Article(id=1236369015262736745, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236369012058288373, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1683129600000, acceptedDateStr=2023-05-04, onlineDate=1772702943863, onlineDateStr=2026-03-05, pubDate=1693324800000, pubDateStr=2023-08-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772702943863, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772702943863, creator=13701087609, updateTime=1772702943863, updator=13701087609, issue=Issue{id=1236369012058288373, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='16', pageStart='1593', pageEnd='1696', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772702943100, creator=13701087609, updateTime=1772703272680, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236370394492490265, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236369012058288373, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236370394496684570, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236369012058288373, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1668, endPage=1676, ext={EN=ArticleExt(id=1236369015543755141, articleId=1236369015262736745, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Screening potential thymidylate kinase inhibitors from TCMSP database against monkeypox virus, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To screen potential small-molecule inhibitors of monkeypox virus thymidylate kinase from traditional Chinese medicine databases using virtual screening technology.
Methods: Based on the published monkeypox virus thymidylate kinase sequence, the three-dimensional structure of monkeypox virus thymidylate kinase was constructed using homology modeling technology, and multiple rounds of screening were performed using docking-based virtual screening technology, including high-throughput virtual screening, standard precision virtual screening, high precision virtual screening and Prime MMGBSA.
Results: Fifteen compounds with potential inhibitory activity against monkeypox virus thymidylate kinase were obtained by screening. The binding modes of compounds MOL002468, MOL009538, MOL000416 and MOL009237 with thymidylate kinase were analyzed for receptor-ligand interactions including hydrogen bonding, hydrophobic interactions, conjugation and salt bridges.
Conclusion: A virtual screening strategy for monkeypox virus thymidylate kinase was successfully constructed in order to discover new drugs that can be used to prevent and treat monkeypox virus, promoting further development and utilization of traditional Chinese medicine databases.
, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Yu-wei WANG, Wang-qi TIAN, Wei-tong ZHANG, Yi-fan WANG, Xiao-jie JIN, Yu-ping TANG, Tai-wei DONG), CN=ArticleExt(id=1236369015841550752, articleId=1236369015262736745, tenantId=1146029695717560320, journalId=1235980733773295621, language=CN, title=从TCMSP中药数据库中筛选猴痘病毒胸苷酸激酶抑制剂, columnId=1236330556003242277, journalTitle=中国新药杂志, columnName=实验研究, runingTitle=null, highlight=null, articleAbstract=
目的: 运用虚拟筛选技术从中药数据库中筛选猴痘病毒胸苷酸激酶潜在的中药小分子抑制剂。
方法: 基于已公布的猴痘病毒胸苷酸激酶序列,利用同源模建技术构建猴痘病毒胸苷酸激酶三维结构,运用基于对接的虚拟筛选技术进行多轮筛选,包括高通量虚拟筛选、标准精度虚拟筛选、高精度虚拟筛选、Prime MMGBSA结合自由能筛选等。
结果: 筛选出了15个对猴痘病毒胸苷酸激酶具有潜在抑制活性的化合物,并分析了化合物MOL002468,MOL009538,MOL000416,MOL009237与胸苷酸激酶的结合模式,包括氢键、疏水相互作用、共轭和盐桥等受体-配体相互作用。
结论: 成功构建猴痘病毒胸苷酸激酶的虚拟筛选策略,发掘可用于预防、治疗猴痘病毒的药物,促进传统中药数据库的进一步开发和利用。
, correspAuthors=null, authorNote=null, correspAuthorsNote=
, copyrightStatement=null, copyrightOwner=《中国新药杂志》有限公司, extLink=null, articleAbsUrl=null, sourceXml=Krxm8C5X3TGTpfmVyeh5FA==, magXml=syswEv4gBEIjk8OqdbM6ag==, pdfUrl=null, pdf=lVMb4NwxpFIRQrDbDUpJ2Q==, pdfFileSize=11636061, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=GcSzGnFdMutyjsjRkadOnA==, mapNumber=null, authorCompany=null, fund=null, authors=
, authorsList=王育伟, 田王琪, 张蔚桐, 汪一凡, 靳晓杰, 唐于平, 董泰玮)}, authors=[Author(id=1236369016269369801, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=wangyw09@gmail.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236369016386810323, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, authorId=1236369016269369801, language=EN, stringName=Yu-wei WANG, firstName=Yu-wei, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236369016500056542, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, authorId=1236369016269369801, language=CN, stringName=王育伟, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1陕西中医药大学药学院,西安 712046, bio={"content":"
王育伟,男,讲师,研究方向:计算机辅助药物设计与中药现代化研究。E-mail: wangyw09@gmail.com。
"}, bioImg=null, bioContent=
王育伟,男,讲师,研究方向:计算机辅助药物设计与中药现代化研究。E-mail: wangyw09@gmail.com。
, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236369016055460274, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, xref=1, ext=[AuthorCompanyExt(id=1236369016059654579, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, companyId=1236369016055460274, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China), AuthorCompanyExt(id=1236369016068043188, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, companyId=1236369016055460274, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1陕西中医药大学药学院,西安 712046)])]), Author(id=1236369016600719852, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236369016705577465, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, authorId=1236369016600719852, language=EN, stringName=Wang-qi TIAN, firstName=Wang-qi, middleName=null, lastName=TIAN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236369016827212291, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, authorId=1236369016600719852, language=CN, stringName=田王琪, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1陕西中医药大学药学院,西安 712046, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236369016055460274, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, xref=1, ext=[AuthorCompanyExt(id=1236369016059654579, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, companyId=1236369016055460274, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China), AuthorCompanyExt(id=1236369016068043188, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, companyId=1236369016055460274, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1陕西中医药大学药学院,西安 712046)])]), Author(id=1236369016940458515, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236369017120813593, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, authorId=1236369016940458515, language=EN, stringName=Wei-tong ZHANG, firstName=Wei-tong, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236369017238254115, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, authorId=1236369016940458515, language=CN, stringName=张蔚桐, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1陕西中医药大学药学院,西安 712046, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236369016055460274, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, xref=1, ext=[AuthorCompanyExt(id=1236369016059654579, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, companyId=1236369016055460274, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China), AuthorCompanyExt(id=1236369016068043188, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, companyId=1236369016055460274, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1陕西中医药大学药学院,西安 