Article(id=1236369022686646406, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236369013111050820, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1681660800000, acceptedDateStr=2023-04-17, onlineDate=1772702945633, onlineDateStr=2026-03-05, pubDate=1694707200000, pubDateStr=2023-09-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772702945633, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772702945633, creator=13701087609, updateTime=1772702945633, updator=13701087609, issue=Issue{id=1236369013111050820, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='17', pageStart='1697', pageEnd='1800', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772702943351, creator=13701087609, updateTime=1772703317941, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236370584322495028, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236369013111050820, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236370584326689333, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236369013111050820, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1795, endPage=1800, ext={EN=ArticleExt(id=1236369022938304681, articleId=1236369022686646406, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Economic evaluation of ferric carboxymaltose versus conventional therapy for perioperative anaemia in general surgery, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To evaluate the impact of budget on the total health care costs of using ferric carboxymaltose to correct iron deficiency anaemia compared with usual care in perioperative anaemia management in general surgery, and to provide a decision-making basis to promote the implementation of patient blood management (PBM) in China, particularly anaemia management focused on rapid and adequate iron supplementation in the perioperative period.
Methods: Based on Chinese epidemiological data, the differences in the reduction of allogeneic blood transfusion rate and length of stay in the perioperative period between the PBM group and the conventional treatment group were compared, and an analysis model of impact on budget was constructed combined with domestic cost data. Clinical outcomes were from data of foreign randomized clinical trials, and cost data were from public prices in the domestic market, including iron drug (oral iron, ferric carboxymaltose), injection, EPO use, blood transfusion, and hospitalization.
Results: Based on 3.758 million elective general surgery patients nationwide, the use of ferric carboxymaltose for anaemia management in the perioperative period as a complete substitute for routine care would have prevented 704,690 blood transfusions and saved a total of ￥139 million in treatment costs, with an average saving of ￥42 per patient. A sensitivity analysis showed total treatment cost savings of ￥1.086 billion, ￥2.033 billion, ￥2.981 billion and ￥3.928 billion assuming a 10%, 20%, 30% and 40% reduction in the price of ferric carboxymaltose, with average cost savings per patient being ￥289, ￥541, ￥793 and ￥1 045, respectively.
Conclusion: It is recommended that the patients with clinical perioperative iron deficiency anaemia undergo implementation of patient blood management and that ferric carboxymaltose be used for anaemia management.
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目的： 评估普外科围术期贫血管理中使用羧基麦芽糖铁纠正缺铁性贫血相比常规治疗对医疗总费用的影响，为推动国内实施患者血液管理（PBM），特别是围术期内以快速足量补铁为核心的贫血管理提供决策依据。
方法： 基于中国流行病学数据，对比PBM组与常规治疗组在围术期内减少异体输血率及住院天数的差异，并结合国内成本数据构建预算影响分析模型。临床结局基于国外随机临床试验数据，成本数据则基于国内市场公开价格。具体费用包括口服铁剂、羧基麦芽糖铁及注射费用、促红细胞生成素费用、输血费用和住院费用。
结果： 以全国375.8万普外科择期手术患者计算，围术期使用羧基麦芽糖铁进行贫血管理完全替代常规治疗，可以避免输血人数704 690人，节约总治疗费用1.39亿元，平均每位患者节约37元。单因素敏感度分析显示，随着羧基麦芽糖铁价格下降10%，20%，30%，40%，总治疗费用分别节约10.86，20.33，29.81和39.28亿元，平均每位患者费用分别节约289，541，793和1 045元。
结论： 建议临床围术期缺铁性贫血患者实施PBM，并推荐使用羧基麦芽糖铁进行贫血管理。
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, authorsList=孙文韬, 庄铃香, 杨艳丽, 马爱霞)}, authors=[Author(id=1236369023886217480, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369022686646406, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=sunwentao0322@163.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236369023991075089, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369022686646406, authorId=1236369023886217480, language=EN, stringName=Wen-tao SUN, firstName=Wen-tao, middleName=null, lastName=SUN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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1School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing 211198, China
2Vifor Fresenius Kabi (Beijing) Pharmaceutical Consulting Co., Ltd., Beijing 100028, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236369024066572566, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369022686646406, authorId=1236369023886217480, language=CN, stringName=孙文韬, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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1中国药科大学国际医药商学院，南京 211198
2维福费森尤斯卡比（北京）医药信息咨询有限公司，北京 100028, bio={"content":"
孙文韬，男，博士研究生，研究方向：药物经济学在药品政策中的应用。E-mail: sunwentao0322@163.com。
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孙文韬，男，博士研究生，研究方向：药物经济学在药品政策中的应用。E-mail: sunwentao0322@163.com。
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3瑞典于默奥大学流行病与公共卫生学院，于默奥 90130, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236369023630364911, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369022686646406, xref=3, ext=[AuthorCompanyExt(id=1236369023638753519, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369022686646406, companyId=1236369023630364911, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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