Article(id=1236408360929652908, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236408356815032449, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1652112000000, acceptedDateStr=2022-05-10, onlineDate=1772712324601, onlineDateStr=2026-03-05, pubDate=1676390400000, pubDateStr=2023-02-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772712324601, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772712324601, creator=13701087609, updateTime=1772712324601, updator=13701087609, issue=Issue{id=1236408356815032449, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='3', pageStart='217', pageEnd='328', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1772712323621, creator=13701087609, updateTime=1772712475250, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236408992868659518, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236408356815032449, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236408992868659519, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236408356815032449, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=276, endPage=282, ext={EN=ArticleExt(id=1236408361156145344, articleId=1236408360929652908, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Protective effect of baicalein on mice with ulcerative colitis induced by dextran sulfate sodium salt, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: to investigate the therapeutic effect and possible mechanism of baicalein on ulcerative colitis induced by dextran sulfate sodium salt (DSS) in mice.
Methods: A total of 42 male BALB/c mice were randomly divided into 6 groups (n=7), including control group, model group, baicalein groups (low-dose, medium-dose and high-dose) and mesalazine group (positive). The UC model of mice was established by 4% DSS. After the model was successfully established, the control group and the model group were given distilled water ad libitum, baicalein suspension of 10, 20, and 40 mg·kg-1, and the positive drug mesalazine 600 mg·kg-1, ig, for 14 days. The disease activity index (DAI) was calculated and evaluated, the changes of colon histopathology were observed by hematoxylin-eosin (HE) staining, and the levels of lipopolysaccharide (LPS) and secretory immunoglobulin A (sIg A) in serum were measured by ELISA. The expression levels of interleukin-6 (IL-6), tumor necrosis factor α (TNF-α) and nuclear factor of activated B(NF-κB) were detected by Western blotting.
Results: Baicalein decreased DAI index of UC mice, decreased the protein expressions of IL-6, TNF-α and NF-κB in colon tissue, decreased the serum levels of LPS, and increased the content of sIg A in serum.
Conclusion: Baicalein reduced the inflammatory response and enhanced the immunity of UC mice, and the mechanism is related to regulating the expression of NF-κB in colon.
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目的： 探究黄芩素（baicalein）对葡聚糖硫酸钠（dextran sulfate sodium salt, DSS）诱导的溃疡性结肠炎（ulcerative colitis, UC）小鼠的疗效及可能的作用机制。
方法： 将42只雄性BALB/c小鼠随机分为6组（n=7），分别为空白组，模型组，黄芩素低、中、高剂量组和美沙拉嗪阳性药物对照组。采用4%的DSS创建小鼠UC模型，造模成功后，空白组和模型组自由饮用蒸馏水，黄芩素低、中、高剂量组分别灌胃（ig）10，20，40 mg·kg-1黄芩素混悬液，阳性药物组给予美沙拉嗪600 mg·kg-1，ig，连续治疗14 d。计算并评价疾病活动指数（DAI）；采用苏木精-伊红染色法（HE）观察小鼠结肠组织病理学变化；采用酶联免疫吸附测定（ELISA）试剂盒定量检测血清中脂多糖（LPS）、分泌型免疫球蛋白A（sIg A）水平；采用蛋白免疫印迹法（Western blot）检测各组小鼠结肠组织中白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）和核转录因子-κB（NF-κB）的表达。
结果： 黄芩素可降低UC小鼠DAI指数，降低结肠组织中IL-6，TNF-α，NF-κB蛋白表达，降低血清中LPS水平，提高血清中sIg A的含量。
结论： 黄芩素可通过降低炎性反应、增强机体免疫，对UC小鼠发挥疗效，其作用机制与调节结肠NF-κB的表达有关。
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成宁宁，女，硕士研究生，主要从事天然药物活性成分筛选及提取、分离、结构研究。E-mail: 1336962635@qq.com。
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成宁宁，女，硕士研究生，主要从事天然药物活性成分筛选及提取、分离、结构研究。E-mail: 1336962635@qq.com。
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