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The COVID-19 pandemic highlights the necessity of stockpiling rapid-response vaccine technology. Represented by nucleic acid vaccine and viral vector vaccine, the vaccine platform technology only needs the virus gene sequence to start research and development, and can rapidly expand production in a short period of time. It shows huge potential capacity of preventing and controlling emerging infectious diseases that spread fast, and affect a wide range of people who generally lack immunity. However, due to the rapid development of this field, few domestic literatures have described relevant concepts, definitions, and classifications. This review combed the related literatures and documents, summarized the definition, development and application of vaccine platform technology and explained its important role for emergent research and development of emerging infectious diseases. It provided scientific basis and suggestions for China to build up strategic stockpiles of related vaccine platform technologies and improve the capability of preparedness and response to emerging infectious diseases.
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新型冠状病毒肺炎(COVID-19)疫情凸显出储备快速研发疫苗技术的必要性,以核酸疫苗和病毒载体疫苗为代表的疫苗平台技术只需要病毒基因序列即可启动研发,并在短期内快速扩产,适用于传播速度快、波及范围广且人群普遍缺乏免疫力的新发传染病。但由于该研究领域尚处于快速发展阶段,鲜有国内文献对相关概念、定义和分类进行描述。本研究系统梳理了相关文献和资料文件,总结疫苗平台技术的定义、发展现状及应用前景,阐述开发疫苗平台技术对于新发传染病应急研发的重要作用,为我国建立相关疫苗平台技术战略储备、提高新发传染病预防和应对能力提供科学依据和对策建议。
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, authorsList=马继炎, 刘佐坤, 黄旸木)}, authors=[Author(id=1236346591125229767, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236346590382837907, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=jiyma@bjmu.edu.cn, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1236346591217504462, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236346590382837907, authorId=1236346591125229767, language=EN, stringName=Ji-yan MA, firstName=Ji-yan, middleName=null, lastName=MA, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Global Health, School of Public Health, Peking University, Beijing 100191, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236346591339139287, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236346590382837907, authorId=1236346591125229767, language=CN, stringName=马继炎, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=北京大学公共卫生学院全球卫生学系,北京 100191, bio={"content":"
马继炎,女,博士研究生,主要从事全球卫生、新发传染病研究。E-mail: jiyma@bjmu.edu.cn。
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马继炎,女,博士研究生,主要从事全球卫生、新发传染病研究。E-mail: jiyma@bjmu.edu.cn。
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