Article(id=1236678238001492218, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236678235866583092, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1661270400000, acceptedDateStr=2022-08-24, onlineDate=1772776668310, onlineDateStr=2026-03-06, pubDate=1688054400000, pubDateStr=2023-06-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772776668310, onlineIssueDateStr=2026-03-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772776668310, creator=13701087609, updateTime=1772776668310, updator=13701087609, issue=Issue{id=1236678235866583092, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='12', pageStart='1177', pageEnd='1280', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772776667801, creator=13701087609, updateTime=1772776891082, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236679172442092503, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236678235866583092, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236679172442092504, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236678235866583092, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1191, endPage=1200, ext={EN=ArticleExt(id=1236678238295093501, articleId=1236678238001492218, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Evolutionary game simulation of tripartite strategy of delegated manufacturing of traditional Chinese medicine preparations in medical institution under MAH system, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To explore the elements that influence the behavior choices and the feasibility of delegated manufacturing of traditional Chinese medicine preparations in medical institutions under the marketing authorization holder (MAH) system.
Methods: A tripartite evolutionary game model of MAH, trustee, and government was built, the tripartite strategy choices in the process of entrusted manufacturing of preparations were analyzed, and simulation analysis was conducted to investigate the influencing factors of strategy choice.
Results: Considering the interest demand and the risk degree, keeping the appropriate subsidy and penalty intensity can help to improve the enthusiasm of MAH and trustee. The government's initiatives to boost rewards and penalties will help to improve MAH and client engagement in commission allocation, but too many rewards and penalties will conflict with the government's regulatory responsibilities. The social loss caused by the government's non-supervision urges the government to improve the supervision rate.
Conclusion: Entrusted manufacturing of traditional Chinese medicine preparations is feasible. Finding the point of profit balance among stakeholders helps to actualize the beneficial cycle of traditional Chinese medicine preparations in medical facilities.
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目的： 探究在药品上市许可持有人（MAH）制度下，医疗机构中药制剂委托配制时利益主体间的行为选择因素及委托配制行为的可行性。
方法： 本文构建了MAH推行、受托方受托、政府监管部门监管的三方演化博弈模型，分析了三方在制剂委托配制的过程中的策略选择，并结合仿真分析研究策略选择影响因素。
结果： 考虑利益需求与风险程度，保持适当的补贴与惩罚力度，有助于提高MAH和受托方的积极性；政府增强奖惩力度均有助于促进MAH和委托方积极参与委托配制，但过多的奖惩将不利于政府自身履行监管职责；政府不监管所造成的社会损失促使政府提高严格监管率。
结论： MAH制度背景下，医疗机构中药制剂委托配制行为具有可行性，各利益主体间找到利润均衡点，可促进医疗机构中药制剂的良性循环。
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严羽，女，硕士研究生，主要从事药事管理方向研究。E-mail: 1316752521@qq.com。
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严羽，女，硕士研究生，主要从事药事管理方向研究。E-mail: 1316752521@qq.com。
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