Article(id=1236369012221858358, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236369011668210230, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1666540800000, acceptedDateStr=2022-10-24, onlineDate=1772702943139, onlineDateStr=2026-03-05, pubDate=1692028800000, pubDateStr=2023-08-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772702943139, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772702943139, creator=13701087609, updateTime=1772702943139, updator=13701087609, issue=Issue{id=1236369011668210230, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='15', pageStart='1489', pageEnd='1592', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772702943007, creator=13701087609, updateTime=1772703232203, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236370224711258643, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236369011668210230, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236370224711258644, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236369011668210230, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1531, endPage=1537, ext={EN=ArticleExt(id=1236369012431573560, articleId=1236369012221858358, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Tumor diagnosis and treatment strategies based on targeting folate receptor, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Folate receptors (FRs) are overexpressed in a variety of human cancers, such as ovarian, lung, breast and brain cancers. Folic acid (FA) is a high-affinity ligand of FRs that retains the receptor-binding properties after binding to other molecules. FRs targeting technology has been successfully applied to the diagnosis and treatment of FRs-positive tumors, and has significantly enhanced the specificity and selectivity to cancer cells. Therefore, FRs targeting strategies are expected to improve the safety and efficacy of clinically relevant anti-cancer drugs. In this review, we mainly summarizes tumor diagnosis and treatment strategies based on folate receptors targeting, with special attention to the latest progress in this field and possible future development.

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叶酸受体（folate receptors, FRs）在人类多种癌症中过表达，如卵巢癌、肺癌、乳腺癌、脑癌等。而叶酸（folic acid, FA）是FRs的高亲和力配体，当与其他分子结合时，仍保留其受体结合特性。基于FRs的靶向技术已成功应用于叶酸受体阳性肿瘤的诊断和治疗中，且显著增强了对癌细胞的特异性和选择性。因此，基于FRs的靶向策略有望提高临床上相关抗癌药物的安全性和有效性。本文主要对基于FRs靶向的肿瘤诊断及治疗策略进行综述，特别关注这一领域的最新进展以及未来可能的发展方向。

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何文丽，女，硕士研究生，研究方向：新型纳米药物递送系统。E-mail: 1439344761@qq.com。

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何文丽，女，硕士研究生，研究方向：新型纳米药物递送系统。E-mail: 1439344761@qq.com。

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