712046)])]), Author(id=1236369017435386417, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236369017527661116, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, authorId=1236369017435386417, language=EN, stringName=Yi-fan WANG, firstName=Yi-fan, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236369017615741509, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, authorId=1236369017435386417, language=CN, stringName=汪一凡, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1陕西中医药大学药学院,西安 712046, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236369016055460274, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, xref=1, ext=[AuthorCompanyExt(id=1236369016059654579, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, companyId=1236369016055460274, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China), AuthorCompanyExt(id=1236369016068043188, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, companyId=1236369016055460274, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1陕西中医药大学药学院,西安 712046)])]), Author(id=1236369017741570638, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236369017846428250, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, authorId=1236369017741570638, language=EN, stringName=Xiao-jie JIN, firstName=Xiao-jie, middleName=null, lastName=JIN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
2, address=
2College of Pharmacy, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236369017942897251, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, authorId=1236369017741570638, language=CN, stringName=靳晓杰, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
2, address=
2甘肃中医药大学药学院,兰州 730000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236369016151929277, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, xref=2, ext=[AuthorCompanyExt(id=1236369016168706496, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, companyId=1236369016151929277, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2College of Pharmacy, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China), AuthorCompanyExt(id=1236369016181289410, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, companyId=1236369016151929277, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2甘肃中医药大学药学院,兰州 730000)])]), Author(id=1236369018039366258, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=yupingtang@sntcm.edu.cn, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236369018190361214, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, authorId=1236369018039366258, language=EN, stringName=Yu-ping TANG, firstName=Yu-ping, middleName=null, lastName=TANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236369018274247300, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, authorId=1236369018039366258, language=CN, stringName=唐于平, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1陕西中医药大学药学院,西安 712046, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236369016055460274, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, xref=1, ext=[AuthorCompanyExt(id=1236369016059654579, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, companyId=1236369016055460274, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China), AuthorCompanyExt(id=1236369016068043188, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, companyId=1236369016055460274, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1陕西中医药大学药学院,西安 712046)])]), Author(id=1236369018374910606, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=1484904430@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236369018462991000, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, authorId=1236369018374910606, language=EN, stringName=Tai-wei DONG, firstName=Tai-wei, middleName=null, lastName=DONG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236369018567848609, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, authorId=1236369018374910606, language=CN, stringName=董泰玮, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, address=
1陕西中医药大学药学院,西安 712046, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1236369016055460274, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, xref=1, ext=[AuthorCompanyExt(id=1236369016059654579, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, companyId=1236369016055460274, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China), AuthorCompanyExt(id=1236369016068043188, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, companyId=1236369016055460274, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1陕西中医药大学药学院,西安 712046)])])], keywords=[Keyword(id=1236369018672706216, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, language=EN, orderNo=1, keyword=monkeypox), Keyword(id=1236369018798535346, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, language=EN, orderNo=2, keyword=thymidylate kinase), Keyword(id=1236369018886615735, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, language=EN, orderNo=3, keyword=molecular docking), Keyword(id=1236369018970501821, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, language=EN, orderNo=4, keyword=binding free energy), Keyword(id=1236369019096330950, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, language=EN, orderNo=5, keyword=virtual screening), Keyword(id=1236369019192799946, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, language=CN, orderNo=1, keyword=猴痘), Keyword(id=1236369019272491726, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, language=CN, orderNo=2, keyword=胸苷酸激酶), Keyword(id=1236369019364766415, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, language=CN, orderNo=3, keyword=分子对接), Keyword(id=1236369019511567062, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, language=CN, orderNo=4, keyword=结合自由能), Keyword(id=1236369019591258841, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, language=CN, orderNo=5, keyword=虚拟筛选)], refs=null, funds=[Fund(id=1236369019729670879, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, awardId=82003653, language=CN, fundingSource=国家自然科学基金项目(82003653), fundOrder=null, country=null), Fund(id=1236369019838722793, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, awardId=2021JQ-734, language=CN, fundingSource=陕西省自然科学基金项目(2021JQ-734), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1236369016055460274, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, xref=1, ext=[AuthorCompanyExt(id=1236369016059654579, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, companyId=1236369016055460274, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China), AuthorCompanyExt(id=1236369016068043188, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, companyId=1236369016055460274, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1陕西中医药大学药学院,西安 