Article(id=1236369020216210171, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236369013111050820, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1665244800000, acceptedDateStr=2022-10-09, onlineDate=1772702945045, onlineDateStr=2026-03-05, pubDate=1694707200000, pubDateStr=2023-09-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772702945045, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772702945045, creator=13701087609, updateTime=1772702945045, updator=13701087609, issue=Issue{id=1236369013111050820, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='17', pageStart='1697', pageEnd='1800', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772702943351, creator=13701087609, updateTime=1772703317941, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236370584322495028, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236369013111050820, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236370584326689333, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236369013111050820, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1703, endPage=1706, ext={EN=ArticleExt(id=1236369020543365896, articleId=1236369020216210171, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Consideration of clinical orientation in the research of new traditional Chinese medicine, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Clinical orientation is the expected therapeutic effect of drugs on diseases, and accurate clinical orientation is the key to successful development of new drugs and clinical rational drug use after marketing. The rationality of clinical orientation for traditional Chinese medicine should be evaluated from the aspects of research drugs, targeting diseases, existing therapeutic drugs and review requirements. The methods and basis of clinical orientation include human experience, theory of traditional Chinese medicine, basic researches and clinical trials. By selecting reasonable clinical orientation and taking clinical value as the guidance, the curative effect of traditional Chinese medicine can be truly reflected, and the quality of research and development and success rate of new Chinese medicine will be improved.

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临床定位是药品在拟定目标适应证中预期的治疗作用,临床定位准确是新药研发成功和上市后临床合理用药的关键。在中药新药临床定位时,需要从研究药物、目标疾病、已有治疗措施和审评要求等维度评估合理性。临床定位的方法与依据包括人用经验、中医药理论、基础研究和临床试验等。以临床价值为导向,选定合理的临床定位,才能真正体现中药的疗效,提高中药新药的研发质量和成功率。

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程金莲,女,主任医师,研究方向:临床试验管理、医学伦理学、针灸学。联系电话:(010)52176813,E-mail:
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雷翔,男,硕士,主要从事循证中医药与中医药临床评价研究。E-mail:

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雷翔,男,硕士,主要从事循证中医药与中医药临床评价研究。E-mail:

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雷翔,男,硕士,主要从事循证中医药与中医药临床评价研究。E-mail:

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中药新药研发临床定位的相关思考
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雷翔 1 , 商洪才 2 , 高春升 1 , 欧阳绘天 1 , 崔天红 1 , 程金莲 3
中国新药杂志 | 新药述评与论坛 2023,32(17): 1703-1706
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中国新药杂志 | 新药述评与论坛 2023, 32(17): 1703-1706
中药新药研发临床定位的相关思考
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雷翔1 , 商洪才2, 高春升1, 欧阳绘天1, 崔天红1, 程金莲3
作者信息
  • 1北京岐黄科技有限公司研究院,北京 100055
  • 2北京中医药大学中医内科学教育部重点实验室,北京 100700
  • 3首都医科大学附属北京中医医院,北京 100010
  • 雷翔,男,硕士,主要从事循证中医药与中医药临床评价研究。E-mail:

通讯作者:

程金莲,女,主任医师,研究方向:临床试验管理、医学伦理学、针灸学。联系电话:(010)52176813,E-mail:
Consideration of clinical orientation in the research of new traditional Chinese medicine
Xiang LEI1 , Hong-cai SHANG2, Chun-sheng GAO1, Hui-tian OUYANG1, Tian-hong CUI1, Jin-lian CHENG3
Affiliations
  • 1Beijing Qi-Huang Technology Co., Ltd., Beijing 100055, China
  • 2Key Laboratory of Internal Medicine of Chinese Medicine, Ministry of Education, Beijing University of Chinese Medicine, Beijing 100700, China
  • 3Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China
出版时间: 2023-09-15
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临床定位是药品在拟定目标适应证中预期的治疗作用,临床定位准确是新药研发成功和上市后临床合理用药的关键。在中药新药临床定位时,需要从研究药物、目标疾病、已有治疗措施和审评要求等维度评估合理性。临床定位的方法与依据包括人用经验、中医药理论、基础研究和临床试验等。以临床价值为导向,选定合理的临床定位,才能真正体现中药的疗效,提高中药新药的研发质量和成功率。

临床定位  /  中药新药  /  临床研究  /  临床价值

Clinical orientation is the expected therapeutic effect of drugs on diseases, and accurate clinical orientation is the key to successful development of new drugs and clinical rational drug use after marketing. The rationality of clinical orientation for traditional Chinese medicine should be evaluated from the aspects of research drugs, targeting diseases, existing therapeutic drugs and review requirements. The methods and basis of clinical orientation include human experience, theory of traditional Chinese medicine, basic researches and clinical trials. By selecting reasonable clinical orientation and taking clinical value as the guidance, the curative effect of traditional Chinese medicine can be truly reflected, and the quality of research and development and success rate of new Chinese medicine will be improved.

clinical orientation  /  new traditional Chinese medicine  /  clinical research  /  clinical value
雷翔, 商洪才, 高春升, 欧阳绘天, 崔天红, 程金莲. 中药新药研发临床定位的相关思考. 中国新药杂志, 2023 , 32 (17) : 1703 -1706 .
Xiang LEI, Hong-cai SHANG, Chun-sheng GAO, Hui-tian OUYANG, Tian-hong CUI, Jin-lian CHENG. Consideration of clinical orientation in the research of new traditional Chinese medicine[J]. Chinese Journal of New Drugs, 2023 , 32 (17) : 1703 -1706 .
2023年第32卷第17期
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  • 首发时间:2026-03-05
  • 出版时间:2023-09-15
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  • 录用日期:2022-10-09
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作者信息
    1北京岐黄科技有限公司研究院,北京 100055
    2北京中医药大学中医内科学教育部重点实验室,北京 100700
    3首都医科大学附属北京中医医院,北京 100010

通讯作者:

程金莲,女,主任医师,研究方向:临床试验管理、医学伦理学、针灸学。联系电话:(010)52176813,E-mail:
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2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
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占总种数比例
Percentage of
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Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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