Article(id=1236346592958140750, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236346588398932061, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1660665600000, acceptedDateStr=2022-08-17, onlineDate=1772697597970, onlineDateStr=2026-03-05, pubDate=1685376000000, pubDateStr=2023-05-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772697597970, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772697597970, creator=13701087609, updateTime=1772697597970, updator=13701087609, issue=Issue{id=1236346588398932061, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='10', pageStart='969', pageEnd='1072', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772697596882, creator=13701087609, updateTime=1772697715363, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236347085411373506, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236346588398932061, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236347085411373507, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236346588398932061, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1028, endPage=1036, ext={EN=ArticleExt(id=1236346593176244573, articleId=1236346592958140750, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Progress in research on the anti-inflammatory effect of curcumin on chronic inflammatory diseases, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Chronic inflammation is considered as a potential pathological state, which is the long-term presence of low concentrations of inflammatory factors in the body and continuous infection of the body, manifested by aggregation and infiltration of monocytes, lymphocytes and other cells, tissue proliferation, lesions, etc. Research shows that chronic inflammation can mediate cancer, diabetes, cardiovascular, nervous system, inflammatory bowel disease, lung disease and other diseases. Curcumin is an active component of polyphenols extracted from turmeric, a traditional Chinese medicine. It has significant anti-inflammatory activity, and its efficacy in controlling or treating a variety of chronic inflammatory diseases has been widely reported. On the other hand, inflammation-related signaling pathways, such as JAKs/STATs, PI3K/AKT/mTOR, Wnt/β-catenin, NF-κB, MAPK/ERK, etc., play key roles in the pathogenesis of various chronic inflammatory diseases. Signaling molecules in the pathway are considered to be important targets of new therapeutic approaches, and curcumin can participate in related inflammation-related signaling pathways to produce anti-inflammatory effects. In this paper, the pharmacological studies of curcumin in chronic inflammatory diseases in the past five years and the regulatory role of curcumin in the inflammatory signaling pathway were reviewed, to provide a reference for the research and development of curcumin in the prevention and treatment of chronic inflammatory diseases.

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慢性炎症被认为是一种潜在的病理状态,是体内长期存在低浓度致炎因子刺激且机体呈现持续感染状态,表现为单核细胞、淋巴细胞等聚集浸润,组织发生增生、病变等。研究表明慢性炎症可介导癌症、糖尿病、心血管疾病、神经系统疾病、炎症性肠病、肺部疾病等多种疾病。姜黄素是从中药姜黄中提取的多酚类活性成分,具有显著的抗炎活性,其在控制或治疗多种慢性炎症性疾病方面的疗效已被广泛报道。另一方面,炎症相关信号通路如Janus激酶(JAKs)/信号传导及转录激活蛋白(STATs)、磷脂酰肌醇3-激酶(PI3K)/丝氨酸/苏氨酸蛋白激酶(Akt)/雷帕霉素靶蛋白(mTOR)、Wnt/β-catenin、核因子-κB(NF-κB)、丝裂原活化蛋白激酶(MAPK)/细胞外调节蛋白激酶(ERK)等,在多种慢性炎症性疾病的发病机制中发挥关键作用,这些通路中的信号分子被认为是新治疗手段的重要靶点,姜黄素可参与相关炎症信号通路产生抗炎作用。本文对近5年来姜黄素在慢性炎症性疾病中的药理研究以及姜黄素在炎症信号通路的调控作用进行综述,以期为姜黄素在慢性炎症性疾病的预防及治疗中的药物研发提供可借鉴的思路。

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梁新丽,女,副教授,主要从事药物新剂型与新技术研究。联系电话:(0791)87118658,E-mail:
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汪新娌,女,硕士研究生,研究方向为中药新剂型与新技术。E-mail:

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姜黄素对慢性炎症性疾病抗炎作用研究进展
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汪新娌 1, 2 , 董伟 1 , 徐希强 1 , 李秋香 1 , 周爱鲜 1 , 梁新丽 1
中国新药杂志 | 综述 2023,32(10): 1028-1036
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中国新药杂志 | 综述 2023, 32(10): 1028-1036
姜黄素对慢性炎症性疾病抗炎作用研究进展
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汪新娌1, 2 , 董伟1, 徐希强1, 李秋香1, 周爱鲜1, 梁新丽1
作者信息
  • 1江西中医药大学现代中药制剂教育部重点实验室,南昌 330004
  • 2江西省医疗器械检测中心,南昌 330029
  • 汪新娌,女,硕士研究生,研究方向为中药新剂型与新技术。E-mail:

通讯作者:

