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The aim of the article was to clarify the factors affecting the investment in cooperation and innovation in different sub-sectors of China's pharmaceutical manufacturing industry and its mechanism of action, and provide a reference for improving the level of investment in this field. Based on the relevant indicator data of different sub-sectors of China's pharmaceutical manufacturing industry from 2009 to 2019, the factor analysis method is used to empirically analyze the impact of the summarized factors on the investment in cooperative innovation. It was found that internal investment in research and development funds, investment in scientific and technological activities, investment in new product development, profitability, effective invention patents, and government funding all have a positive impact on investment in cooperative innovation in different sub-sectors of China's pharmaceutical manufacturing industry. Their impact on biopharmaceutical manufacturing industry is greater than that on chemical manufacturing industry, followed by the Chinese patent medicine manufacturing industry. Whereas the degree of enterprise openness has a negative impact on the investment in cooperation and innovation in different sub-sectors of the Chinese pharmaceutical manufacturing industry.

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本文旨在明确我国医药制造业不同子行业合作创新资金投入的影响因素及其作用机制，为提升我国医药制造业不同子行业合作创新资金投入水平提供参考。基于2009—2019年我国医药制造业不同子行业相关指标数据，使用因子分析方法实证分析所归纳因素对其合作创新资金投入的影响。研发资金内部投入、科技活动人员投入、新产品开发投入、盈利水平、有效发明专利和政府资助对我国医药制造业不同子行业合作创新资金投入均为正向影响，这种促进作用体现为生物药品制造业>化学药品制造业>中成药制造业；而企业开放度对我国医药制造业不同子行业合作创新资金投入均为负向影响。

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范明杰，男，副研究员，主要从事新药研发工作。E-mail: mingjie.fan@outlook.com。

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范明杰，男，副研究员，主要从事新药研发工作。E-mail: mingjie.fan@outlook.com。

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