Article(id=1236408360099180662, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236408356815032449, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1647187200000, acceptedDateStr=2022-03-14, onlineDate=1772712324404, onlineDateStr=2026-03-05, pubDate=1676390400000, pubDateStr=2023-02-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772712324404, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772712324404, creator=13701087609, updateTime=1772712324404, updator=13701087609, issue=Issue{id=1236408356815032449, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='3', pageStart='217', pageEnd='328', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1772712323621, creator=13701087609, updateTime=1772712475250, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236408992868659518, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236408356815032449, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236408992868659519, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236408356815032449, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=323, endPage=328, ext={EN=ArticleExt(id=1236408360329867399, articleId=1236408360099180662, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Literature survey of perampanel-related treatment emergent adverse events, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To analyze the characteristics of perampanel-related treatment emergent adverse events (TEAEs), providing references for clinical rational drug use.
Methods: The literatures about TEAEs caused by perampanel were retrieved from databases like CNKI, Wanfang, VIP, PubMed, ScienceDirect and Web of Science. The cases were divided into treatment group and overdose group according to the drug dose.
Results: A total of 20 literatures including 25 cases were reported, with 14 cases in the treatment group and 11 cases in the overdose group. Most TEAEs occurred within 60 days after drug administration in the treatment group (8 cases, 32.00%), mainly involving TEAEs in mental system (7 cases, 28.00%) and nervous system (3 cases, 12.00%). The TEAEs occurred in the treatment group were relieved after withdrawal and/or symptomatic treatment. All TEAEs mainly occurred in nervous system (9 cases, 36.00%) and the mental system (5 cases, 20.00%) on the day of medication in the overdose group, among which 9 cases were completely improved, and 2 cases had sequelae after treatment.
Conclusion: TEAEs caused by perampanel should be paid attention to, and medication education should be strengthened to avoid the occurrence of serious TEAEs and ensure the safety of clinical medication.
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目的: 分析吡仑帕奈(perampanel, PER)导致的治疗相关不良事件(treatment emergent adverse events, TEAEs)特点,为临床合理用药提供参考。
方法: 检索中国知网、万方、维普数据库、PubMed、ScienceDirect和Web of Science数据库中公开发表的PER致 TEAE个案并进行分析,根据用药剂量分为治疗组和过量组。
结果: 收集个案报道20篇共25例,其中治疗组14例,过量组11例。治疗组TEAE多发生在用药后60 d内(8例,32.00%),主要累及精神系统(7例,28.00%)和神经系统(3例,12.00%);经停药及/或对症处理后均好转。过量组患者TEAE均发生在用药当天,主要累及神经系统(9例,36.00%)和精神系统(5例,20.00%),经治疗后9例痊愈,2例留有后遗症。
结论: 应关注PER所致TEAE,加强用药教育,避免严重TEAE发生,保证用药安全。
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丁玲,女,主任医师,研究方向:癫痫。联系电话:(0731)89668308,E-mail: ling-ding@cssdsyy.com。
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