaturus which based on HPLC fingerprint, chemical pattern recognition, the "Five Principles" of quality markers and network pharmacology.

Methods:

The fingerprint of Aurantii fructus immaturus was established by HPLC; OPLS-DA was used to screen the main difference components among the common peak groups; the "active ingredient-target-pathway" network of differential components was constructed by network pharmacology method to further support its rationality as potential quality makers (Q-Marker) of Aurantii fructus immaturus.

Results:

The fingerprints of 22 batches of Aurantii fructus immaturus were established, and 36 common peaks were identified. Two different components of naringin and neohesperidin were screened by OPLS-DA analysis. Network pharmacology confirmed that naringin and neohesperidin can be used as potential Q-Markers of Aurantii fructus immaturus.

Conclusion:

The established HPLC fingerprint method is stable and feasible, and the two differential components of naringin and neohesperidin screened can be used as potential Q-Markers of Aurantii fructus immaturus, which provided reference for the quality control and pharmacological mechanism research of Aurantii fructus immaturus.

Aurantii fructus immaturus  /  quality marker  /  fingerprint  /  OPLS-DA  /  network pharmacology  /  naringin  /  neohesperidin
李灿, 曾娟, 龙雨青, 曾梅, 周新茹, 杨敏, 周伊昀, 周日宝, 刘湘丹. 基于化学模式识别和网络药理学预测枳实潜在质量标志物. 中国新药杂志, 2023 , 32 (12) : 1243 -1252 .
Can LI, Juan ZENG, Yu-qing LONG, Mei ZENG, Xin-ru ZHOU, Min YANG, Yi-yun ZHOU, Ri-bao ZHOU, Xiang-dan LIU. Prediction of potential quality markers of Aurantii fructus immaturus based on chemical pattern recognition and network pharmacology[J]. Chinese Journal of New Drugs, 2023 , 32 (12) : 1243 -1252 .
基金
收起
  • 国家现代农业产业技术体系资助项目(CARS-21)
  • 湖南省现代农业产业技术体系项目
  • 湖南省科技厅中央引导地方项目(2020ZYQ045)
  • 湖南省教育厅重点研究项目(20A383)
  • 刘良院士工作站指导项目(21YS005)
  • 农业农村部农产品加工重点实验室 农业农村部农产品质量安全收贮运管控重点实验室开放课题(S2020KFKT-17)
  • 2020年湖南省一流专业建设点：中药资源与开发
  • 2020年湖南省一流专业建设点：中药资源与开发；湖南中医药大学中药学一流学科项目(校行科字【2018】3号)
2023年第32卷第12期
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  • 首发时间：2026-03-06
  • 出版时间：2023-06-30
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出版历史
  • 录用日期：2022-11-25
基金
国家现代农业产业技术体系资助项目(CARS-21)
湖南省现代农业产业技术体系项目
湖南省科技厅中央引导地方项目(2020ZYQ045)
湖南省教育厅重点研究项目(20A383)
刘良院士工作站指导项目(21YS005)
农业农村部农产品加工重点实验室 农业农村部农产品质量安全收贮运管控重点实验室开放课题(S2020KFKT-17)
2020年湖南省一流专业建设点：中药资源与开发
2020年湖南省一流专业建设点：中药资源与开发；湖南中医药大学中药学一流学科项目(校行科字【2018】3号)
作者信息
    1湖南中医药大学 药学院，长沙 410208
    2湖南中医药大学 湘产大宗道地药材种质资源及规范化种植重点研究室，长沙 410208
    3湖南华夏湘众有限公司，安仁 423600
    4湖南中医药大学湖南省普通高等学校中药现代化研究重点实验室，长沙 410208

通讯作者:

周日宝，男，博士，教授，主要从事中药资源与质量评价研究。联系电话：(0731)88458233，E-mail: 。
刘湘丹，女，博士，副教授，主要从事中药资源与质量评价研究。联系电话：(0731)88458233，E-mail: 。
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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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