Article(id=1236408360099180662, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236408356815032449, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1647187200000, acceptedDateStr=2022-03-14, onlineDate=1772712324404, onlineDateStr=2026-03-05, pubDate=1676390400000, pubDateStr=2023-02-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772712324404, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772712324404, creator=13701087609, updateTime=1772712324404, updator=13701087609, issue=Issue{id=1236408356815032449, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='3', pageStart='217', pageEnd='328', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1772712323621, creator=13701087609, updateTime=1772712475250, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236408992868659518, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236408356815032449, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236408992868659519, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236408356815032449, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=323, endPage=328, ext={EN=ArticleExt(id=1236408360329867399, articleId=1236408360099180662, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Literature survey of perampanel-related treatment emergent adverse events, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective:

To analyze the characteristics of perampanel-related treatment emergent adverse events (TEAEs), providing references for clinical rational drug use.

Methods:

The literatures about TEAEs caused by perampanel were retrieved from databases like CNKI, Wanfang, VIP, PubMed, ScienceDirect and Web of Science. The cases were divided into treatment group and overdose group according to the drug dose.

Results:

A total of 20 literatures including 25 cases were reported, with 14 cases in the treatment group and 11 cases in the overdose group. Most TEAEs occurred within 60 days after drug administration in the treatment group (8 cases, 32.00%), mainly involving TEAEs in mental system (7 cases, 28.00%) and nervous system (3 cases, 12.00%). The TEAEs occurred in the treatment group were relieved after withdrawal and/or symptomatic treatment. All TEAEs mainly occurred in nervous system (9 cases, 36.00%) and the mental system (5 cases, 20.00%) on the day of medication in the overdose group, among which 9 cases were completely improved, and 2 cases had sequelae after treatment.

Conclusion:

TEAEs caused by perampanel should be paid attention to, and medication education should be strengthened to avoid the occurrence of serious TEAEs and ensure the safety of clinical medication.

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目的:

分析吡仑帕奈(perampanel, PER)导致的治疗相关不良事件(treatment emergent adverse events, TEAEs)特点,为临床合理用药提供参考。

方法:

检索中国知网、万方、维普数据库、PubMed、ScienceDirect和Web of Science数据库中公开发表的PER致 TEAE个案并进行分析,根据用药剂量分为治疗组和过量组。

结果:

收集个案报道20篇共25例,其中治疗组14例,过量组11例。治疗组TEAE多发生在用药后60 d内(8例,32.00%),主要累及精神系统(7例,28.00%)和神经系统(3例,12.00%);经停药及/或对症处理后均好转。过量组患者TEAE均发生在用药当天,主要累及神经系统(9例,36.00%)和精神系统(5例,20.00%),经治疗后9例痊愈,2例留有后遗症。

结论:

应关注PER所致TEAE,加强用药教育,避免严重TEAE发生,保证用药安全。

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刘丽华,女,主任药师,研究方向:临床药学。联系电话:(0731)85171337,E-mail:
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丁玲,女,主任医师,研究方向:癫痫。联系电话:(0731)89668308,E-mail:

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吡仑帕奈不良事件文献分析
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丁玲 1 , 刘丽华 2 , 罗星 1 , 黄芳 1 , 汤显靖 1 , 毕方方 3
中国新药杂志 | 药物安全与合理应用 2023,32(3): 323-328
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中国新药杂志 | 药物安全与合理应用 2023, 32(3): 323-328
吡仑帕奈不良事件文献分析
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丁玲1 , 刘丽华2 , 罗星1, 黄芳1, 汤显靖1, 毕方方3
作者信息
  • 1长沙市第三医院神经内科/长沙市血管病防治研究所,长沙 410015
  • 2长沙市第三医院药学部,长沙 410015
  • 3中南大学湘雅医院神经内科,长沙 410008
  • 丁玲,女,主任医师,研究方向:癫痫。联系电话:(0731)89668308,E-mail:

通讯作者:

