Article(id=1236346465279340612, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236346464578891843, articleNumber=null, orderNo=null, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=1676563200000, acceptedDateStr=2023-02-17, onlineDate=1772697567528, onlineDateStr=2026-03-05, pubDate=1684080000000, pubDateStr=2023-05-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1772697567528, onlineIssueDateStr=2026-03-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1772697567528, creator=13701087609, updateTime=1772697567528, updator=13701087609, issue=Issue{id=1236346464578891843, tenantId=1146029695717560320, journalId=1235980733773295621, year='2023', volume='32', issue='9', pageStart='865', pageEnd='968', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1772697567361, creator=13701087609, updateTime=1772697682369, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1236346947028701631, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236346464578891843, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1236346947028701632, tenantId=1146029695717560320, journalId=1235980733773295621, issueId=1236346464578891843, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=902, endPage=905, ext={EN=ArticleExt(id=1236346465489055815, articleId=1236346465279340612, tenantId=1146029695717560320, journalId=1235980733773295621, language=EN, title=The signal pathway involved in the treatment of vascular cognitive impairment in rats by butylphthalide, columnId=null, journalTitle=Chinese Journal of New Drugs, columnName=null, runingTitle=null, highlight=null, articleAbstract=

Vascular cognitive impairment (VCI) refers to a group of cognitive disorders caused by cerebrovascular disease or its related risk factors. The main clinical characteristics include cognitive dysfunction, with reduction of attention, memory and executive ability, and in severe cases, vascular dementia. DL-3-N-butylphthalein (NBP) is used to improve vascular cognitive impairment. It can increase the survival number of hippocampal neurons, promote synaptic formation, facilitate cerebrovascular regeneration, regulate cell apoptosis, thus exert a therapeutic effect of nerve function improvement. In recent years, more and more literatures was reported on the mechanism of NBP in the treatment of vascular cognitive impairment. This article will systematically elaborate the signal pathway and mechanism involved in the treatment of NBP that have been found so far, so as to provide reference and support for the further research on the prevention and treatment of vascular cognitive impairment.

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血管性认知障碍（VCI）是指由脑血管病变或其相关危险因素所致的一组认知障碍疾病，主要临床特征为认知功能障碍以及注意力、记忆力及执行力等的降低，严重者表现为血管性痴呆。DL-3-正丁基苯酞（NBP）是一种可用于改善血管性认知障碍的药物，能够增加海马神经元存活数量、促进神经突触形成、利于脑血管再生、调控细胞凋亡等，可起到改善神经功能的作用。近年，关于DL-3-正丁基苯酞治疗血管性认知障碍的作用机制的文献越来越多，以下将对目前已被研究发现的一些DL-3-正丁基苯酞发挥治疗作用时涉及的信号通路及其机制进行系统阐述，为进一步对防治血管性认知障碍的研究提供参考和支持。

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任安歌硕，女，硕士研究生，研究方向：血管性认知障碍。E-mail: r15232176072@163.com。

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任安歌硕，女，硕士研究生，研究方向：血管性认知障碍。E-mail: r15232176072@163.com。

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