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Abrocitinib is a selective small-molecule Janus kinase-1 inhibitor. It was approved by the U.S. FDA for the treatment of adults with refractory, moderate-to-severe atopic dermatitis on January 14, 2022. It is the third oral JAK inhibitors for atopic dermatitis in the world, slightly later than baricitinib and upadacitinib developed by Incyte and AbbVie, respectively. Although the U.S. FDA label contains a black box warning against JAK inhibitors, safety data from clinical trials reveal a manageable tolerability and longer-term safety. This paper introduces the mechanism of action, dosage and administration, pharmacokinetics, clinical studies and safety evaluation of the drug.

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abrocitinib是一种选择性小分子Janus激酶（JAK）1抑制剂，于2022年1月14日经美国FDA批准上市，用于难治性、中重度特应性皮炎成人患者。它是全球第三款获准治疗特应性皮炎的口服JAK抑制剂，略晚于因塞特公司开发的baricitinib以及艾伯维公司开发的upadacitinib。虽然美国FDA药品标签中包含了一个针对JAK抑制剂的黑框警告，但临床试验表明，abrocitinib具有可控的耐受性和长期安全性。本文对该药物的作用机制、用法用量、药动学、临床研究、安全性评价等进行介绍。

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周映红，女，硕士，馆员，主要从事药物情报管理与分析。联系电话：(021)51322614，E-mail: zhouyh@shutcm.edu.cn。

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周映红，女，硕士，馆员，主要从事药物情报管理与分析。联系电话：(021)51322614，E-mail: zhouyh@shutcm.edu.cn。

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