刘丽华,女,主任药师,研究方向:临床药学。联系电话:(0731)85171337,E-mail:
Literature survey of perampanel-related treatment emergent adverse events
Ling DING1 , Li-hua LIU2 , Xing LUO1, Fang HUANG1, Xian-jing TANG1, Fang-fang BI3
Affiliations
  • 1Department of Neurology, The Third Hospital of Changsha, Vascular Disease Control And Prevention Institute of Changsha, Changsha 410015, China
  • 2Department of Pharmacy, The Third Hospital of Changsha, Changsha 410015, China
  • 3Department of Neurology, Xiangya Hospital Central South University, Changsha 410008, China
出版时间: 2023-02-15
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目的:

分析吡仑帕奈(perampanel, PER)导致的治疗相关不良事件(treatment emergent adverse events, TEAEs)特点,为临床合理用药提供参考。

方法:

检索中国知网、万方、维普数据库、PubMed、ScienceDirect和Web of Science数据库中公开发表的PER致 TEAE个案并进行分析,根据用药剂量分为治疗组和过量组。

结果:

收集个案报道20篇共25例,其中治疗组14例,过量组11例。治疗组TEAE多发生在用药后60 d内(8例,32.00%),主要累及精神系统(7例,28.00%)和神经系统(3例,12.00%);经停药及/或对症处理后均好转。过量组患者TEAE均发生在用药当天,主要累及神经系统(9例,36.00%)和精神系统(5例,20.00%),经治疗后9例痊愈,2例留有后遗症。

结论:

应关注PER所致TEAE,加强用药教育,避免严重TEAE发生,保证用药安全。

吡仑帕奈  /  治疗相关不良事件  /  文献分析
Objective:

To analyze the characteristics of perampanel-related treatment emergent adverse events (TEAEs), providing references for clinical rational drug use.

Methods:

The literatures about TEAEs caused by perampanel were retrieved from databases like CNKI, Wanfang, VIP, PubMed, ScienceDirect and Web of Science. The cases were divided into treatment group and overdose group according to the drug dose.

Results:

A total of 20 literatures including 25 cases were reported, with 14 cases in the treatment group and 11 cases in the overdose group. Most TEAEs occurred within 60 days after drug administration in the treatment group (8 cases, 32.00%), mainly involving TEAEs in mental system (7 cases, 28.00%) and nervous system (3 cases, 12.00%). The TEAEs occurred in the treatment group were relieved after withdrawal and/or symptomatic treatment. All TEAEs mainly occurred in nervous system (9 cases, 36.00%) and the mental system (5 cases, 20.00%) on the day of medication in the overdose group, among which 9 cases were completely improved, and 2 cases had sequelae after treatment.

Conclusion:

TEAEs caused by perampanel should be paid attention to, and medication education should be strengthened to avoid the occurrence of serious TEAEs and ensure the safety of clinical medication.

perampanel  /  treatment emergent adverse events  /  literature analysis
丁玲, 刘丽华, 罗星, 黄芳, 汤显靖, 毕方方. 吡仑帕奈不良事件文献分析. 中国新药杂志, 2023 , 32 (3) : 323 -328 .
Ling DING, Li-hua LIU, Xing LUO, Fang HUANG, Xian-jing TANG, Fang-fang BI. Literature survey of perampanel-related treatment emergent adverse events[J]. Chinese Journal of New Drugs, 2023 , 32 (3) : 323 -328 .
  • 国家重点研发计划癫痫临床队列研究项目(2017YFC0907702)
2023年第32卷第3期
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  • 首发时间:2026-03-05
  • 出版时间:2023-02-15
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  • 录用日期:2022-03-14
基金
国家重点研发计划癫痫临床队列研究项目(2017YFC0907702)
作者信息
    1长沙市第三医院神经内科/长沙市血管病防治研究所,长沙 410015
    2长沙市第三医院药学部,长沙 410015
    3中南大学湘雅医院神经内科,长沙 410008

通讯作者:

刘丽华,女,主任药师,研究方向:临床药学。联系电话:(0731)85171337,E-mail:
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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