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Cancer has always been a major disease that threatens human lives. Traditional treatment modalities cannot guarantee efficient killing of tumor cells and good prognosis after treatment, mainly because people do not have sufficient understanding of tumors and their microenvironment. In recent years, with the advancement of tumor research, the mechanism of tumorigenesis and the impact of tumors on human immune system have become hot topics of research. Various preclinical tumor models have been developed, including in vivo models represented by patient tumor-derived xenograft models (PDX) and in vitro models represented by organoid microarrays, which have different functions in preclinical tumor research and play important roles. As a convenient and effective tool, preclinical tumor models play an irreplaceable role in exploring tumor-immune system interactions, preclinical evaluation of anti-tumor drugs, and discovery of biomarkers for immunotherapy.

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癌症一直是威胁人类生命安全的重大疾病之一，传统的治疗方式无法保证药物针对肿瘤细胞的高效杀伤和治疗后的良好预后，主要原因是人们对肿瘤及其微环境的了解还不够充分。近年来随着人们对肿瘤研究的不断深入，肿瘤的发生机制和肿瘤对人体免疫系统的影响成为当下研究的热点，研究肿瘤细胞的相关机制需要既能够代表人体免疫系统，又能还原患者肿瘤微环境的临床前肿瘤模型。近年来随着各种临床前肿瘤模型的发展，包括以患者肿瘤组织来源的异种移植模型（PDX）为代表的体内模型和以类器官芯片为代表的体外模型，在肿瘤的临床前研究中充当不同的角色并且发挥了各自重要的作用。临床前肿瘤模型作为一种便捷有效的工具，在探索肿瘤与免疫系统相互作用、临床前抗肿瘤药物的评价、发现免疫治疗的生物标志物等方面发挥着不可替代的作用。

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许瀚林，男，硕士研究生，主要从事淋巴T细胞相关生物标志物的转化临床研究。E-mail: 2397066097@qq.com。

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许瀚林，男，硕士研究生，主要从事淋巴T细胞相关生物标志物的转化临床研究。E-mail: 2397066097@qq.com。

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