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Tuberculosis infection has always been a major concern for rheumatologists. The treatment of diseases such as spinal arthritis has entered the era of biologics, but the use of biologics will increase the risk of opportunistic infections such as tuberculosis. As a novel biological agent, secukinumab can improve the prognosis and quality of life of patients with ankylosing spondylitis and psoriasis by blocking the effect of IL-17A and playing an immunomodulatory function. This article reviews the safety of secukinumab in terms of tuberculosis infection in order to provide reference for clinical application.

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一直以来结核感染都是风湿科医师非常关注的问题，脊柱关节炎等疾病的治疗已经进入了生物制剂时代，而生物制剂的使用将会增加结核等机会感染的风险。司库奇尤单抗作为一种新型生物制剂，通过阻断白介素17A（IL-17A）作用，发挥免疫调节功能，用于治疗强直性脊柱炎、银屑病等效果理想，可改善患者预后、提高患者生活质量。本文就司库奇尤单抗在结核感染方面的安全性研究进行综述，以期为临床应用提供参考。

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宋晓燕，女，硕士研究生，主要从事风湿性疾病的临床研究工作。E-mail: songxiaoyan777@163.com。

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宋晓燕，女，硕士研究生，主要从事风湿性疾病的临床研究工作。E-mail: songxiaoyan777@163.com。

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