Article(id=1236346590382837907, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236346588398932061, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1663603200000, acceptedDateStr=2022-09-20, onlineDate=1772697597355, onlineDateStr=2026-03-05, pubDate=1685376000000, pubDateStr=2023-05-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772697597355, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772697597355, creator=13701087609, updateTime=1772697597355, updator=13701087609, issue=Issue{id=1236346588398932061, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='10', pageStart='969', pageEnd='1072', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772697596882, creator=13701087609, updateTime=1772697715363, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236347085411373506, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236346588398932061, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236347085411373507, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236346588398932061, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1007, endPage=1012, ext={EN=ArticleExt(id=1236346590605136029, articleId=1236346590382837907, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=International development of vaccine platform technology and its implications for China's strategic stockpile of emerging infectious diseases, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

The COVID-19 pandemic highlights the necessity of stockpiling rapid-response vaccine technology. Represented by nucleic acid vaccine and viral vector vaccine, the vaccine platform technology only needs the virus gene sequence to start research and development, and can rapidly expand production in a short period of time. It shows huge potential capacity of preventing and controlling emerging infectious diseases that spread fast, and affect a wide range of people who generally lack immunity. However, due to the rapid development of this field, few domestic literatures have described relevant concepts, definitions, and classifications. This review combed the related literatures and documents, summarized the definition, development and application of vaccine platform technology and explained its important role for emergent research and development of emerging infectious diseases. It provided scientific basis and suggestions for China to build up strategic stockpiles of related vaccine platform technologies and improve the capability of preparedness and response to emerging infectious diseases.

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新型冠状病毒肺炎(COVID-19)疫情凸显出储备快速研发疫苗技术的必要性,以核酸疫苗和病毒载体疫苗为代表的疫苗平台技术只需要病毒基因序列即可启动研发,并在短期内快速扩产,适用于传播速度快、波及范围广且人群普遍缺乏免疫力的新发传染病。但由于该研究领域尚处于快速发展阶段,鲜有国内文献对相关概念、定义和分类进行描述。本研究系统梳理了相关文献和资料文件,总结疫苗平台技术的定义、发展现状及应用前景,阐述开发疫苗平台技术对于新发传染病应急研发的重要作用,为我国建立相关疫苗平台技术战略储备、提高新发传染病预防和应对能力提供科学依据和对策建议。

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黄旸木,女,博士,研究员,主要从事卫生发展合作、全球公共卫生产品创新与可及研究。E-mail:
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马继炎,女,博士研究生,主要从事全球卫生、新发传染病研究。E-mail:

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马继炎,女,博士研究生,主要从事全球卫生、新发传染病研究。E-mail:

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马继炎,女,博士研究生,主要从事全球卫生、新发传染病研究。E-mail:

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疫苗平台技术的国际发展及对我国新发传染病战略储备的启示
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马继炎 , 刘佐坤 , 黄旸木
中国新药杂志 | 生物医药前沿 2023,32(10): 1007-1012
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中国新药杂志 | 生物医药前沿 2023, 32(10): 1007-1012
疫苗平台技术的国际发展及对我国新发传染病战略储备的启示
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马继炎 , 刘佐坤, 黄旸木
作者信息
  • 北京大学公共卫生学院全球卫生学系,北京 100191
  • 马继炎,女,博士研究生,主要从事全球卫生、新发传染病研究。E-mail:

通讯作者:

黄旸木,女,博士,研究员,主要从事卫生发展合作、全球公共卫生产品创新与可及研究。E-mail:
International development of vaccine platform technology and its implications for China's strategic stockpile of emerging infectious diseases
Ji-yan MA , Zuo-kun LIU, Yang-mu HUANG
Affiliations
  • Department of Global Health, School of Public Health, Peking University, Beijing 100191, China
出版时间: 2023-05-30
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新型冠状病毒肺炎(COVID-19)疫情凸显出储备快速研发疫苗技术的必要性,以核酸疫苗和病毒载体疫苗为代表的疫苗平台技术只需要病毒基因序列即可启动研发,并在短期内快速扩产,适用于传播速度快、波及范围广且人群普遍缺乏免疫力的新发传染病。但由于该研究领域尚处于快速发展阶段,鲜有国内文献对相关概念、定义和分类进行描述。本研究系统梳理了相关文献和资料文件,总结疫苗平台技术的定义、发展现状及应用前景,阐述开发疫苗平台技术对于新发传染病应急研发的重要作用,为我国建立相关疫苗平台技术战略储备、提高新发传染病预防和应对能力提供科学依据和对策建议。

疫苗  /  平台技术  /  新发传染病  /  应急研发  /  战略储备

The COVID-19 pandemic highlights the necessity of stockpiling rapid-response vaccine technology. Represented by nucleic acid vaccine and viral vector vaccine, the vaccine platform technology only needs the virus gene sequence to start research and development, and can rapidly expand production in a short period of time. It shows huge potential capacity of preventing and controlling emerging infectious diseases that spread fast, and affect a wide range of people who generally lack immunity. However, due to the rapid development of this field, few domestic literatures have described relevant concepts, definitions, and classifications. This review combed the related literatures and documents, summarized the definition, development and application of vaccine platform technology and explained its important role for emergent research and development of emerging infectious diseases. It provided scientific basis and suggestions for China to build up strategic stockpiles of related vaccine platform technologies and improve the capability of preparedness and response to emerging infectious diseases.

vaccine  /  platform technology  /  emerging infectious diseases  /  emergent research and development  /  strategic stockpile
马继炎, 刘佐坤, 黄旸木. 疫苗平台技术的国际发展及对我国新发传染病战略储备的启示. 中国新药杂志, 2023 , 32 (10) : 1007 -1012 .
Ji-yan MA, Zuo-kun LIU, Yang-mu HUANG. International development of vaccine platform technology and its implications for China's strategic stockpile of emerging infectious diseases[J]. Chinese Journal of New Drugs, 2023 , 32 (10) : 1007 -1012 .
  • 国家自然科学基金项目(7207040929)
2023年第32卷第10期
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  • 首发时间:2026-03-05
  • 出版时间:2023-05-30
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  • 录用日期:2022-09-20
基金
国家自然科学基金项目(7207040929)
作者信息
    北京大学公共卫生学院全球卫生学系,北京 100191

通讯作者:

黄旸木,女,博士,研究员,主要从事卫生发展合作、全球公共卫生产品创新与可及研究。E-mail:
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2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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