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Immunotherapy combined with chemotherapy has been established as the standard first-line treatment in advanced esophageal cancer (EC). Myelosuppression is the most common side effects of chemotherapy, and severe myelosuppression often leads to prolonged cycles of chemotherapy and reduced doses of chemotherapy, thereby reducing the intensity and potential anti-tumor efficacy of chemotherapy. At present, granulocyte-stimulating factor (G-CSF) is widely used to stimulate the differentiation of bone marrow hematopoietic progenitor cells to treat chemotherapy-induced myelosuppression (CIM). Trilaciclib is a short-acting and reversible CDK4/6 inhibitor, which can provide systemic protection of bone marrow hematopoiesis, and was approved by NMPA in July 2022 for the prophylactic treatment of myelosuppression in extensive-stage small cell lung cancer (ES-SCLC). However, trilaciclib has not been widely used in clinical practice. Therefore, this paper reports a case of one patient with advanced EC who was treated by trilaciclib to prevent CIM in our department, aiming to provide further reference and basis for further investigation.

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免疫联合化疗已成为晚期食管癌一线治疗标准方案。骨髓抑制（CIM）是肿瘤化疗最常见的毒副作用，严重的骨髓抑制常导致化疗周期的延长和化疗剂量的减少，进而降低化疗强度和抗肿瘤疗效。目前，临床上使用粒细胞集落刺激因子（G-CSF）刺激骨髓造血祖细胞分化治疗化疗引起的骨髓抑制。曲拉西利是一种短效、可逆的细胞周期蛋白依赖性激酶4/6（CDK4/6）抑制剂，可从源头保护骨髓造血功能。曲拉西利已于2022年7月获批用于广泛期小细胞肺癌骨髓抑制的预防治疗。然而，曲拉西利尚未在临床上广泛应用于预防化疗引起的骨髓抑制。本文报道1例经治的晚期食管癌患者应用曲拉西利预防化疗引起的骨髓抑制的病例，以供同行参考。

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严京泽，男，硕士研究生，主要从事肿瘤相关治疗及研究。E-mail: yjz2022121090@163.com。

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严京泽，男，硕士研究生，主要从事肿瘤相关治疗及研究。E-mail: yjz2022121090@163.com。

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