梁新丽,女,副教授,主要从事药物新剂型与新技术研究。联系电话:(0791)87118658,E-mail:
Progress in research on the anti-inflammatory effect of curcumin on chronic inflammatory diseases
Xin-li WANG1, 2 , Wei DONG1, Xi-qiang XU1, Qiu-xiang LI1, Ai-xian ZHOU1, Xin-li LIANG1
Affiliations
  • 1Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China
  • 2Jiangxi Medical Device Testing Center, Nanchang 330029, China
出版时间: 2023-05-30
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慢性炎症被认为是一种潜在的病理状态,是体内长期存在低浓度致炎因子刺激且机体呈现持续感染状态,表现为单核细胞、淋巴细胞等聚集浸润,组织发生增生、病变等。研究表明慢性炎症可介导癌症、糖尿病、心血管疾病、神经系统疾病、炎症性肠病、肺部疾病等多种疾病。姜黄素是从中药姜黄中提取的多酚类活性成分,具有显著的抗炎活性,其在控制或治疗多种慢性炎症性疾病方面的疗效已被广泛报道。另一方面,炎症相关信号通路如Janus激酶(JAKs)/信号传导及转录激活蛋白(STATs)、磷脂酰肌醇3-激酶(PI3K)/丝氨酸/苏氨酸蛋白激酶(Akt)/雷帕霉素靶蛋白(mTOR)、Wnt/β-catenin、核因子-κB(NF-κB)、丝裂原活化蛋白激酶(MAPK)/细胞外调节蛋白激酶(ERK)等,在多种慢性炎症性疾病的发病机制中发挥关键作用,这些通路中的信号分子被认为是新治疗手段的重要靶点,姜黄素可参与相关炎症信号通路产生抗炎作用。本文对近5年来姜黄素在慢性炎症性疾病中的药理研究以及姜黄素在炎症信号通路的调控作用进行综述,以期为姜黄素在慢性炎症性疾病的预防及治疗中的药物研发提供可借鉴的思路。

姜黄素  /  慢性炎症  /  慢性炎症性疾病

Chronic inflammation is considered as a potential pathological state, which is the long-term presence of low concentrations of inflammatory factors in the body and continuous infection of the body, manifested by aggregation and infiltration of monocytes, lymphocytes and other cells, tissue proliferation, lesions, etc. Research shows that chronic inflammation can mediate cancer, diabetes, cardiovascular, nervous system, inflammatory bowel disease, lung disease and other diseases. Curcumin is an active component of polyphenols extracted from turmeric, a traditional Chinese medicine. It has significant anti-inflammatory activity, and its efficacy in controlling or treating a variety of chronic inflammatory diseases has been widely reported. On the other hand, inflammation-related signaling pathways, such as JAKs/STATs, PI3K/AKT/mTOR, Wnt/β-catenin, NF-κB, MAPK/ERK, etc., play key roles in the pathogenesis of various chronic inflammatory diseases. Signaling molecules in the pathway are considered to be important targets of new therapeutic approaches, and curcumin can participate in related inflammation-related signaling pathways to produce anti-inflammatory effects. In this paper, the pharmacological studies of curcumin in chronic inflammatory diseases in the past five years and the regulatory role of curcumin in the inflammatory signaling pathway were reviewed, to provide a reference for the research and development of curcumin in the prevention and treatment of chronic inflammatory diseases.

curcumin  /  chronic inflammation  /  chronic inflammatory disease
汪新娌, 董伟, 徐希强, 李秋香, 周爱鲜, 梁新丽. 姜黄素对慢性炎症性疾病抗炎作用研究进展. 中国新药杂志, 2023 , 32 (10) : 1028 -1036 .
Xin-li WANG, Wei DONG, Xi-qiang XU, Qiu-xiang LI, Ai-xian ZHOU, Xin-li LIANG. Progress in research on the anti-inflammatory effect of curcumin on chronic inflammatory diseases[J]. Chinese Journal of New Drugs, 2023 , 32 (10) : 1028 -1036 .
  • 国家自然科学基金项目(82060733)
  • 江西省科技厅2019年度重大科技研发专项资助项目(20194ABC28009)
  • 江西中医药大学校级研究生创新专项资金项目(JZYC20S04)
  • 江西中医药大学校级大学生创新创业训练计划项目(202110412199)
2023年第32卷第10期
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  • 首发时间:2026-03-05
  • 出版时间:2023-05-30
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  • 录用日期:2022-08-17
基金
国家自然科学基金项目(82060733)
江西省科技厅2019年度重大科技研发专项资助项目(20194ABC28009)
江西中医药大学校级研究生创新专项资金项目(JZYC20S04)
江西中医药大学校级大学生创新创业训练计划项目(202110412199)
作者信息
    1江西中医药大学现代中药制剂教育部重点实验室,南昌 330004
    2江西省医疗器械检测中心,南昌 330029

通讯作者:

梁新丽,女,副教授,主要从事药物新剂型与新技术研究。联系电话:(0791)87118658,E-mail:
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2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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