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The drug R&D of rare diseases in China is still in early stage. Collaborations have become a choice for many companies to enter that field. This article analyzes the collaboration deals involving Chinese companies from year 2011 to April 30th, 2022 on drugs with indication included in the first batch of rare disease list. It is found that as the country has put more emphasis on rare diseases, the number of transactions has increased significantly after the year of 2019. The deal model is mainly licensing deal, and transactions in rare disease indications with a big population is relatively concentrated. A group of biotechnology companies with rare diseases as their strategic focus have emerged. It is suggested to promote the legislation of rare diseases in China and more incentive policies concerning the research and development in rare diseases can be introduced in the future, so as to promote more Chinese companies to join in the research and development of innovative drugs in the rare diseases, and to further accelerate the development of local innovative drugs for rare diseases.

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我国企业在罕见病药物研发领域尚处于起步阶段，合作成为很多企业进入罕见病领域的选择。本文对2011年至2022年4月30日我国企业涉及第一批罕见病目录适应证药物的合作情况进行分析，发现随着国家对罕见病重视程度的提升，2019年之后合作数量有显著提升，合作方式以许可引进为主，人群较多的罕见病合作数量较为集中，涌现出了一批以罕见病为战略领域的生物科技企业。建议推动罕见病立法，可以出台更多罕见病研发相关的政策鼓励和激励企业加入罕见病领域的创新药研发中，推动本土创新罕见病药物的发展。

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俞颖慧，女，博士研究生，主要从事社会管理药学研究。E-mail: euge_013@163.com。

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俞颖慧，女，博士研究生，主要从事社会管理药学研究。E-mail: euge_013@163.com。

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