712046)]), AuthorCompany(id=1236369016151929277, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, xref=2, ext=[AuthorCompanyExt(id=1236369016168706496, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, companyId=1236369016151929277, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2College of Pharmacy, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China), AuthorCompanyExt(id=1236369016181289410, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236369015262736745, companyId=1236369016151929277, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2甘肃中医药大学药学院,兰州 730000)])], figs=null, attaches=null, journal=Journal(id=1235980159023624194, delFlag=0, nameCn=中国新药杂志, nameEn=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, issn=1003-3734, eissn=null, cn=11-2850/R, coden=ZXZHA6, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of New Drugs, journalRemark=null, publicationField=null, createdTime=1772610233314, updatedTime=1772610649152, createdBy=18614031015, updatedBy=13701087609, firstLetterCn=C, firstLetterEn=C, subjectCode=Life Sciences, subjectName=null, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=ohPEEN//Vz1tDT3ZBNTp4Q==, picEn=f9WK9bvTM4guTmS/iGhOMg==, jcr=null, cjcr=null, exts=[JournalExt(id=1235981903275290962, language=CN, name=中国新药杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1772610649174, updatedTime=1772610649174, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1235981903338205523, language=EN, name=Chinese Journal of New Drugs, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1772610649189, updatedTime=1772610649189, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=http://draft.newdrug.cn/journalx_zgxy/authorLogOn.action, submissionEditorUrl=http://draft.newdrug.cn/journalx_zgxy/editorLogOn.action, submissionReviewUrl=http://draft.newdrug.cn/journalx_zgxy/expertLogOn.action, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1235980733773295621, websiteList=[Website(id=1235982099191222761, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/CN, language=CN, createTime=1772610695884, createBy=18614031015, updateTime=1772610860397, updateBy=18614031015, name=中国新药杂志-中文, tplId=1146099689490845704, title=中国新药杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983918629966444, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=articleTextType, value=kx, createTime=1772611129672, updateTime=1772611129672, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918604800617, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=banner, value=null, createTime=1772611129666, updateTime=1772611129666, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918655132271, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=grayFlag, value=0, createTime=1772611129678, updateTime=1772611129678, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918596412008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611129664, updateTime=1772611129664, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918667715185, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=minRunFlag, value=0, createTime=1772611129681, updateTime=1772611129681, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918617383531, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/file/pic, createTime=1772611129669, updateTime=1772611129669, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918659326576, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=silenceFlag, value=0, createTime=1772611129679, updateTime=1772611129679, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918613189226, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1772611129668, updateTime=1772611129668, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918634160749, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeColor, value=null, createTime=1772611129673, updateTime=1772611129673, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983918646743662, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099191222761, code=themeStyle, value=null, createTime=1772611129676, updateTime=1772611129676, creator=18614031015, updator=18614031015)]), Website(id=1235982099270914542, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1235980733773295621, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zgxyzz/EN, language=EN, createTime=1772610695903, createBy=18614031015, updateTime=1772610875891, updateBy=18614031015, name=中国新药杂志-英文, tplId=1146101810881728533, title=Chinese Journal of New Drugs, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1235983955829248630, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=articleTextType, value=kx, createTime=1772611138541, updateTime=1772611138541, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955804082803, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=banner, value=null, createTime=1772611138535, updateTime=1772611138535, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955854414457, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=grayFlag, value=0, createTime=1772611138547, updateTime=1772611138547, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955795694194, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=logo, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic?fileId=W567vm71kFC7UhK9TSU6xw==, createTime=1772611138533, updateTime=1772611138533, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955866997371, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=minRunFlag, value=0, createTime=1772611138550, updateTime=1772611138550, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955820860021, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/file/pic, createTime=1772611138539, updateTime=1772611138539, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955862803066, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=silenceFlag, value=0, createTime=1772611138549, updateTime=1772611138549, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955812471412, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1772611138537, updateTime=1772611138537, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955837637239, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeColor, value=null, createTime=1772611138543, updateTime=1772611138543, creator=18614031015, updator=18614031015), WebsiteProps(id=1235983955846025848, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1235982099270914542, code=themeStyle, value=null, createTime=1772611138545, updateTime=1772611138545, creator=18614031015, updator=18614031015)])], journalTitle=中国新药杂志, weixinUrl=null, journalUrl=http://www.newdrug.cn/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of New Drugs, journalPhotoCn=ohPEEN//Vz1tDT3ZBNTp4Q==, journalPhotoEn=f9WK9bvTM4guTmS/iGhOMg==, journalFirstLetter=C, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false), detailUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/Y2023/V32/I16/1668, detailUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/Y2023/V32/I16/1668, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zgxyzz/CN/PDF/Y2023/V32/I16/1668, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zgxyzz/EN/PDF/Y2023/V32/I16/1668, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, reference=null)