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Article(id=1236408357599367297, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236408356815032449, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1655481600000, acceptedDateStr=2022-06-18, onlineDate=1772712323807, onlineDateStr=2026-03-05, pubDate=1676390400000, pubDateStr=2023-02-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772712323807, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772712323807, creator=13701087609, updateTime=1772712323807, updator=13701087609, issue=Issue{id=1236408356815032449, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='3', pageStart='217', pageEnd='328', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1772712323621, creator=13701087609, updateTime=1772712475250, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236408992868659518, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236408356815032449, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236408992868659519, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236408356815032449, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=217, endPage=223, ext={EN=ArticleExt(id=1236408357897162885, articleId=1236408357599367297, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Analysis of the global pipeline and development trend of antidepressants, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

There are many unmet clinical needs of antidepressants, such as slow onset of action and low remission rate. The high degree of difficulty in its research and development is related to the high cost of research and the limitations of current understanding of the pathogenesis of major depressive disorder. To facilitate pharmaceutical research and development practitioners and to keep abreast of the frontiers of antidepressant research and expand research ideas, this paper summarizes the clinical research status and pipeline analysis of antidepressants, and sorts out the current global antidepressant clinical research trends and clinical research direction of antidepressants in China.

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现有抗抑郁药起效慢、治愈率低，有诸多未满足的临床需求，其研发难度与居高不下的研发成本及当前对于抑郁症发病机制认识的局限性有关。为方便药物研发者及时了解抗抑郁药研发前沿、拓展研究思路，本文综述了抗抑郁药的临床研发现状及管线分析，梳理了当前全球抗抑郁药临床研发趋势及我国抗抑郁药临床研发的发展方向。

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李华芳，女，博士生导师，教授，主要从事精神药理学研究。联系电话：(021)34773107，E-mail: 。
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共同第一作者

罗澜，女，博士研究生，研究方向：精神病与精神卫生学。联系电话：(021)34773107，E-mail: 。

石真玉，女，临床规划分析师，研究方向：药物临床研发策略。联系电话：(021)24228888，E-mail: 。

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罗澜，女，博士研究生，研究方向：精神病与精神卫生学。联系电话：(021)34773107，E-mail: 。

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罗澜，女，博士研究生，研究方向：精神病与精神卫生学。联系电话：(021)34773107，E-mail: 。

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石真玉，女，临床规划分析师，研究方向：药物临床研发策略。联系电话：(021)24228888，E-mail: 。

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石真玉，女，临床规划分析师，研究方向：药物临床研发策略。联系电话：(021)24228888，E-mail: 。

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抗抑郁药的全球管线和研发趋势分析
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罗澜 1 , 石真玉 2 , 赖水琴 2 , 吴维娟 2 , 魏宇梅 1 , 沈一峰 1 , 李华芳 1
中国新药杂志 | 新药述评与论坛 2023,32(3): 217-223
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中国新药杂志 | 新药述评与论坛 2023, 32(3): 217-223
抗抑郁药的全球管线和研发趋势分析
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罗澜1 , 石真玉2 , 赖水琴2, 吴维娟2, 魏宇梅1, 沈一峰1, 李华芳1
作者信息
  • 1上海交通大学医学院附属精神卫生中心，上海 200030
  • 2艾昆纬医药科技（上海）有限公司临床运营卓越中心， 上海 200032

    • 罗澜，女，博士研究生，研究方向：精神病与精神卫生学。联系电话：(021)34773107，E-mail: 。

    石真玉，女，临床规划分析师，研究方向：药物临床研发策略。联系电话：(021)24228888，E-mail: 。

通讯作者:

李华芳，女，博士生导师，教授，主要从事精神药理学研究。联系电话：(021)34773107，E-mail: 。
Analysis of the global pipeline and development trend of antidepressants
Lan LUO1 , Zhen-yu SHI2 , Shui-qin LAI2, Wei-juan WU2, Yu-mei WEI1, Yi-feng SHEN1, Hua-fang LI1
Affiliations
  • 1Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China
  • 2Center of Clinical Operations Excellence (CCOE), IQVIA RDS (Shanghai) Co., Ltd., Shanghai 200032, China
出版时间: 2023-02-15
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摘要
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现有抗抑郁药起效慢、治愈率低，有诸多未满足的临床需求，其研发难度与居高不下的研发成本及当前对于抑郁症发病机制认识的局限性有关。为方便药物研发者及时了解抗抑郁药研发前沿、拓展研究思路，本文综述了抗抑郁药的临床研发现状及管线分析，梳理了当前全球抗抑郁药临床研发趋势及我国抗抑郁药临床研发的发展方向。

抑郁症  /  抗抑郁药  /  临床研发

There are many unmet clinical needs of antidepressants, such as slow onset of action and low remission rate. The high degree of difficulty in its research and development is related to the high cost of research and the limitations of current understanding of the pathogenesis of major depressive disorder. To facilitate pharmaceutical research and development practitioners and to keep abreast of the frontiers of antidepressant research and expand research ideas, this paper summarizes the clinical research status and pipeline analysis of antidepressants, and sorts out the current global antidepressant clinical research trends and clinical research direction of antidepressants in China.

depression  /  antidepressant  /  drug development
罗澜, 石真玉, 赖水琴, 吴维娟, 魏宇梅, 沈一峰, 李华芳. 抗抑郁药的全球管线和研发趋势分析. 中国新药杂志, 2023 , 32 (3) : 217 -223 .
Lan LUO, Zhen-yu SHI, Shui-qin LAI, Wei-juan WU, Yu-mei WEI, Yi-feng SHEN, Hua-fang LI. Analysis of the global pipeline and development trend of antidepressants[J]. Chinese Journal of New Drugs, 2023 , 32 (3) : 217 -223 .
基金
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  • 上海市精神心理疾病临床医学研究中心项目(19MC-1911100)
  • 创新精神药物的协同研发和学术服务项目(TM202116PT)
  • 上海申康医院发展中心医企融合创新支撑技能培训专项项目(SHDC2022-CRS032)
2023年第32卷第3期
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文章信息
  • 首发时间：2026-03-05
  • 出版时间：2023-02-15
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出版历史
  • 录用日期：2022-06-18
基金
上海市精神心理疾病临床医学研究中心项目(19MC-1911100)
创新精神药物的协同研发和学术服务项目(TM202116PT)
上海申康医院发展中心医企融合创新支撑技能培训专项项目(SHDC2022-CRS032)
作者信息
    1上海交通大学医学院附属精神卫生中心，上海 200030
    2艾昆纬医药科技（上海）有限公司临床运营卓越中心， 上海 200032

通讯作者:

李华芳，女，博士生导师，教授，主要从事精神药理学研究。联系电话：(021)34773107，E-mail: 。
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Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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