Article(id=1236346469976953763, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236346464578891843, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1673020800000, acceptedDateStr=2023-01-07, onlineDate=1772697568648, onlineDateStr=2026-03-05, pubDate=1684080000000, pubDateStr=2023-05-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772697568648, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772697568648, creator=13701087609, updateTime=1772697568648, updator=13701087609, issue=Issue{id=1236346464578891843, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='9', pageStart='865', pageEnd='968', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772697567361, creator=13701087609, updateTime=1772697682369, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236346947028701631, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236346464578891843, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236346947028701632, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236346464578891843, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=916, endPage=920, ext={EN=ArticleExt(id=1236346470207640502, articleId=1236346469976953763, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Inetetamab combining pyrotinib as second-line treatment of HER2-positive patients: A case report, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective: To explore the safety and efficacy of Inetetamab combined with Pyrotinib in the treatment of HER2-positive breast cancer.
Methods: A case of patient was reported with right breast invasive ductal carcinoma with multiple systemic metastases. The patients were found progressing after 3 cycles of docetaxel+Capecitabine+Trastuzumab regimen as the first line therapy for Trastuzumab primary resistance. Second-line therapy combined inetetamab with pyrotinib (inetetamab 8 mg·kg-1 for the first time, followed by 6 mg·kg-1, q3w+pyrotinib 400 mg·d-1, qd+vinorelbine 35 mg day 1, day 8 q3w) for 18 cycles.
Results: The patients achieved partial response (PR) at the first evaluation. During the 18 cycles of treatment, the efficacy was evaluated as continuous PR. The current progress free survival (PFS) was more than 16 months. No grade III or above adverse reactions occurred during the treatment, and the patients were well tolerated.
Conclusion: The combination of inetetamab with pyrotinib is effective and safe in the treatment of metastatic HER2-positive breast cancer.
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目的: 探索伊尼妥单抗联合吡咯替尼治疗HER2阳性乳腺癌患者的安全性及疗效。
方法: 报道1例右乳腺浸润性导管癌并全身多处转移患者,一线使用多西他赛+卡培他滨+曲妥珠单抗方案3周期后进展,为曲妥珠单抗原发耐药患者,二线使用含伊尼妥单抗联合吡咯替尼方案(伊尼妥单抗首次8 mg·kg-1,之后6 mg·kg-1,3周1次+吡咯替尼400 mg·d-1, qd+长春瑞滨35 mg,d 1,d 8,3周1次 ),应用此方案共18周期。
结果: 患者第1次评价疗效即达到部分缓解,在18周期治疗期间,评价疗效为持续部分缓解状态,目前无进展生存期已大于16个月。治疗过程中未出现Ⅲ级及以上不良反应,患者耐受良好。
结论: 伊尼妥单抗联合吡咯替尼的治疗模式对转移性HER2阳性乳腺癌有一定的临床疗效,安全性良好。
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李扬,女,主任医师,主要从事乳腺癌等恶性肿瘤的综合治疗。E-mail: young88818@168.com。
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李扬,女,主任医师,主要从事乳腺癌等恶性肿瘤的综合治疗。E-mail: young88818@168.com。
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