Article(id=1236360794313642544, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236360790672986545, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1703260800000, acceptedDateStr=2023-12-23, onlineDate=1772700983837, onlineDateStr=2026-03-05, pubDate=1703865600000, pubDateStr=2023-12-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772700983837, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772700983837, creator=13701087609, updateTime=1772700983837, updator=13701087609, issue=Issue{id=1236360790672986545, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='24', pageStart='2441', pageEnd='2543', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772700982968, creator=13701087609, updateTime=1772701059772, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236361112883622634, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236360790672986545, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236361112883622635, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236360790672986545, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=2531, endPage=2534, ext={EN=ArticleExt(id=1236360794552717885, articleId=1236360794313642544, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=The latest research progress of daridorexant, a dual orexin receptor antagonist for insomnia, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

There are many kinds of drugs for insomnia, but the current hypnotics on the market cannot fully meet the clinical needs. As a new treatment for insomnia disorder, dural orexin receptor antagonist (DORAs) has a different mechanism of action from the traditional hypnotics, it can avoid a series of common side effects of traditional hypnotics and has a good safety profile. A newly developed dual orexin receptor antagonist, daridorexant, has been studied in a number of clinical studies in global, and data shows that it improves both the sleeping disorder at night and daily functions, with good safety feature. This review comprehensively summarizes the efficacy, safety, and clinical data of the dual orexin antibody antagonist daridorexant in various clinical trials.

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治疗失眠障碍的药物种类繁多，然而当前市场上的失眠药物并不能完全满足临床需求。作为新型治疗失眠障碍的药物，双重食欲素受体拮抗剂（DORAs）与传统促眠药物有着不同的作用机制，它可以通过拮抗食欲素受体兴奋传导通路，选择性地影响大脑的睡眠/觉醒机制，能够避免常见传统促眠药物的一系列不良反应，并可有效改善睡眠障碍，在老年患者及青少年神经发育障碍患者中的失眠治疗效果均可观。最新研发的双重食欲素受体拮抗剂达利雷生（daridorexant）在全球已经开展了一系列临床研究，数据显示其不仅可以改善失眠障碍患者的夜间失眠症状和日间功能，且安全性和耐受性良好。本综述将对双重食欲素受体拮抗剂daridorexant的疗效、安全性以及各个研究阶段的临床数据进行总结。

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李馨如，女，硕士研究生，主要从事睡眠与癫痫研究。E-mail: lxr9871@163.com。

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李馨如，女，硕士研究生，主要从事睡眠与癫痫研究。E-mail: lxr9871@163.com。

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