Article(id=1236346466969645192, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236346464578891843, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1652112000000, acceptedDateStr=2022-05-10, onlineDate=1772697567932, onlineDateStr=2026-03-05, pubDate=1684080000000, pubDateStr=2023-05-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772697567932, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772697567932, creator=13701087609, updateTime=1772697567932, updator=13701087609, issue=Issue{id=1236346464578891843, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='9', pageStart='865', pageEnd='968', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772697567361, creator=13701087609, updateTime=1772697682369, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236346947028701631, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236346464578891843, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236346947028701632, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236346464578891843, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=906, endPage=910, ext={EN=ArticleExt(id=1236346467384881310, articleId=1236346466969645192, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=Research progress of anti-tumor mechanism of anlotinib, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

In recent years, molecular targeted drugs involved in the pathogenesis and progression of cancer are being extensively investigated. Anlotinib, a novel multi-target tyrosine kinase inhibitor, is the first third-line treatment approved for patients with advanced non-small cell lung cancer in China, and has been approved for the treatment of soft tissue sarcoma, small cell lung cancer, medullary thyroid cancer and differentiated thyroid cancer. Numerous studies in China and abroad have found that this drug has three major functions, which are anti-tumor angiogenesis, inhibition of tumor growth and remodelling of the tumor microenvironment, and it can inhibit the development of solid tumours through various mechanisms. In this review, we summarize the role of anlotinib in various malignancies and research progress of related mechanism, to provide reference for its clinical application in oncology treatment.

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近年来，针对参与癌症发病机制和进展的分子靶向药物正在广泛研究中。安罗替尼作为一种新型多靶点酪氨酸激酶抑制剂，是我国首个获批用于晚期非小细胞肺癌患者的三线治疗药物，目前已陆续获批用于软组织肉瘤、小细胞肺癌、甲状腺髓样癌、分化型甲状腺癌的治疗。国内外大量研究发现该药物具有抗肿瘤血管新生、抑制肿瘤生长、重塑肿瘤微环境三大功能，可通过多种机制抑制实体肿瘤的发生发展。本文对安罗替尼在各种恶性肿瘤中的作用及相关机制研究进展进行梳理，为其在肿瘤治疗的临床应用提供参考。

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²Tianjin Medical University, Tianjin 300070, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1236346468785778959, tenantId=1146029695717560320, journalId=1235980733773295621, articleId=1236346466969645192, authorId=1236346468584452355, language=CN, stringName=纪雨柔, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=¹天津市中心妇产科医院妇瘤科，天津 300100
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纪雨柔，女，硕士研究生，主要从事靶向药物与卵巢癌基础研究。E-mail: jyr_smile@163.com。

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纪雨柔，女，硕士研究生，主要从事靶向药物与卵巢癌基础研究。E-mail: jyr_smile@163.com。

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